Clinical trials · Pennsylvania
Cancer clinical trials in Pennsylvania
We’re tracking 831 recruiting cancer studies with a site in Pennsylvania — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT07737951Recruiting
Tai chi for joint pain from breast cancer hormone therapy
This trial tests whether tai chi can help reduce joint pain caused by aromatase inhibitors, which are hormone therapies for breast cancer. If you have joint pain from this treatment, tai chi might be a gentle way to find relief.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07715188Recruiting
Low dose radiation for osteoarthritis
This trial tests if a very low dose of radiation can help relieve pain from osteoarthritis in joints like hips, knees, hands, shoulders, ankles, or elbows. It is for people whose pain has not improved with standard treatments or who want to try a gentler option before considering surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05629494RecruitingPhase 4
Ibuprofen vs PSA blood test for prostate evaluation
This trial studies whether an anti-inflammatory medicine (ibuprofen) changes prostate-specific antigen (PSA) blood test results to help decide on next diagnostic steps like MRI or biopsy. It may help people with an elevated PSA understand whether follow-up testing is more or less likely to be needed.
Hershey, PennsylvaniaAges 18–80 - NCT07665372Recruiting
Liver transplant from donors with HIV for people with HIV
This study tests whether giving people with HIV a liver from an HIV-positive donor is safe and works well. It looks at infections, cancer risks, and long-term health after transplant.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07663422RecruitingPhase 2
Treating immunotherapy-related liver inflammation with mycophenolate and prednisone
This trial tests a combination of two drugs, mycophenolate mofetil and prednisone, to treat moderate to severe liver inflammation caused by immunotherapy. The goal is to see if this treatment can help control the inflammation without needing long-term high-dose steroids.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05001477Recruiting
Registry for men receiving TULSA-PRO prostate treatment
This is a study registry that collects information from men who are going to receive TULSA-PRO treatment. It helps researchers understand how the treatment is used and what outcomes people experience.
York, PennsylvaniaAges 18 years+ - NCT07644585Recruiting
Ultra-High Dose Rate Radiation for Recurrent Head and Neck Cancer
This trial tests a new type of radiation therapy called ConformalFLASH that delivers radiation extremely quickly to treat head and neck cancer that has come back after previous radiation. It may help patients who cannot have surgery or have declined it.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07631650RecruitingPhase 2
Bevonescein to help surgeons see nerves during thyroid surgery
This study tests a special dye called bevonescein that helps surgeons see nerves better during thyroid removal surgery. The goal is to protect your voice by preventing nerve damage during the procedure.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07636174Enrolling by invitation
Text reminders to help you get colorectal cancer screening
This study tests whether text messages can help you remember and complete colorectal cancer screening tests like FIT or colonoscopy. You'll receive reminder texts before and after your doctor's visit to encourage you to get screened.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07615049RecruitingPhase 3
Shorter versus standard radiation for soft tissue sarcoma
This trial compares a shorter course of radiation therapy with the standard longer course for people with soft tissue sarcoma in an arm or leg. The goal is to see if the shorter course works just as well and may be more convenient.
Chadds Ford, PennsylvaniaAges 18 years+ - NCT03860883Recruiting
Comparing wider versus narrower surgery margins for stage II melanoma
This trial studies whether removing a slightly wider strip of skin around a melanoma improves outcomes compared with a narrower strip. It also uses a lymph node staging procedure to check spread and helps doctors fine-tune surgery for stage II melanoma.
Allentown, PennsylvaniaAges 18 years+ - NCT07554560Recruiting
Nutrition Support for Pancreatic Cancer Patients
This study tests a nutrition intervention for people with pancreatic cancer who are having trouble eating or absorbing nutrients. The goal is to help patients maintain strength and improve their quality of life during cancer treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06230185Recruiting
Blood test to monitor treatment response in triple-negative breast cancer
This trial is testing whether a blood test can track how well chemotherapy is working in people with early-stage triple-negative breast cancer. You would provide blood samples before and during treatment, and the results may help your doctor understand your response better.
York, PennsylvaniaAges 18 years+ - NCT07478848RecruitingPhase 1
Radiation, Vancomycin, and CAR-T for B-cell lymphoma
This trial tests whether giving radiation and an oral antibiotic (vancomycin) before CAR-T therapy helps treat B-cell lymphoma more effectively. It is for people who are already scheduled to receive CAR-T treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07455032RecruitingPhase 1
Neoadjuvant therapy combo for head and neck cancer
This trial tests a combination of two drugs (CADI-05 and pembrolizumab) before surgery for people with a certain type of head and neck cancer that hasn't spread. The goal is to see if this treatment can help shrink the tumor before it is removed.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07417488RecruitingPhase 1
Vaccine therapy for advanced colorectal and small bowel cancer
This trial tests a vaccine therapy for people with advanced colorectal or small bowel cancer that has spread or can't be removed. The vaccine targets a protein found on cancer cells to help your immune system fight the cancer.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07412002Recruiting
End-of-life care quality for children with cancer
This trial asks bereaved parents about the quality of care their child received in the last month of life. It aims to improve how hospitals support families when a child with cancer is dying.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07406633RecruitingPhase 2
KQB198 plus imatinib for advanced GIST
This trial tests a new drug called KQB198 combined with imatinib for people with advanced or metastatic gastrointestinal stromal tumor (GIST) that has a specific KIT or PDGFRA mutation. The goal is to see if this combination works better than imatinib alone as a first treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07405151RecruitingPhase 1/Phase 2
New drug for advanced esophageal cancer after other treatments
This trial tests a new drug called Ifinatamab Deruxtecan for people with advanced esophageal squamous cell carcinoma that has progressed after one or two prior treatments. It aims to see if the drug can shrink tumors or slow the disease.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06069570RecruitingPhase 1
Gamma delta T cells and low dose radiation for advanced lung or bone cancer
This trial tests a new type of immune cell called gamma delta T cells combined with low-dose radiation to treat people with advanced lung cancer or solid tumors that have spread to the bone. It is only for patients who have already tried standard treatments and either didn't get better or couldn't tolerate them.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07337590Recruiting
New device to monitor healing after colorectal cancer surgery
This trial tests a new system that monitors healing inside the body after surgery for colorectal cancer. It is designed to help doctors detect problems early and keep you safe.
Pittsburgh, PennsylvaniaAges 21 years+ - NCT07336134Recruiting
HPV self-test for cervical health
This study offers a way to screen for cervical cancer using an HPV self-test. It is designed for women who may not have had a recent Pap smear and are from certain minority groups.
Philadelphia, PennsylvaniaAges 25–65 - NCT07332507RecruitingPhase 1
Testing teclistamab for recurrent plasmablastic lymphoma
This trial tests a new drug called teclistamab for people with plasmablastic lymphoma that has come back or not responded to standard treatments. The goal is to see if teclistamab can shrink tumors and control the disease.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07326566RecruitingPhase 2
Silevertinib and chemo for a type of glioblastoma
This trial tests a new drug, silevertinib, combined with temozolomide (a chemotherapy) for people with a newly diagnosed glioblastoma that has certain genetic markers. It aims to see if this combination works better than standard treatment for tumors with these specific features.
Philadelphia, PennsylvaniaAges 18 years+
Cancer trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting cancer studies listed above.
- Fox Chase Cancer Center · 4 studies
- UPMC Hillman Cancer Center · 4 studies
- Sidney Kimmel Cancer Center at Thomas Jefferson University · 2 studies
- Thomas Jefferson University · 2 studies
- Abramson Cancer Center, University of Pennsylvania
- Allegheny Health Network
- Cancer Care Associates of York
- Children's Hospital of Philadelphia
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cancer trials in other states
Common questions
- Are there cancer clinical trials in Pennsylvania?
- Yes. We're currently tracking 831 recruiting cancer studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.