Clinical trials · Los Angeles, CA
Cancer clinical trials in Los Angeles
We’re tracking 996 recruiting cancer studies with a site in or near Los Angeles — including Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Los Angeles
- NCT07332507RecruitingPhase 1
Testing teclistamab for recurrent plasmablastic lymphoma
This trial tests a new drug called teclistamab for people with plasmablastic lymphoma that has come back or not responded to standard treatments. The goal is to see if teclistamab can shrink tumors and control the disease.
Los Angeles, CaliforniaAges 18 years+ - NCT07361510RecruitingPhase 3
Pumitamig vs Keytruda for advanced lung cancer with high PD-L1
This trial compares an experimental drug called Pumitamig with the approved immunotherapy drug Pembrolizumab (Keytruda) as the first treatment for advanced lung cancer that has high PD-L1 levels. The goal is to see which drug works better and has fewer side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT07605546Recruiting
Radiation Therapy for Cancer Pain Relief
This trial tests whether a focused radiation treatment called SRS (stereotactic radiosurgery) can help relieve severe cancer pain that hasn't improved with strong pain medications. You would receive a one-time radiation procedure aimed at pain-causing areas in your brain.
Los Angeles, CaliforniaAges 18 years+ - NCT06790693RecruitingPhase 3
Inavolisib plus hormone therapy for advanced breast cancer
This trial tests a new targeted therapy, inavolisib, combined with standard hormone therapy and a CDK4/6 inhibitor for people with a specific genetic mutation (PIK3CA) in their hormone receptor-positive, HER2-negative advanced breast cancer that has not been treated before. It compares this combination to a placebo plus the same standard treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT02970045Recruiting
USC care program for cancer patients enrolled at Norris
This trial is part of a cancer care program for people receiving outpatient or inpatient care at USC Norris. It helps enroll patients into the program’s care and research paperwork, with consent available in English or Spanish.
Los Angeles, CaliforniaAges 18 years+ - NCT07200830RecruitingPhase 3
Testing different schedules of a targeted radiation drug for advanced prostate cancer
This trial tests two different dosing schedules of a drug called Lutetium-177 PSMA RLT, which delivers radiation directly to prostate cancer cells. It is for men with advanced prostate cancer that has stopped responding to hormone therapy and has spread, who have not yet had chemotherapy for this stage of the disease.
Los Angeles, CaliforniaAges 18 years+ - NCT02701153Recruiting
Short pre-surgery radiation for soft-tissue sarcoma
This trial tests a short course of radiation before surgery to shrink a soft-tissue sarcoma and make it easier to remove. It may help by improving how well the tumor can be removed, while studying safety and effectiveness for this cancer type.
Los Angeles, CaliforniaAges 18 years+ - NCT06842498RecruitingPhase 2
FG-3246 for advanced prostate cancer
This trial tests a new drug called FG-3246, which targets a protein (CD46) on prostate cancer cells. It's for men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy, and who have had limited prior treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT05828069RecruitingPhase 2
Tovorafenib for young people with worsening Langerhans cell histiocytosis
This Phase 2 trial tests tovorafenib (DAY101) to treat children and young people whose Langerhans cell histiocytosis (LCH) is getting worse, came back, or did not respond to prior treatment. It may help by targeting certain gene changes found in the LCH.
Los Angeles, CaliforniaAges 6 months–22 years - NCT05812807RecruitingPhase 3
Pembrolizumab versus monitoring after triple-negative breast cancer response
This trial checks whether giving pembrolizumab (an immunotherapy) after surgery helps people with triple-negative breast cancer reduce the chance of the cancer coming back, compared with close monitoring only. It’s for patients who had no remaining invasive cancer after neoadjuvant chemotherapy plus pembrolizumab.
Los Angeles, CaliforniaAges 18 years+ - NCT07736937RecruitingPhase 1/Phase 2
Study of TUB-040 with Standard Drugs for Ovarian Cancer
This study tests a new medicine called TUB-040, given together with standard ovarian cancer drugs like carboplatin and bevacizumab. It is for women with ovarian cancer that has returned after responding to platinum-based chemotherapy and is growing again. The goal is to see if this combination can help control the cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT07195734RecruitingPhase 2
Adding chemo or immunotherapy before surgery for advanced head and neck cancer
This trial tests whether giving chemotherapy or chemotherapy plus immunotherapy before surgery can improve outcomes for people with advanced head and neck cancer that has come back or not gone away after prior treatment.
Los Angeles, CaliforniaAges 18 years+ - NCT06764940RecruitingPhase 2
Utidelone and capecitabine for HER2-negative breast cancer with brain metastases
This trial tests if the combination of Utidelone and capecitabine can shrink brain metastases in people with HER2-negative breast cancer. It is designed for those whose cancer has spread to the brain and who have not had many prior treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT02693535RecruitingPhase 2
Targeted drug testing for advanced cancer with tumor gene changes
This trial tests whether FDA-approved targeted drugs can help people with advanced cancer whose tumors have specific gene changes. It aims to match your tumor's unique genetic profile to a drug that may work better for you.
Los Angeles, CaliforniaAges 12 years+ - NCT05190978Recruiting
Test mesh use for breast reconstruction above the muscle
This study tests whether using surgical mesh can be done safely and works well in breast reconstruction done right away, in front of the chest muscle (pre-pectoral) using tissue expanders. It may help improve how the reconstructed area holds up, but you’d need to meet specific surgical and health requirements.
Los Angeles, CaliforniaAges 22–75 - NCT07524322RecruitingPhase 1
RGT-490 for Advanced Cancers With PIK3CA Mutations
This study tests a new drug called RGT-490 in patients with advanced solid tumors (cancers that have spread or cannot be removed by surgery) that have a specific genetic change called a PIK3CA mutation. The drug is designed to block a protein involved in cancer cell growth.
Los Angeles, CaliforniaAges 18 years+ - NCT07309445Recruiting
Real-world use of TAR-200 for non-muscle invasive bladder cancer
This study looks at how patients with non-muscle invasive bladder cancer are using TAR-200 in everyday medical care. It aims to understand treatment patterns and outcomes outside of a clinical trial.
Los Angeles, CaliforniaAges 18 years+ - NCT07216105RecruitingPhase 1
New immune cell treatment for advanced solid tumors
This trial tests a new treatment using specially engineered immune cells (called FT836) for people with advanced solid tumors that have not responded to other treatments. It may be given alone or with chemotherapy and/or other antibody medicines. The study aims to see if this approach can shrink tumors or slow their growth.
Los Angeles, CaliforniaAges 18 years+ - NCT06090903Recruiting
MRI Study to Understand Glioblastoma Biology Before Surgery
This study uses MRI scans to learn more about the biology of glioblastoma before and after surgery. It may help doctors understand how the tumor behaves and improve future treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT05890352RecruitingPhase 2
Add new medicines to standard treatment for returning lymphoma
This Phase 2 study tests whether adding tafasitamab, lenalidomide, tazemetostat, and zanubrutinib (along with standard lymphoma treatment) can improve outcomes in people whose large B-cell lymphoma has returned or not responded. It may help control disease more effectively and improve response duration for eligible patients.
Los Angeles, CaliforniaAges 18 years+ - NCT03603223RecruitingPhase 2
Pembrolizumab for abnormal mouth patches that may become cancer
This Phase 2 trial studies pembrolizumab (an immune medicine) for leukoplakia and related abnormal mouth patches with moderate/severe pre-cancer changes. It aims to see whether the treatment can shrink or control the lesions when surgery or radiation isn’t an option.
Los Angeles, CaliforniaAges 18 years+ - NCT04205968RecruitingPhase 2
Testing ramucirumab with chemo for advanced small bowel cancer
This trial studies whether adding ramucirumab to chemotherapy (either paclitaxel or FOLFIRI) works better for advanced small bowel adenocarcinoma that has already been treated with certain prior medicines. It may help shrink tumors or slow cancer growth in people whose cancer has progressed.
Los Angeles, CaliforniaAges 18 years+ - NCT05614739RecruitingPhase 1
Study of vepugratinib for cancers with FGFR3 gene changes
This study tests a new pill, vepugratinib, for people whose cancer has a specific change in a gene called FGFR3. The drug targets this gene change to try to slow or shrink the cancer, and may be an option if standard treatments have not worked.
Los Angeles, CaliforniaAges 18 years+ - NCT07817147Recruiting
Microwave ablation treatment for advanced cancer
This study tests a procedure called microwave ablation (using heat to destroy cancer cells) for tumors that are hard to remove with surgery. It aims to see if the procedure is safe and effective when done through a scope in the stomach.
Los Angeles, CaliforniaAges 18 years+
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Cancer trials in other cities
Where these studies are running near Los Angeles
Institutions with a site for the recruiting cancer studies listed above.
- Cedars-Sinai Medical Center · 5 studies
- USC Norris Comprehensive Cancer Center · 5 studies
- City of Hope · 4 studies
- UCLA Jonsson Comprehensive Cancer Center · 4 studies
- UC Irvine Health/Chao Family Comprehensive Cancer Center · 3 studies
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · 3 studies
- Loma Linda University Medical Center · 2 studies
- Providence Saint Joseph Medical Center/Disney Family Cancer Center · 2 studies
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting cancer studies in California.
Common questions
- Are there cancer clinical trials near Los Angeles?
- Yes. We're currently tracking 996 recruiting cancer studies with a site near Los Angeles, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study near Los Angeles?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Los Angeles to take part?
- Not necessarily. These studies have a site near Los Angeles, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open near Los Angeles regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.