Clinical trials
BOTOX clinical trials
Below are recruiting botox clinical trials, each written for real people, not researchers. We’re tracking 43 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07665528Recruiting
Botox vs Botox with surgery for chronic anal fissure
This trial compares two treatments for a long-lasting anal fissure: Botox injections alone versus Botox combined with a small surgery (fissurectomy and anoplasty). It aims to see which works better and may help patients who have not healed with standard care.
Islamabad, FederalAges 18–65 - NCT06075134Recruiting
EMG-guided vs. standard Botox for gummy smile treatment
This trial compares two ways of giving Botox for a gummy smile: one using a machine that measures muscle activity (EMG‑guided) and the usual method. The goal is to see which approach works better.
CairoAges 18–50 - NCT04731961Recruiting
Fewer Botox shots for urgency bladder leakage
This trial tests whether you can get fewer Botox injections to control urgency urinary incontinence (sudden, hard-to-hold urine leaks). It may help people reduce how often they need bladder injections while still improving symptoms.
Charlottesville, VirginiaAges 21 years+ - NCT06553950Recruiting
Splint vs botox for jaw and neck pain
This trial compares a custom jaw splint with botox injections to see which better reduces neck muscle tension in people with jaw joint problems. It's for patients who have a displaced jaw disc that still clicks or pops and also have neck muscle spasms.
CairoAges 18–40 - NCT06734598RecruitingPhase 4
Botox for Jaw Tightness After Head and Neck Radiation
This study tests whether Botox injections into the jaw muscles can help head and neck cancer survivors who have trouble opening their mouths (trismus) after radiation therapy. If you have tight or painful jaw muscles and limited mouth opening, this treatment may offer relief.
TaipeiAges 18 years+ - NCT06544993Recruiting
Microneedling with Botox vs Meso-Botox for acne scars
This study compares two treatments for sunken acne scars on the face: microneedling combined with Botox versus a 'meso-Botox' injection. Each side of your face gets one treatment, so doctors can see which works better for you.
SohagAges 18–50 - NCT06974617Recruiting
Nerve block vs. Botox for chronic migraine
This study compares two treatments for chronic migraine: a nerve block (sphenopalatine block) and Botox injections. It aims to see which one works better for reducing headache days.
CairoAges 18–65 - NCT05598723RecruitingPhase 3
Botox versus Xeomin for chronic migraine in adults
This Phase 3 study compares two headache injections—Botox and Xeomin—for people with chronic migraine. It may help find out which option works better to reduce frequent, long-lasting migraine days.
Jacksonville, North CarolinaAges 18–89 - NCT07220382RecruitingPhase 4
Botox injections before large hernia surgery
This trial tests if getting Botox shots in the belly muscles before hernia surgery makes the repair easier and more successful. It is for adults who need a planned, open surgery for a large ventral hernia.
Cleveland, OhioAges 18 years+ - NCT05968885RecruitingPhase 4
Compare Botox and combination medicines for overactive bladder
This study tests whether Botox injections work better than a combination of medicines (anti-muscarinics plus a beta-3 medicine) for people whose overactive bladder symptoms did not improve with one medicine alone. It may help by improving bladder control and reducing urgent, hard-to-hold urine leaks or frequent urination.
TaipeiAges 20–90 - NCT04695600RecruitingPhase 2/Phase 3
Botox for swallowing problems after brain injury
This trial tests if Botox injections in the throat can help people who have trouble swallowing due to a brain condition like stroke. It aims to improve safety and ease of eating and drinking.
New Delhi, National Capital Territory of DelhiAges 14 years+ - NCT06721520RecruitingPhase 2/Phase 3
Botox vs. Pyloromyotomy for stomach drainage after esophageal surgery
This trial compares two ways to help the stomach drain properly after surgery to remove part of the esophagus. One uses Botox injected into the stomach outlet, the other is a surgical cut of the muscle. The goal is to see which method works better at preventing stomach emptying problems.
Cleveland, OhioAges 18 years+ - NCT07666347Recruiting
Botox and Hyaluronic Acid Injections for Knee Osteoarthritis
This study tests if injecting Botox and hyaluronic acid into the knee joint can reduce pain and improve function in people with advanced knee osteoarthritis. It compares this combination to a standard treatment.
Tanta, El-GharbiaAges 50 years+ - NCT06793683Enrolling by invitationEarly Phase 1
Early Botox for bladder control after spinal cord injury
This trial tests if giving Botox injections early (within 20 weeks of injury) into the bladder muscle can help with bladder function and prevent problems. It may help people with recent, severe spinal cord injuries above the T6 level.
Seattle, WashingtonAges 18–65 - NCT03654066Enrolling by invitationPhase 4
Botox treatment with or without esophagus stretching for achalasia
This trial tests whether relaxing the esophagus with Botox (botulinum toxin), with or without an additional stretching procedure, can help people with achalasia. It is for adults who already have achalasia but cannot safely do the usual “definitive” procedures, and who are planning a routine upper endoscopy.
Nashville, TennesseeAges 18 years+ - NCT06783114RecruitingPhase 2/Phase 3
Testing a new Botox-like injection for arm stiffness after stroke
This study tests an investigational botulinum toxin injection (YY001) to reduce muscle stiffness in the arm after a stroke. It may help you move your arm more easily and improve daily tasks.
Hefei, AnhuiAges 18–75 - NCT05218785Recruiting
Botulinum toxin for calf tightness and long-term heel pain
This trial tests whether injections of botulinum toxin A can loosen a tight calf muscle and improve long-lasting plantar fasciitis (heel/foot pain). It’s for people whose symptoms have lasted at least a year and who haven’t improved enough with physical therapy.
Oslo, OsloAges 18–75 - NCT04444440RecruitingPhase 4
Antibiotic prevention after bladder Botox for overactive bladder
This trial studies whether taking an antibiotic around the time of bladder Botox can lower the risk of urinary infections. It’s for women with overactive bladder who tried standard medicines but didn’t get enough relief.
Edmonton, AlbertaAges 18 years+ - NCT07108920Recruiting
Balance and Botox for Stiff Knee Gait
This study tests whether botulinum toxin (Botox) injections into the rectus femoris thigh muscle can improve balance and walking in people with a stiff knee gait (a common problem after stroke, brain injury, or multiple sclerosis).
Héricourt, Nord Franche-ComtéAges 18 years+ - NCT06881147Enrolling by invitation
Physiotherapy and Botox for Neck Dystonia
This study tests whether combining physiotherapy with Botox injections can improve neck control in people with cervical dystonia. It also looks at how 'sensory tricks' (like touching your face) help the brain control symptoms, using brain scans to understand why.
Milan, ItaliaAges Any age - NCT07549113Recruiting
Preoperative prep methods for large abdominal wall hernias
This trial compares different ways to prepare your body before surgery to repair a large hernia (bulge in your abdominal wall). The goal is to find the best approach to help you heal well after surgery.
Krasnodar, Krasnodarskiy KrayAges 18 years+ - NCT06577285Recruiting
Botox for gummy smile with zinc and phytase supplements
This trial tests if taking zinc and phytase supplements can make Botox work better for treating a gummy smile. It may help people who show too much gum when they smile.
CairoAges 18–60 - NCT06543979RecruitingPhase 1/Phase 2
Anorectal manometry for children with chronic constipation
This study is for children aged 4–16 who have long-term constipation that doesn't get better with standard laxatives. It uses a test called anorectal manometry to measure how well the muscles in the bottom work, which can help guide treatment.
CairoAges 4–16 - NCT06903975RecruitingPhase 4
Botox for a more feminine neck appearance
This trial tests Botox injections into the neck muscles to create a more feminine neck contour. It may be an option if you're looking for a non-surgical way to soften or slim the look of your neck.
Newton, MassachusettsAges 18–65
Hear when a new BOTOX trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for botox?
- Yes. Clin2 currently lists 43 recruiting botox studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a botox trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a botox trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.