Clinical trials
Breast Cancer Surgery clinical trials
Below are recruiting breast cancer surgery clinical trials, each written for real people, not researchers. We’re tracking 1,192 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04472845Recruiting
Shorter or longer breast radiation after surgery for high-risk cancer
This trial compares two schedules of radiation after breast surgery in people with high-risk, node-positive breast cancer. The goal is to see whether giving radiation in 1 week or 2 weeks works well and is safe after standard treatments.
ChandigarhAges 18 years+ - NCT04843865Recruiting
Chinese herbal add-on for joint pain from letrozole
This trial studies whether Chinese herbs, used alongside letrozole, can reduce ongoing joint and muscle pain or stiffness in postmenopausal women with hormone-receptor positive breast cancer. It’s mainly for people whose pain started or worsened after beginning letrozole and who have completed cancer treatments.
Bukit Bintang, Kuala LumpurAges 18 years+ - NCT04914663Recruiting
Exercise program during breast cancer chemotherapy
This study tests whether supervised exercise during chemotherapy is safe and helpful for people with early-stage breast cancer. It may support physical function and well-being while you are receiving cancer treatment.
Gainesville, FloridaAges 18–85 - NCT04990921RecruitingPhase 2
Palliative radiation plus pembrolizumab for metastatic breast cancer
This trial studies whether adding a focused, comfort-focused form of radiation (SBRT) to pembrolizumab can help people with stage IV breast cancer that cannot be removed with surgery. You may be eligible if you can receive palliative SBRT and have measurable tumors, and if you meet prior-therapy and blood/health criteria.
Louisville, KentuckyAges 18 years+ - NCT05035836RecruitingPhase 2
Test drug after early HER2-positive breast cancer surgery
This trial tests zanidatamab, a type of targeted antibody treatment, in people with early-stage HER2-positive breast cancer to see how well it works and how safe it is. Because it’s a single-arm pilot study, everyone in the study gets the drug, and you’ll likely be asked to undergo standard surgery if appropriate.
Houston, TexasAges 18 years+ - NCT05205200RecruitingPhase 2
Immune therapy for HR-positive, HER2-negative metastatic breast cancer
This Phase 2 trial studies an immune-based treatment for women with HR-positive and HER2-negative breast cancer that has spread or returned and can’t be cured with local treatment alone. The goal is to see whether the therapy can shrink tumors and improve disease control with acceptable safety.
ShanghaiAges 18–75 - NCT05317221Recruiting
Developing breast cancer tissue models for research
This trial builds lab “models” (called organoids) from breast cancer tissue to help researchers study different breast cancer types. You may be able to help by providing consent and meeting the study’s basic cancer and treatment history requirements.
MaastrichtAges 18 years+ - NCT05528133RecruitingPhase 2
Personalized radiation based on tumor genetics in triple-negative breast cancer
This trial tests whether using tumor “genetics” (information from your biopsy) to guide radiation planning can improve treatment for triple-negative breast cancer. It may help by aiming radiation more precisely while still using standard approaches where needed.
Clearwater, FloridaAges 18 years+ - NCT05740956RecruitingPhase 1
Drug study for cancers with HRR gene or HRD changes
This Phase 1 study tests HS-10502 in people with advanced solid tumors that have certain DNA repair problems (HRR or HRD). It may help by finding a safe dose and seeing whether the drug can shrink tumors in cancers that have specific genetic features.
Beijing, Beijing MunicipalityAges 18–75 - NCT05762900RecruitingPhase 2
Shorter breast radiation after surgery for low-risk breast cancer
This Phase 2 trial tests a shorter, focused radiation treatment after breast surgery, either alone or with an extra targeted boost. It’s for people with low-risk breast cancer and no spread to distant organs, aiming to keep results while reducing treatment time and side effects.
BeijingAges 35 years+ - NCT05798338Recruiting
Study blood samples and tiny cell particles in breast cancer
This study looks at tiny particles released by cells (called extracellular vesicles) in people with breast cancer. It may help researchers better understand breast cancer and how it behaves, which could improve future testing or treatments.
Pavia, LombardyAges 18–90 - NCT05961111RecruitingEarly Phase 1
Oncolytic virus injection for advanced solid tumors
This early-phase trial tests an injection of a virus designed to attack cancer cells in people with advanced solid tumors. It is meant for situations where standard treatments have not worked (or you can’t/won’t take them) and when doctors can directly deliver the treatment to a tumor spot.
Linyi, ShandongAges 18–75 - NCT06037954Recruiting
Mental health support for older adults with cancer
This study offers mental health care for older adults (65+) with breast, colorectal, lung, or prostate cancer who are getting treatment or recently finished. It aims to help people who are also feeling depressed.
New York, New YorkAges 65 years+ - NCT06048835Recruiting
Studying tumor cells in breast cancer patients
This trial looks at tumor cells in the blood of women with breast cancer to understand them better. It may help doctors learn more about how the disease spreads.
Pavia, LombardyAges 18–90 - NCT06055881Recruiting
Using radiation to delay changing treatment for breast cancer
This trial tests whether giving radiation to a few growing spots (1-3) can let you stay on your current drug longer, instead of switching to a new one right away. It's for people with metastatic breast cancer whose disease has been stable for months but now shows limited progression.
Scottsdale, ArizonaAges 18 years+ - NCT06081959RecruitingPhase 3
Study of SKB264 for advanced HR+/HER2- breast cancer
This trial tests a new drug called SKB264 for people with a common type of breast cancer (HR+/HER2-) that has spread or come back and has not responded to at least one round of chemotherapy. It aims to see if this treatment can help shrink tumors or slow the disease.
Beijing, Beijing MunicipalityAges 18–75 - NCT06105684RecruitingPhase 2
Low-dose capecitabine for advanced breast cancer
This trial tests a lower dose of the chemotherapy drug capecitabine in people with advanced breast cancer that is HER2 negative. It aims to see if this gentler dose works well, especially for older or frailer patients who may have more difficulty with standard treatment.
Birmingham, AlabamaAges 60 years+ - NCT06107673RecruitingPhase 2
Pill vs chemo before breast cancer surgery
This study compares taking a daily pill (dalpiciclib with hormone therapy) versus standard chemotherapy before breast cancer surgery. It's for postmenopausal women with a common type of early breast cancer that is strongly hormone-receptor positive and HER2-negative.
Shijiazhuang, HebeiAges 18–75 - NCT06143553RecruitingPhase 3
Paclitaxel micelles for metastatic breast cancer
This trial tests a new form of paclitaxel (a chemotherapy drug) for metastatic breast cancer that is HER2-negative. It may be an option if your cancer has returned or not improved after 2 to 4 previous treatments.
Nanjing, JiangsuAges 18 years+ - NCT06155305Recruiting
Organoid drug test before breast cancer surgery
This trial uses a lab-grown mini-tumor (organoid) from your biopsy to test which chemotherapy drugs work best for your cancer before you have surgery. The goal is to personalize your treatment and improve outcomes.
Hangzhou, ZhejiangAges 18–70 - NCT06169072RecruitingPhase 2
Finding lymph nodes with a tiny dose of magnetic tracer in breast cancer
This trial is testing whether a very small amount of a magnetic tracer called Magtrace can help find lymph nodes that need to be checked for cancer spread during breast cancer surgery.
GothenburgAges 18 years+ - NCT06308029Recruiting
E-health pain self-management for breast cancer survivors
This trial tests an online program to help people manage lasting pain after breast cancer treatment. It's designed for those whose pain still gets in the way of daily life, even after finishing primary treatment.
AntwerpAges 18 years+ - NCT06383767RecruitingPhase 3
A study of ESG401 for advanced HR+/HER2- breast cancer
This trial tests a new medicine called ESG401 for people with a common type of breast cancer (HR+/HER2-) that has spread and hasn't responded to at least one chemotherapy. The goal is to see if it works better than standard chemotherapy options.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06404697RecruitingPhase 2
Extra radiation to lymph nodes above collarbone for high-risk breast cancer
This trial tests giving a focused, higher dose of radiation to the lymph nodes above the collarbone after breast cancer treatment. It is for patients whose cancer did not fully disappear from those nodes after pre-surgery chemotherapy, to see if extra radiation can help prevent recurrence.
Shanghai, Shanghai MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for breast cancer surgery?
- Yes. Clin2 currently lists 1,192 recruiting breast cancer surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.