Clinical trials · Philadelphia, PA
Cancer clinical trials in Philadelphia
We’re tracking 622 recruiting cancer studies with a site in or near Philadelphia — including Early Phase 1, Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Philadelphia
- NCT05758688RecruitingPhase 2
Proton radiation after surgery for uterine or cervical cancer
This trial studies whether proton beam radiation after surgery can better treat certain uterine (endometrial) or cervix (cervical) cancers. It may help by targeting the pelvic area while limiting radiation to nearby organs.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06948448RecruitingPhase 2
New treatment for advanced colorectal cancer with PD-L1 biomarker
This trial tests a new drug (ONO-4578) combined with standard chemotherapy and immunotherapy for people with advanced colorectal cancer that has not been treated before and has a specific marker called PD-L1. The goal is to see if this combination works better than the usual treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07044336RecruitingPhase 3
Comparing a new drug to chemo for advanced endometrial cancer
This trial tests a new investigational drug called Puxitatug Samrotecan (AZD8205) against standard chemotherapy in people whose endometrial cancer has come back or spread after prior treatment with platinum chemo and an immunotherapy. The goal is to see if the new drug works better.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06077760RecruitingPhase 3
Personalized cancer vaccine plus Keytruda for lung cancer after surgery
This study tests a new personalized cancer vaccine (V940) plus Keytruda versus a placebo plus Keytruda for people with non-small cell lung cancer that was removed by surgery. The goal is to see if the vaccine helps prevent the cancer from coming back.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05887609RecruitingPhase 2
Maintenance treatment for FRalpha-positive ovarian or endometrial cancer
This Phase 2 trial tests a combination of two medicines (mirvetuximab soravtansine and olaparib) as ongoing “maintenance” treatment after your best response to prior platinum chemotherapy. It may help keep cancer from growing longer in certain women whose tumors strongly match a specific marker (FRalpha).
Philadelphia, PennsylvaniaAges 18–100 - NCT02081755Enrolling by invitationPhase 4
Everolimus after liver transplant to lower liver cancer return
This trial studies whether everolimus, a transplant medicine, can safely reduce the chance that liver cancer comes back after liver transplant. It compares how well the treatment works while carefully monitoring side effects and safety.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07276789RecruitingPhase 2
Single-dose dye imaging for lung cancer surgery
This trial tests a single dose of a special dye (LS301-IT) that helps surgeons see lung cancer cells more clearly during surgery. It aims to make lung cancer removal more precise and complete.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07326566RecruitingPhase 2
Silevertinib and chemo for a type of glioblastoma
This trial tests a new drug, silevertinib, combined with temozolomide (a chemotherapy) for people with a newly diagnosed glioblastoma that has certain genetic markers. It aims to see if this combination works better than standard treatment for tumors with these specific features.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07174336RecruitingPhase 3
Testing Tersolisib with other treatments for advanced breast cancer
This trial tests a new study drug called Tersolisib combined with other anti-cancer treatments for people with advanced breast cancer that has a specific gene change (PIK3CA). The goal is to see if the combination can help shrink or slow the cancer.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04142437Recruiting
Tracking how larotrectinib works for NTRK fusion cancers in routine care
This study follows people with cancers that have an NTRK gene fusion to learn how safe and effective larotrectinib is during everyday treatment. It may help confirm whether this medicine works well in real-world patients and side effects stay manageable.
Philadelphia, PennsylvaniaAges Any age - NCT07278986RecruitingEarly Phase 1
Imaging dye during endometrial cancer surgery
This trial tests a dye (CYTALUX) that helps surgeons see endometrial cancer during surgery. You may be eligible if you have endometrial cancer and are scheduled for surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06306638RecruitingPhase 1/Phase 2
Light therapy after radiation for inoperable airway tumors
This trial tests a new light-activated therapy (interstitial photodynamic therapy) after palliative radiation to shrink inoperable airway tumors and improve breathing. It is for people with solid cancers that block the airway from the outside and cannot be removed with surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06317662RecruitingPhase 2
Adding venetoclax and blinatumomab to chemo for infant leukemia
This trial tests adding two newer medicines (venetoclax and blinatumomab) to standard chemotherapy for infants with a specific type of leukemia. The goal is to see if this combination helps more babies stay cancer-free.
Philadelphia, PennsylvaniaAges Up to 12 months - NCT06126276RecruitingPhase 2
Testing neratinib with or without palbociclib for HER2+ solid tumors
This trial tests two targeted drugs—neratinib alone or with palbociclib—for people with HER2-positive solid tumors (other than breast cancer) that have returned or not gone away. The goal is to see if blocking HER2 and CDK4/6 can shrink or slow the tumor.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05852860Enrolling by invitation
Mentoring program for HIV clinicians on tobacco cessation
This study tests a mentoring program to help clinicians who care for HIV patients learn more about helping patients quit smoking. It aims to improve how doctors and nurses support tobacco cessation in HIV care.
Philadelphia, PennsylvaniaAges Any age - NCT04523857RecruitingPhase 2
Abemaciclib and hydroxychloroquine after breast cancer relapse risk
This Phase 2 trial tests whether abemaciclib plus hydroxychloroquine can kill tiny “leftover” cancer cells in the bone marrow after standard breast cancer treatment. It may help lower the chance of cancer coming back by targeting minimal residual disease.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06122077Recruiting
Blood test for early lung cancer detection in smokers
This trial tests a blood test that looks for multiple signals to find lung cancer early. If you are a smoker or former smoker over 50, this test might help detect cancer before you have symptoms.
Philadelphia, PennsylvaniaAges 50 years+ - NCT05174169RecruitingPhase 2/Phase 3
Adjuvant colon chemotherapy guided by tumor DNA results
This trial tests whether treatment for colon cancer after surgery can be guided by a blood test that looks for leftover cancer signals (ctDNA). It may help some people choose stronger or different chemo based on whether ctDNA is found after surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT02984761Recruiting
Surgery vs focused radiation for early lung cancer
This trial compares two ways to treat early-stage lung cancer: surgery or a precise type of radiation called stereotactic radiotherapy. It aims to find out which approach works best for people whose cancer is small and has not spread.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04633239RecruitingPhase 1
Testing abemaciclib plus olaparib for recurrent ovarian cancer
This Phase 1 trial studies whether adding abemaciclib to olaparib can treat women with recurrent platinum-resistant ovarian cancer. It aims to find a safe dose and see how well the combination can control the cancer.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06458036RecruitingPhase 2
Selpercatinib before radioactive iodine for RET-positive thyroid cancer
This study tests whether a targeted drug called selpercatinib, taken before radioactive iodine therapy, can help treat thyroid cancer in children and young adults who have a specific genetic change (RET fusion or mutation). The drug may make the cancer more sensitive to the radioactive iodine treatment that follows.
Philadelphia, PennsylvaniaAges 2–25 - NCT06914557RecruitingPhase 2
Scrambler therapy plus duloxetine for chemo nerve pain
This study tests whether adding a non-invasive device called Scrambler Therapy to the usual nerve pain medicine (duloxetine) can better relieve chemotherapy-induced nerve pain. It is for people with cancer who still have significant nerve pain despite taking duloxetine.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06055439RecruitingPhase 1/Phase 2
CAR T cell therapy for GI cancers
This trial tests a new type of immunotherapy called CAR T cells that target a protein (CDH17) found on certain stomach, colon, and rectal cancers. It's designed for people whose cancer has spread and has been treated before.
Philadelphia, PennsylvaniaAges 18–85 - NCT07715188Recruiting
Low dose radiation for osteoarthritis
This trial tests if a very low dose of radiation can help relieve pain from osteoarthritis in joints like hips, knees, hands, shoulders, ankles, or elbows. It is for people whose pain has not improved with standard treatments or who want to try a gentler option before considering surgery.
Philadelphia, PennsylvaniaAges 18 years+
Hear when a new Cancer trial opens near Philadelphia, PA
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Cancer trials in other cities
Where these studies are running near Philadelphia
Institutions with a site for the recruiting cancer studies listed above.
- University of Pennsylvania · 12 studies
- Thomas Jefferson University Hospital · 7 studies
- Asplundh Cancer Pavilion · 3 studies
- Children's Hospital of Philadelphia · 3 studies
- Fox Chase Cancer Center · 2 studies
- Jefferson Cherry Hill Hospital · 2 studies
- Lehigh Valley Hospital-Cedar Crest · 2 studies
- Sidney Kimmel Cancer Center at Washington Township · 2 studies
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting cancer studies in Pennsylvania.
Common questions
- Are there cancer clinical trials near Philadelphia?
- Yes. We're currently tracking 622 recruiting cancer studies with a site near Philadelphia, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study near Philadelphia?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Philadelphia to take part?
- Not necessarily. These studies have a site near Philadelphia, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open near Philadelphia regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.