Clinical trials
Cardiovascular Disease Risk clinical trials
Below are recruiting cardiovascular disease risk clinical trials, each written for real people, not researchers. We’re tracking 367 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06961630RecruitingEarly Phase 1
Heart protection after surgery
This trial tests if a personalized approach with blood thinners and statins can reduce heart risks after non-cardiac surgery. It is for adults 45 and older who had a heart injury during or after surgery.
New York, New YorkAges 45 years+ - NCT06650488RecruitingPhase 4
Clopidogrel vs. Aspirin for Heart Protection in Blood Infection Patients
This trial tests whether switching from aspirin to clopidogrel better protects your heart and blood vessels during recovery from a serious staph infection in the blood. You may be eligible if you currently take aspirin for heart or stroke prevention.
Montreal, QuebecAges 18 years+ - NCT06784557RecruitingPhase 4
Study of ezetimibe's effect on gut bacteria
This trial tests whether ezetimibe, a cholesterol-lowering drug, changes the bacteria in your gut. It may help people with heart disease or high cholesterol who are already on a statin.
SeoulAges 19–80 - NCT06118281RecruitingPhase 3
Testing ziltivekimab after a heart attack
This study tests a new drug called ziltivekimab to see if it helps people who have recently had a heart attack. The drug is given as an injection and compared to a placebo (a shot with no active medicine).
Alexander City, AlabamaAges 18 years+ - NCT06517537Recruiting
Modified aortic root enlargement for small aortic valves
This trial tests a modified surgical technique for replacing a narrowed aortic valve in people whose valve opening is unusually small. The goal is to help the new valve fit better and work well.
Beijing, Beijing MunicipalityAges 50–70 - NCT07478887Recruiting
Corrie Lipids app for better cholesterol management
This study tests a smartphone app called Corrie Lipids to help people with high cholesterol get their LDL levels under control. It may be a good fit if you have high cholesterol that isn't well managed and you have heart disease risk factors like diabetes or a family history.
Baltimore, MarylandAges 18 years+ - NCT07517263RecruitingPhase 3
Long-term Safety Study of Pelacarsen Treatment
This study follows patients who completed an earlier pelacarsen trial to check if the treatment remains safe and well-tolerated over time. Pelacarsen is an experimental medicine being tested for heart and cholesterol health.
Andalusia, AlabamaAges 18–100 - NCT07532863Recruiting
Heart Health Study for Newly Diagnosed Type 2 Diabetes
This study looks at how newly diagnosed type 2 diabetes affects heart and blood vessel health. Researchers will follow patients over time to understand the relationship between diabetes and cardiovascular risk.
Tangerang, BantenAges 40–70 - NCT07113223Recruiting
AI heart test for heart failure detection in people over 65
This trial uses an artificial intelligence system to analyze electrocardiograms (ECGs, which are recordings of your heart's electrical activity) to detect heart failure early. It is for people over 65 who either have symptoms that might be heart failure or have risk factors for heart failure but no current symptoms.
MadridAges 65 years+ - NCT06397729Recruiting
Testing a new tool to support healthy habits in rural clinics
This study is testing a new way to help people improve their heart health by making healthy changes in their daily habits. It focuses on patients in rural primary care clinics who are at higher risk because of their weight.
St Louis, MissouriAges 18–64 - NCT07704164RecruitingPhase 2
Colchicine to lower heart artery swelling in HIV
This trial tests if colchicine, a medicine for inflammation, can reduce swelling in the heart arteries of people with HIV. It may help lower the risk of heart problems in those already on a statin or similar medication.
BarcelonaAges 50 years+ - NCT03264352RecruitingPhase 4
Treatment for slightly high blood pressure in type 2 diabetes
This trial tests an intervention to help adults with type 2 diabetes who have “high-normal” blood pressure (not severely high). If you qualify, you may learn whether this approach improves blood pressure and related health outcomes over time.
Guangzhou, GuangdongAges 45–79 - NCT03480633Recruiting
Heart failure precision medicine registry
This registry collects health and heart-related information to better understand heart failure (with preserved or reduced pumping strength) and guide more precise care. You may be asked to share tests and results, and help researchers learn which patterns match different types of heart failure.
Boston, MassachusettsAges 18 years+ - NCT07315997Recruiting
Heart health study for people with rheumatoid arthritis
This study looks at whether calcium in the heart arteries and a blood test (troponin) can help predict heart disease risk in people with rheumatoid arthritis. It may help doctors better prevent heart attacks and strokes.
Boston, MassachusettsAges 35–79 - NCT04444128Recruiting
Testing heart risk assessment using MRI T1 mapping
This study checks whether an MRI heart scan measure called “T1 mapping” can improve how doctors estimate heart disease risk in everyday people. You may join if you’re an adult and can have a contrast-enhanced heart MRI safely.
Frankfurt am Main, HesseAges 18 years+ - NCT04514445Recruiting
Study of genes in people with bicuspid aortic valve
This study looks for genetic (inherited) differences that may be linked to bicuspid aortic valve (BAV). It includes people with BAV and close family members to help understand why BAV happens and whether genes play a role.
KetteringAges 10–99 - NCT04686253Recruiting
Study how a heart opening and its flow link to stroke
This study looks at the detailed flow pattern through a patent foramen ovale (PFO)—a small opening in the heart—and how it may relate to stroke, TIA, or migraine. Doctors use special ultrasound testing with contrast to better understand who is most affected.
Beijing, Beijing MunicipalityAges 16–65 - NCT04725617Recruiting
Smoking-quit program for people with HIV and sleep issues
This study tests a wellness-based smoking-cessation program (including the stop-smoking medicine varenicline) for people living with HIV who want to quit. It aims to help you reduce or stop smoking while monitoring safety, sleep, and mental health during the program.
Phoenix, ArizonaAges 18–75 - NCT05257629RecruitingPhase 3
Aggressive smoking quit program after heart problems
This trial tests whether a strong quit plan using varenicline (a quit pill) plus nicotine e-cigarettes, along with counseling, helps people stop smoking after a recent heart-related event. It’s aimed at people who want to quit and can safely stay involved for about a year.
New Westminster, British ColumbiaAges 18 years+ - NCT05277233Recruiting
Cardiovascular risk check years after preeclampsia
This study looks at heart and blood-vessel risk long after a pregnancy complication called preeclampsia. It may help researchers understand who is at higher risk and how to monitor you more closely.
BerlinAges 18–60 - NCT05488431RecruitingPhase 2
Bempedoic acid to lower cholesterol and inflammation in HIV
This Phase 2 trial studies whether bempedoic acid can lower cholesterol and inflammation in people with HIV who are already on effective HIV medications. It may help reduce signs of artery inflammation that can contribute to heart and stroke risk.
Los Angeles, CaliforniaAges 40 years+ - NCT05739253Recruiting
Study how the aorta changes after a valve procedure
This trial looks at how the ascending aorta (the main artery near the heart) changes over time after transcatheter aortic valve replacement. It may help doctors predict who is at risk of aorta enlargement after this less-invasive valve procedure.
Beijing, Beijing MunicipalityAges Any age - NCT05841784Recruiting
Mindfulness coaching for stress and mood after heart risk
This study tests a structured mindfulness program (MBCT-T) to help people who have elevated stress and/or mild anxiety or depression in the setting of heart disease or heart risk factors. It may help improve emotional well-being and stress levels while you live with these health concerns.
New York, New YorkAges 18 years+ - NCT05919342Recruiting
Screening for early heart failure in primary care or at home
This trial tests whether simple screening using a blood test (natriuretic peptides) plus an ultrasound of the heart (echocardiogram) can find early heart failure sooner. Finding it earlier may help doctors start the right management to prevent it from getting worse.
Cleveland, OhioAges 40 years+
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Common questions
- Are there clinical trials for cardiovascular disease risk?
- Yes. Clin2 currently lists 367 recruiting cardiovascular disease risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cardiovascular disease risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cardiovascular disease risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.