Clinical trials · Illinois
Cardiovascular Diseases clinical trials in Illinois
We’re tracking 30 recruiting cardiovascular diseases studies with a site in Illinois — including Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Illinois
- NCT06907524Recruiting
Preventive health screening and coaching for food insecure adults
This study offers preventive health screening and coaching to people who may have food insecurity and risk factors for heart disease or diabetes. It aims to help you improve your health through education and support.
Chicago, IllinoisAges 40–75 - NCT07181109RecruitingPhase 3
Study of zilebesiran for high-risk hypertension patients
This trial tests a new medicine called zilebesiran for people with high blood pressure that isn't well controlled. It may be an option if you have heart or blood vessel disease, or are at high risk for it.
Arlington Heights, IllinoisAges 18 years+ - NCT03683186Enrolling by invitationPhase 3
Long-term study of ralinepag for pulmonary hypertension
This study follows people with pulmonary arterial hypertension (PAH) to see how safe and effective ralinepag is over the long term. It may help your care team understand what to expect from continued treatment and monitoring.
Elk Grove Village, IllinoisAges 18 years+ - NCT07037433RecruitingPhase 3
Heart protection study for people with heart disease and overweight
This study tests a new weekly injection (maridebart cafraglutide) to see if it helps lower the risk of heart problems in people with heart disease and overweight. It is for adults who have had a heart attack, stroke, or artery blockages and also have a BMI of 27 or higher.
Arlington Heights, IllinoisAges 45–99 - NCT03142152Recruiting
Mitral valve implant for heart failure with leaky mitral valve
This trial tests whether a device called the Carillon Mitral Contour System can help people with heart failure caused by a mild-to-moderate leaky mitral valve. You’d be compared against a control group, and the goal is to improve heart failure symptoms and outcomes.
Springfield, IllinoisAges 18 years+ - NCT07064473RecruitingPhase 3
Testing vicadrostat plus empagliflozin for diabetes, high blood pressure, and heart disease
This study tests a new pill called vicadrostat taken with another medicine (empagliflozin) to see if it helps people with type 2 diabetes, high blood pressure, and heart disease. It may reduce the risk of heart problems, but you must not have had heart failure or use certain other heart medications.
Chicago, IllinoisAges 18 years+ - NCT07420907Recruiting
Tracking heart health over time
This study uses a wearable patch to monitor heart-related signs in people with heart conditions. It aims to learn more about how these conditions progress, which could help improve future care.
Chicago, IllinoisAges 18 years+ - NCT06506942Recruiting
TRICURE device study for leaky heart valve
This study tests a new device to help people with severe tricuspid regurgitation (leaky heart valve) who are at higher risk from surgery. It aims to see if the device can reduce the leak and improve symptoms.
Chicago, IllinoisAges 18 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Oakbrook Terrace, IllinoisAges 18 years+ - NCT07136012RecruitingPhase 3
Olpasiran trial to lower Lp(a) and prevent first heart attack or stroke
This trial tests if olpasiran can lower a type of cholesterol called Lp(a) to help prevent a first major heart attack, stroke, or other heart problems. It is for people at higher risk due to risk factors or early signs of artery disease, but who have not yet had a heart attack or stroke.
Arlington Heights, IllinoisAges 50–105 - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Chicago, IllinoisAges 18–100 - NCT06297291Recruiting
Long-term safety study for a kidney nerve treatment
This study tests a device that uses ultrasound to calm overactive kidney nerves, which may help lower blood pressure. It is for people with high blood pressure that is hard to control with medication.
Springfield, IllinoisAges 18 years+ - NCT06511505Recruiting
Testing AI to find hidden heart conditions from ECGs
This study uses an AI tool to look at your ECG (a simple heart test) to help find early signs of atrial fibrillation (an irregular heartbeat) or structural heart disease (changes in heart structure). It aims to see if the AI can help doctors catch these conditions sooner, even in people who don't yet have symptoms.
Chicago, IllinoisAges 40 years+ - NCT06271590Recruiting
Drug-coated balloon for small heart artery blockages
This trial tests a special balloon coated with a drug (sirolimus) to treat blockages in small heart arteries. If the balloon is successful, it may help keep the artery open without needing a permanent stent.
Maywood, IllinoisAges 18–80 - NCT07157774RecruitingPhase 3
Muvalaplin for heart disease in people with high lipoprotein(a)
This study tests a new medicine called muvalaplin that lowers a specific type of cholesterol linked to heart disease. It aims to see if muvalaplin can reduce the risk of future heart attacks, strokes, or related procedures in people with high levels of this cholesterol.
Chicago, IllinoisAges 18 years+ - NCT07000357RecruitingPhase 3
Study of AZD0780 to reduce heart attack and stroke risk
This trial tests a new medication, AZD0780, to see if it helps prevent major cardiovascular events like heart attacks or strokes in people who already have heart or blood vessel disease, or are at high risk for a first event. It might be a good fit if your cholesterol isn't well-controlled despite current treatments.
Arlington Heights, IllinoisAges 18 years+ - NCT07517263RecruitingPhase 3
Long-term Safety Study of Pelacarsen Treatment
This study follows patients who completed an earlier pelacarsen trial to check if the treatment remains safe and well-tolerated over time. Pelacarsen is an experimental medicine being tested for heart and cholesterol health.
Chicago, IllinoisAges 18–100 - NCT04262206RecruitingPhase 4
Testing how statins affect outcomes in adults 75 and older
This trial studies whether cholesterol-lowering medicine (a statin, specifically atorvastatin) improves health and benefits in people age 75 and older in everyday life. It may help doctors understand which older adults benefit most and how to use these medicines safely.
Chicago, IllinoisAges 75 years+ - NCT04755153Recruiting
Community health program to lower heart disease risk
This trial tests a community-based health intervention in Chicago to help reduce the risk of cardiovascular (heart and blood vessel) disease. It may help people by offering structured support through local clinics or churches.
Chicago, IllinoisAges 18–89 - NCT05199454Recruiting
Study how “fat-like” particles affect blood vessel function
This study looks at whether tiny fat-based particles (“adiposomes”) can affect how well your blood vessels work, especially in people with diabetes and higher body weight. You may be asked to do moderate exercise and other study procedures after passing safety checks.
Chicago, IllinoisAges 18–50 - NCT06747806Recruiting
A heart surgery biobank study
This study collects tissue samples from children and adults having heart surgery. The samples will help researchers learn more about heart conditions and improve future treatments.
Hyde Park, IllinoisAges Any age - NCT06813911RecruitingPhase 3
Testing pelacarsen for high Lp(a) in heart disease patients
This trial tests a new medicine called pelacarsen for people with very high Lp(a) (a type of cholesterol) and existing heart or blood vessel disease. It aims to see if adding pelacarsen to your current cholesterol treatment can lower your Lp(a) levels further.
Park Ridge, IllinoisAges 18–80 - NCT06870591Recruiting
Heart measurement device study
This trial tests a new device that measures heart function without needing an invasive catheter. It aims to see if the device works as well as the standard right heart catheterization procedure.
Evanston, IllinoisAges 18 years+ - NCT06875973RecruitingPhase 3
Pelacarsen long-term extension study
This trial is for people who have already finished taking pelacarsen in a previous study. It offers continued access to the drug and checks long-term safety.
Chicago, IllinoisAges 18–100
Cardiovascular Diseases trials by city in Illinois
Where these studies are running in Illinois
Institutions with a site for the recruiting cardiovascular diseases studies listed above.
- University of Chicago · 5 studies
- Northwestern University · 4 studies
- Rush University Medical Center · 4 studies
- Advocate Lutheran General Hospital · 3 studies
- Accellacare - Duly Health and Care · 2 studies
- Northwest Community Hospital · 2 studies
- Prairie Education and Research Cooperative · 2 studies
- University of Illinois · 2 studies
What taking part in a cardiovascular diseases study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cardiovascular Diseases trials in other states
Common questions
- Are there cardiovascular diseases clinical trials in Illinois?
- Yes. We're currently tracking 30 recruiting cardiovascular diseases studies with a site in Illinois, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cardiovascular diseases study in Illinois?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Illinois to take part?
- Not necessarily. These studies have a site in Illinois, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cardiovascular diseases trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cardiovascular diseases studies open in Illinois regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.