Breast Adenocarcinoma clinical trials

Test of chemotherapy plus your own stem cells for metastatic cancer

This Phase 1 trial tests a treatment approach using standard chemotherapy along with stem cells taken from you to treat metastatic pancreatic or breast cancer. It is mainly designed to check safety and find the best way to give the treatment, and it may offer an option for people whose cancer has spread.

Predicting outcomes of CDK4/6 inhibitors plus hormone therapy for advanced breast cancer

This study looks at how well a type of targeted therapy (called CDK4/6 inhibitors) combined with hormone therapy works as the first treatment for advanced breast cancer that is hormone receptor-positive and HER2-negative. Researchers want to find patterns that could help predict which patients benefit most.

Radiation therapy for inoperable breast cancer

This trial tests whether definitive radiation therapy can effectively treat breast cancer that cannot be surgically removed. It may be an option for people whose cancer is inoperable or who choose not to have surgery.

Vaccine for Metastatic Breast Cancer

This trial tests a vaccine (MV-s-NAP) that is injected directly into a tumor to stimulate your immune system against breast cancer. It is for people with metastatic breast cancer that has spread despite prior treatments.

Radiation before surgery with breast reconstruction

This trial tests whether giving radiation therapy before surgery (instead of after) is safe and effective for women with breast cancer who also want immediate breast reconstruction. It could help avoid the need for a second surgery and improve recovery.

Personalized radiation therapy for early breast cancer

This trial is testing a way to personalize radiation therapy for people with early-stage breast cancer. It may help make treatment more precise and reduce side effects.

TRUDI trial for inflammatory breast cancer with HER2/low markers

This Phase 2 trial tests two medicines—durvalumab and trastuzumab deruxtecan—to treat stage III inflammatory breast cancer. It may help by controlling cancer growth using treatments aimed at specific breast cancer markers (HER2 positive or “HER2-low”).

Testing immune responses to anti-HER2 breast cancer treatments

This study looks at how your immune system reacts to anti-HER2 treatments in people with HER2-positive breast cancer. It may help doctors understand who responds best by studying immune signals in blood (and sometimes tissue) during or after treatment.

cmf chemotherapy for breast cancer in older adults

This trial tests a combination of three older chemotherapy drugs (cyclophosphamide, methotrexate, and fluorouracil, called CMF) for adults 70 and older with breast cancer. The goal is to see if this treatment is effective and well-tolerated in this age group.

Skin care program for breast cancer survivors on hormone therapy

This study tests whether a skin care program can improve the appearance of your skin and your quality of life while you take an aromatase inhibitor (a hormone therapy) after breast cancer treatment. It is designed for women who are starting this type of therapy for the first time.

Early breast cancer treatment patterns study

This study observes how doctors treat early breast cancer and what outcomes patients have. It's for people with hormone receptor-positive, HER2-negative breast cancer that hasn't spread to many lymph nodes.

Study drug for advanced ovarian and other solid cancers

This Phase 1/2 trial studies Rinatabart Sesutecan to treat advanced cancers, with special focus on certain ovarian cancer types. It’s meant for people whose cancer has come back or has not responded to prior treatments.

Immunotherapy plus radiation before breast cancer surgery

This trial tests combining two treatments—an immunotherapy drug (Toripalimab) and radiation—before surgery for a certain type of breast cancer (HR+, HER2-negative) that has spread to lymph nodes. The goal is to see if this combination helps shrink the tumor more than standard therapy alone.

Study of AKY-1189 for advanced solid tumors

This trial tests a new radioactive drug, AKY-1189, for people with solid tumors that have spread or cannot be removed. It may help if other treatments have stopped working.

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

CAR T-cell therapy for stomach and esophagus cancer

This trial tests a new treatment called CAR T-cell therapy that targets a protein called mesothelin found on some cancer cells. It is for people with advanced or recurrent cancer of the stomach or esophagus that has spread or come back after prior treatment.

Radiation therapy for breast cancer not responding to chemo

This trial tests whether adding a special type of radiation (SBRT) can help people whose breast cancer did not shrink after two rounds of standard chemotherapy. It's for people with stage II or III breast cancer that is still growing or stable.

Study of paclitaxel for patients with taxane-resistant solid tumors

This trial tests paclitaxel given as tiny micelle particles for people whose cancer (pancreatic, bile duct, lung, stomach, esophagus, or breast) stopped responding to taxane chemotherapy or did not shrink. The goal is to see if this treatment can help when standard taxanes no longer work.

Zongertinib for HER2-positive cancers that have spread

This trial tests a new pill called zongertinib, alone or with other drugs, for people with HER2-positive cancers (like breast, stomach, or colorectal cancer) that have spread and are no longer responding to standard treatments. The goal is to find the best dose and see if it can help shrink tumors or slow the disease.

A study of PF-08032562 for advanced solid tumors

This study tests a new medicine, PF-08032562, for people with advanced breast or colorectal cancer that has not responded to prior treatments. It aims to see if the drug is safe and can help shrink or slow the cancer.

Study of a new treatment for advanced cancers with a specific gene change

This trial tests a new type of therapy (NT-175) for people with certain advanced cancers that have a specific genetic change. It might help if your tumor has the TP53 R175H mutation and you have the HLA-A*02:01 immune marker.

BA1302 for advanced solid tumors

This trial tests a new drug, BA1302, for people with advanced solid tumors that have stopped responding to standard treatments. The study aims to see if BA1302 is safe and effective.

Chemotherapy effects on body reflexes after breast cancer treatment

This study looks at how chemotherapy affects the body's automatic reflexes, like heart rate and blood pressure control. It compares women who recently finished chemo for breast cancer with healthy women to understand side effects and recovery.

Study of MT-4561 for advanced solid tumors

This trial tests a new drug called MT-4561 in people with advanced solid tumors that have not responded to prior treatments. It aims to see if the drug can help shrink tumors or slow their growth.