Clinical trials · Florida
Cancer clinical trials in Florida
We’re tracking 1,009 recruiting cancer studies with a site in Florida — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Florida
- NCT06122077Recruiting
Blood test for early lung cancer detection in smokers
This trial tests a blood test that looks for multiple signals to find lung cancer early. If you are a smoker or former smoker over 50, this test might help detect cancer before you have symptoms.
DeLand, FloridaAges 50 years+ - NCT06137274RecruitingPhase 2
Adaptive radiation boost for head and neck cancer
This trial tests a new way of giving radiation therapy, called adaptive radiation boost, for people with head and neck cancer. The goal is to see if this approach can better target the cancer and possibly improve outcomes.
Tampa, FloridaAges 18 years+ - NCT06148298Recruiting
Using a blood test to find pancreatic cancer
This study is testing a new blood test that looks for DNA changes to help find pancreatic cancer. It may lead to a way to find cancer earlier.
Orlando, FloridaAges 18 years+ - NCT06170788RecruitingPhase 3
New Two-Drug Immunotherapy Combo vs. Standard Immunotherapy for Advanced Lung Cancer
This study compares a new combination of two immunotherapy drugs (sacituzumab tirumotecan plus pembrolizumab) versus pembrolizumab alone for people with advanced non-small cell lung cancer that has a high PD-L1 level (≥50%) and has not been treated yet. The goal is to see if the combination works better than the standard single immunotherapy.
Jacksonville, FloridaAges 18 years+ - NCT06174987RecruitingPhase 3
Extended access study for patients benefiting from DS drugs
This study allows people who are already in a Daiichi Sankyo trial and getting benefit from the study drug to continue receiving it safely. It monitors long-term safety for those who have not had their cancer worsen.
Miami, FloridaAges 18 years+ - NCT06190886RecruitingPhase 1
First-in-human study of PTX-912 for advanced solid tumors
This trial tests a new drug called PTX-912 for people with advanced or metastatic solid tumors that have not responded to standard treatments. It is a first-in-human study, meaning this is the first time PTX-912 is being given to people, to see how safe it is and how well it works.
Miami, FloridaAges 18 years+ - NCT06218914RecruitingPhase 1
Study of a new treatment for KRAS G12D cancers
This trial tests a new type of cell therapy (called TCR-T) that targets a specific genetic change (KRAS G12D) in advanced solid tumors that have stopped responding to standard treatments. It may be an option if your cancer has this mutation and you have a specific tissue type (HLA).
Jacksonville, FloridaAges 18 years+ - NCT06234423RecruitingPhase 1
A study of CUSP06 for advanced solid tumors
This study tests a new drug called CUSP06 for people with advanced solid tumors, especially ovarian cancer that has stopped responding to platinum chemotherapy. It may help if standard treatments no longer work.
Sarasota, FloridaAges 18 years+ - NCT06236438RecruitingPhase 2/Phase 3
Livmoniplimab plus budigalimab and chemo for untreated lung cancer
This trial tests a new combination of two immune system drugs (livmoniplimab and budigalimab) plus standard chemotherapy compared to the current standard treatment (pembrolizumab plus chemo) for people with advanced non-small cell lung cancer that has not been treated yet. The goal is to see if the new combination works better at controlling the cancer.
Pembroke Pines, FloridaAges 18 years+ - NCT06267729RecruitingPhase 1/Phase 2
A new cell therapy for advanced prostate cancer
This trial tests a new cell therapy (AZD0754) for metastatic prostate cancer that has stopped responding to standard hormone therapy and chemotherapy. It’s looking for people whose cancer has gotten worse despite prior treatments, and who are still in fairly good health.
Tampa, FloridaAges 18–130 - NCT06276491RecruitingPhase 1
XmAb541 for advanced solid tumors
This phase 1 trial tests a new drug, XmAb541, for people with advanced solid tumors (ovarian, endometrial, or germ cell tumors) that have not responded to previous treatments. The trial focuses on people whose tumors have a specific protein called CLDN6 and aims to find a safe and effective dose.
Tampa, FloridaAges 15 years+ - NCT06282575RecruitingPhase 3
Zanidatamab plus chemo for advanced HER2-positive bile duct cancer
This phase 3 trial tests whether adding zanidatamab (a targeted antibody) to standard chemotherapy can improve outcomes for advanced HER2-positive biliary tract cancer. If you have this type of cancer that has spread or can't be removed, and you've had little or no prior treatment, this study might be an option.
Orlando, FloridaAges 18 years+ - NCT06309225Recruiting
Adjusted Chemoradiation for HPV Throat Cancer in Older Adults
This trial tests adjusting the dose of chemotherapy and radiation for older adults (65+) with HPV-related throat cancer. The goal is to find a treatment that is effective but gentler on the body.
Jacksonville, FloridaAges 65–99 - NCT06319820RecruitingPhase 3
TAR-210 vs standard bladder chemo for FGFR-mutated bladder cancer
This trial compares a new drug, TAR-210, which is placed directly into the bladder, against standard chemotherapy given through a catheter. It is for people with a specific type of bladder cancer that has a change in the FGFR gene.
Tampa, FloridaAges 18 years+ - NCT05856773RecruitingPhase 3
Standard vs shorter radiation to lymph nodes for breast cancer
This trial compares two ways of giving radiation to the breast/chest wall and nearby lymph nodes after breast surgery: a standard schedule versus a shorter “hypofractionated” schedule. It uses proton therapy and may help reduce treatment time while still controlling the cancer.
Jacksonville, FloridaAges 19 years+ - NCT07694986RecruitingPhase 2
Vaccine therapy for breast cancer that has spread to the brain and spinal cord
This trial tests a new type of vaccine (dendritic cells) injected directly into the spinal fluid, combined with either trastuzumab (if your breast cancer is HER2-positive) or nivolumab (if your breast cancer is HER2-negative). The goal is to see if this combination can better control breast cancer that has spread to the lining of the brain and spinal cord.
Tampa, FloridaAges 18 years+ - NCT06422143RecruitingPhase 3
Keytruda with or without Sac-TMT for advanced squamous lung cancer
This trial tests the combination of pembrolizumab (Keytruda) with or without a new drug, sacituzumab tirumotecan (Sac-TMT), as initial treatment for advanced squamous non-small cell lung cancer. It aims to see if adding Sac-TMT after initial treatment helps keep cancer under control longer.
Orange City, FloridaAges 18 years+ - NCT07357597RecruitingPhase 4
Preventing mouth sores during breast or lung cancer treatment
This trial tests whether a steroid mouthwash can prevent mouth sores caused by the drug Datopotamab Deruxtecan (Dato-DXd). It is for people with certain types of advanced breast cancer or lung cancer who are about to start Dato-DXd for the first time.
Plantation, FloridaAges 18 years+ - NCT07502352Recruiting
Online stress management for breast cancer survivors
This study tests a remotely-delivered program to help you manage stress after breast cancer treatment. It is for women who are 50 or older, have completed treatment for a specific type of breast cancer, and currently take hormone therapy.
Coral Gables, FloridaAges 50 years+ - NCT07023289RecruitingPhase 2
Study of Telisotuzumab Adizutecan for ctDNA-Positive Colorectal Cancer
This trial tests a new drug, Telisotuzumab Adizutecan, given through a vein (infusion) alone or with standard treatments for people with colorectal cancer who have no visible tumors on scans but still have cancer DNA (ctDNA) in their blood after surgery and chemotherapy.
Jacksonville, FloridaAges 18 years+ - NCT06327490RecruitingPhase 2
ICG-guided vs. traditional lymphatic drainage for breast cancer surgery
This trial compares a new imaging method (ICG) to the standard method for manual lymphatic drainage during breast cancer surgery. It aims to reduce swelling in the arm after lymph node removal.
Gainesville, FloridaAges 18–99 - NCT06345729RecruitingPhase 3
Study of Calderasib and Pembrolizumab for Advanced Lung Cancer
This trial tests a new combination of two drugs (Calderasib and Pembrolizumab) in people with a specific type of advanced lung cancer (non-small cell lung cancer) that has a KRAS G12C mutation and high PD-L1 levels. It aims to see if this treatment can help shrink or control the cancer.
Miami Beach, FloridaAges 18 years+ - NCT06346782Recruiting
Online parenting support for children with cancer
This study tests an online therapy program that helps parents manage challenging behaviors in children with cancer. If you join, you'll learn skills through video coaching sessions with a therapist, all from the comfort of your home.
St. Petersburg, FloridaAges Any age - NCT06350097RecruitingPhase 3
Osimertinib with or without another drug for advanced EGFR-mutant lung cancer
This trial tests whether adding a new drug (datopotamab deruxtecan) to the standard targeted therapy osimertinib works better for advanced non-small cell lung cancer with certain EGFR mutations. It is for people who have not had chemotherapy or targeted therapy before.
Jacksonville, FloridaAges 18 years+
Cancer trials by city in Florida
Where these studies are running in Florida
Institutions with a site for the recruiting cancer studies listed above.
- H. Lee Moffitt Cancer Center and Research Institute · 5 studies
- Research Site · 4 studies
- Mayo Clinic · 2 studies
- Miami Cancer Institute · 2 studies
- Mount Sinai Medical Center · 2 studies
- AdventHealth Orlando
- Baptist MD Anderson Cancer Center
- Bond Clinic
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cancer trials in other states
Common questions
- Are there cancer clinical trials in Florida?
- Yes. We're currently tracking 1,009 recruiting cancer studies with a site in Florida, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study in Florida?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Florida to take part?
- Not necessarily. These studies have a site in Florida, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open in Florida regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.