Clinical trials · Philadelphia, PA
Cancer clinical trials in Philadelphia
We’re tracking 615 recruiting cancer studies with a site in or near Philadelphia — including Phase 1, Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Philadelphia
- NCT01870752Recruiting
Transplanting frozen ovarian tissue to help you try for pregnancy
This trial studies whether thawed, previously frozen ovarian tissue can be transplanted to help people with ovarian insufficiency become pregnant. It may help if you already have cryopreserved ovarian tissue stored and your care team feels you’re a good candidate for the procedure.
Philadelphia, PennsylvaniaAges 18–45 - NCT04119713Recruiting
Study how the immune system changes after cancer immunotherapy
This study looks at what happens to your immune system after you start a type of cancer treatment called a checkpoint inhibitor. The goal is to better understand side effects related to “autoimmunity” (when the immune system starts attacking the body) and improve care.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06413355RecruitingPhase 1
FAPI-74 PET scan for adults with fibrosis
This study tests a new type of PET/CT scan (FAPI-74) to see if it can detect areas of scarring (fibrosis) in the body. It may help doctors better understand and monitor conditions like certain cancers, infections after transplants, and heart inflammation.
Philadelphia, PennsylvaniaAges 21 years+ - NCT07215910RecruitingPhase 3
Testing vorasidenib with temozolomide after radiation for advanced brain cancer
This trial tests whether adding the targeted drug vorasidenib to standard chemotherapy (temozolomide) after radiation helps people with a specific type of advanced brain cancer called IDH-mutant astrocytoma. It is for patients who have not had previous treatments like chemotherapy or radiation and whose tumors have certain genetic features.
Philadelphia, PennsylvaniaAges 12 years+ - NCT04166409RecruitingPhase 3
Selumetinib versus chemo for low-grade brain tumor in children
This trial studies whether the targeted drug selumetinib works better than standard chemotherapy (carboplatin and vincristine) for children and young adults with a specific type of low-grade glioma (grade 1 or 2). It may help shrink tumors and slow growth while comparing side effects between the two treatment approaches.
Philadelphia, PennsylvaniaAges 2–21 - NCT04181060RecruitingPhase 3
Osimertinib alone or with bevacizumab for EGFR-mutant lung cancer
This Phase 3 trial tests whether starting osimertinib with or without bevacizumab helps people with advanced EGFR-mutant lung cancer live longer and control the cancer better. Your EGFR mutation test result and past treatments are key to whether you can join.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06161025RecruitingPhase 2/Phase 3
Raludotatug Deruxtecan for resistant ovarian cancer
This study tests a new drug called Raludotatug Deruxtecan (R-DXd) for people with ovarian, fallopian tube, or primary peritoneal cancer that has stopped responding to platinum-based chemotherapy. The goal is to see if R-DXd can shrink tumors or slow cancer growth.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04970056Recruiting
Pancreatic cancer risk and early-detection registry study
This study builds a database of people at higher risk for pancreatic cancer (or certain early warning findings) to help find better ways to detect the disease early. You may be asked to complete health questionnaires and possibly donate a blood/saliva/swab sample.
Philadelphia, PennsylvaniaAges 18–90 - NCT06410209RecruitingPhase 2
Walking Juntos: Smartphone program to help Hispanic cancer survivors be active
This study will test if a smartphone program and social media group can help Hispanic/Latino teens and young adults who had childhood cancer become more physically active. You would wear a Fitbit and use a phone app with culturally tailored tips and support.
Philadelphia, PennsylvaniaAges 15–20 - NCT06317662RecruitingPhase 2
Adding venetoclax and blinatumomab to chemo for infant leukemia
This trial tests adding two newer medicines (venetoclax and blinatumomab) to standard chemotherapy for infants with a specific type of leukemia. The goal is to see if this combination helps more babies stay cancer-free.
Philadelphia, PennsylvaniaAges Up to 12 months - NCT06837480Recruiting
Light therapy for long-term swelling after head and neck cancer
This study tests a light-based treatment called photobiomodulation (PBMT) to help reduce chronic swelling after head and neck cancer therapy. It is for people whose swelling hasn’t improved with standard treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06423573Recruiting
Skin cancer risk in epidermolysis bullosa patients using Filsuvez
This study tracks anyone with dystrophic or junctional epidermolysis bullosa who is using Filsuvez gel to see how often skin cancers appear. It is designed to understand the long-term safety of the treatment.
Philadelphia, PennsylvaniaAges Any age - NCT05274048RecruitingPhase 1
Neratinib plus antibody-drug for HER2-positive stomach or esophagus cancer
This early-phase trial tests neratinib together with an antibody-drug to treat advanced HER2-positive gastro-esophageal (stomach/esophagus) cancer that can’t be removed by surgery. It’s for people whose cancer has progressed after at least one HER2-targeted treatment, aiming to shrink tumors and improve outcomes.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06424327Recruiting
Lung cancer surgery registry
This study collects information from people having surgery to remove a small part of the lung (segmentectomy) for early-stage lung cancer. It helps doctors learn more about this surgery and its outcomes.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04871542Recruiting
Predicting risk of immune therapy side effects
This study tries to predict who is more likely to get serious side effects from immune checkpoint medicines used for solid tumors. You may help researchers by answering questionnaires before treatment and during follow-up, and by possibly storing sample specimens.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06430788RecruitingPhase 2
Emapalumab for children with severe aplastic anemia
This trial tests whether a medication called emapalumab can help children with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. It combines emapalumab with standard immune-suppressing therapy to try to improve blood cell counts.
Philadelphia, PennsylvaniaAges birth–25 years - NCT04468061RecruitingPhase 2
Study chemo drug plus immunotherapy for metastatic triple-negative breast cancer
This trial tests sacituzumab govitecan (an antibody-drug medicine) with or without pembrolizumab (an immune-system therapy) in people with metastatic triple-negative breast cancer. It may help by shrinking tumors and improving immune control, especially for patients with specific tumor marker results.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04924075RecruitingPhase 2
Belzutifan for cancers linked to VHL or HIF-2α changes
This Phase 2 study tests belzutifan (MK-6482) to treat certain advanced cancers caused by specific gene or disease changes, including VHL-related tumors and HIF-2α related tumors. It may help shrink tumors or slow their growth in people whose cancer matches these genetic or disease patterns.
Philadelphia, PennsylvaniaAges 12 years+ - NCT05668962RecruitingPhase 2
Study selpercatinib plus I-131 for RET thyroid cancer that cannot take iodine
This trial tests whether combining a targeted pill (selpercatinib) with a radioactive iodine dose (I-131) can shrink thyroid cancer that has spread and no longer responds to radioactive iodine. It is for RET fusion–positive (genetically driven) thyroid cancers where the cancer cannot reliably absorb iodine anymore.
Philadelphia, PennsylvaniaAges 12 years+ - NCT04949464Recruiting
Smoking quit coaching plus lung scans for people with HIV
This study tests a behavior-change program to help people with HIV quit smoking, along with routine low-dose lung CT scans to find warning signs early. It’s a feasibility study, meaning the main goal is to see if the approach is practical and acceptable, and if people can follow through.
Philadelphia, PennsylvaniaAges 45–80 - NCT04511806Recruiting
Study of inherited cancer risk in children and families
This study looks at how inherited “cancer predisposition” conditions run in families, even if a child has not had cancer yet. It may help doctors better understand who is at higher risk and guide future monitoring or care.
Philadelphia, PennsylvaniaAges Any age - NCT05031910Recruiting
Virtual 3D guidance for head and neck cancer surgery
This study tests whether a virtual reality (3D computer) model of surgery can help surgeons improve how head and neck cancer operations are planned and done. You may benefit from more personalized surgical planning, if you’re eligible for standard surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06888388Recruiting
Safety of nipple-sparing mastectomy for women with high-risk genes
This study looks at the long-term safety of a type of breast surgery (nipple-sparing mastectomy) in women who carry certain inherited gene changes (BRCA1, BRCA2, PALB2, TP53, CDH1, or PTEN) that increase their risk of breast cancer. The goal is to understand how safe this surgery is over time for these women.
Philadelphia, PennsylvaniaAges 18–90 - NCT05683418RecruitingPhase 1
Study of a new drug for PIK3CA-mutated HR+ HER2- breast cancer
This early-stage study tests the safety and tolerability of TOS-358 in women with HR-positive, HER2-negative breast cancer that has a specific gene change (PIK3CA). It may help learn whether this targeted treatment is safe enough to move forward.
Philadelphia, PennsylvaniaAges 18 years+
Hear when a new Cancer trial opens near Philadelphia, PA
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Cancer trials in other cities
Where these studies are running near Philadelphia
Institutions with a site for the recruiting cancer studies listed above.
- Children's Hospital of Philadelphia · 5 studies
- University of Pennsylvania · 4 studies
- Alfred I duPont Hospital for Children · 3 studies
- Christiana Care Health System-Concord Health Center · 3 studies
- Fox Chase Cancer Center · 3 studies
- Helen F Graham Cancer Center · 3 studies
- Lehigh Valley Hospital-Cedar Crest · 3 studies
- Medical Oncology Hematology Consultants PA · 3 studies
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting cancer studies in Pennsylvania.
Common questions
- Are there cancer clinical trials near Philadelphia?
- Yes. We're currently tracking 615 recruiting cancer studies with a site near Philadelphia, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study near Philadelphia?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Philadelphia to take part?
- Not necessarily. These studies have a site near Philadelphia, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open near Philadelphia regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.