Clinical trials · Pennsylvania
Cardiovascular Diseases clinical trials in Pennsylvania
We’re tracking 35 recruiting cardiovascular diseases studies with a site in Pennsylvania — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT07181109RecruitingPhase 3
Study of zilebesiran for high-risk hypertension patients
This trial tests a new medicine called zilebesiran for people with high blood pressure that isn't well controlled. It may be an option if you have heart or blood vessel disease, or are at high risk for it.
Camp Hill, PennsylvaniaAges 18 years+ - NCT03683186Enrolling by invitationPhase 3
Long-term study of ralinepag for pulmonary hypertension
This study follows people with pulmonary arterial hypertension (PAH) to see how safe and effective ralinepag is over the long term. It may help your care team understand what to expect from continued treatment and monitoring.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07037433RecruitingPhase 3
Heart protection study for people with heart disease and overweight
This study tests a new weekly injection (maridebart cafraglutide) to see if it helps lower the risk of heart problems in people with heart disease and overweight. It is for adults who have had a heart attack, stroke, or artery blockages and also have a BMI of 27 or higher.
Beaver, PennsylvaniaAges 45–99 - NCT06303869Recruiting
Deep brain stimulation for speech after stroke
This study tests if deep brain stimulation (a small device implanted in the brain) can improve speech and arm movement after a stroke that affected the deeper parts of the brain. It is designed for people who have trouble speaking clearly (dysarthria) from their stroke.
Pittsburgh, PennsylvaniaAges 18–75 - NCT04286516Recruiting
Brain and robot training for arm movement after stroke
This study tests whether brain stimulation and robotic/arm training can improve arm movement in people who had a stroke. It may help strengthen movement and coordination by targeting brain pathways related to arm control.
Pittsburgh, PennsylvaniaAges 45–90 - NCT03142152Recruiting
Mitral valve implant for heart failure with leaky mitral valve
This trial tests whether a device called the Carillon Mitral Contour System can help people with heart failure caused by a mild-to-moderate leaky mitral valve. You’d be compared against a control group, and the goal is to improve heart failure symptoms and outcomes.
Lancaster, PennsylvaniaAges 18 years+ - NCT07064473RecruitingPhase 3
Testing vicadrostat plus empagliflozin for diabetes, high blood pressure, and heart disease
This study tests a new pill called vicadrostat taken with another medicine (empagliflozin) to see if it helps people with type 2 diabetes, high blood pressure, and heart disease. It may reduce the risk of heart problems, but you must not have had heart failure or use certain other heart medications.
Beaver, PennsylvaniaAges 18 years+ - NCT06542432Enrolling by invitation
Genetic risk test for heart disease prevention
This trial uses a polygenic risk score to see if knowing your genetic risk for coronary artery disease can help prevent a first heart attack. If you have an intermediate 10-year risk and no prior heart events, you may be eligible.
Philadelphia, PennsylvaniaAges 40–70 - NCT07214376Recruiting
Nerve ablation for pulmonary hypertension from left heart disease
This trial tests a device that uses a catheter to deliver energy to nerves around the pulmonary arteries, aiming to reduce high blood pressure in the lungs caused by left heart failure. It is for people with ongoing heart failure symptoms despite optimal medications.
Mechanicsburg, PennsylvaniaAges 18–85 - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Hershey, PennsylvaniaAges 18 years+ - NCT07518719Recruiting
Nutrition and kidney health support program for chronic kidney disease
This study tests a program that combines nutrition guidance and kidney health support to help people with chronic kidney disease manage their condition. You may join if you have kidney disease plus diabetes, high blood pressure, overweight, or food insecurity, and you are willing to make healthy changes.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07136012RecruitingPhase 3
Olpasiran trial to lower Lp(a) and prevent first heart attack or stroke
This trial tests if olpasiran can lower a type of cholesterol called Lp(a) to help prevent a first major heart attack, stroke, or other heart problems. It is for people at higher risk due to risk factors or early signs of artery disease, but who have not yet had a heart attack or stroke.
Pittsburgh, PennsylvaniaAges 50–105 - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Philadelphia, PennsylvaniaAges 18–100 - NCT06297291Recruiting
Long-term safety study for a kidney nerve treatment
This study tests a device that uses ultrasound to calm overactive kidney nerves, which may help lower blood pressure. It is for people with high blood pressure that is hard to control with medication.
Phildelphia, PennsylvaniaAges 18 years+ - NCT07783802RecruitingPhase 2
Study of clazakizumab for adults with high inflammation and heart risk
This study tests whether clazakizumab can reduce the risk of heart attacks or strokes in people with high levels of inflammation (measured by a blood test called hsCRP) and conditions like heart disease, obesity, diabetes, high blood pressure, or kidney disease. If you qualify, you'll receive either the study drug or a placebo to see if it helps lower your risk.
West Chester, PennsylvaniaAges 18 years+ - NCT06271590Recruiting
Drug-coated balloon for small heart artery blockages
This trial tests a special balloon coated with a drug (sirolimus) to treat blockages in small heart arteries. If the balloon is successful, it may help keep the artery open without needing a permanent stent.
Pittsburgh, PennsylvaniaAges 18–80 - NCT06281665RecruitingPhase 4
Aspirin after preeclampsia: the TAP trial
This trial tests whether taking low-dose aspirin after giving birth can help people who had preeclampsia. It aims to see if aspirin can lower the risk of future heart problems.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07293260RecruitingPhase 3
Olpasiran heart scan study for high Lp(a) patients
This study tests if a medication called olpasiran can lower a type of fat in your blood called Lp(a), which is linked to heart problems. You take the medicine or a placebo and get a special heart scan to see changes in your arteries.
Philadelphia, PennsylvaniaAges 35–80 - NCT07157774RecruitingPhase 3
Muvalaplin for heart disease in people with high lipoprotein(a)
This study tests a new medicine called muvalaplin that lowers a specific type of cholesterol linked to heart disease. It aims to see if muvalaplin can reduce the risk of future heart attacks, strokes, or related procedures in people with high levels of this cholesterol.
Allentown, PennsylvaniaAges 18 years+ - NCT06870591Recruiting
Heart measurement device study
This trial tests a new device that measures heart function without needing an invasive catheter. It aims to see if the device works as well as the standard right heart catheterization procedure.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07000357RecruitingPhase 3
Study of AZD0780 to reduce heart attack and stroke risk
This trial tests a new medication, AZD0780, to see if it helps prevent major cardiovascular events like heart attacks or strokes in people who already have heart or blood vessel disease, or are at high risk for a first event. It might be a good fit if your cholesterol isn't well-controlled despite current treatments.
Camp Hill, PennsylvaniaAges 18 years+ - NCT06732102Recruiting
Philly Heart Health Study: DECIDE+
This study tests a program to help Philadelphians with conditions like high blood pressure, diabetes, or weight concerns and unmet social needs (like food or housing) get better health support. You'll work with a community health worker to learn ways to improve your health.
Philadelphia, PennsylvaniaAges 35–75 - NCT06244199Recruiting
Transition to cardiac rehabilitation for veterans with heart disease
This study tests a program that helps Veterans with heart disease start cardiac rehabilitation (a supervised exercise and education program to improve heart health) while they are still in the hospital. It aims to overcome barriers like other health problems and frailty, and may add up to 2 days to your hospital stay.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06216678Recruiting
Can healthy diets with plant oils improve heart health?
This study tests if adding plant oils to a healthy diet can improve cholesterol and other heart health markers in people with moderately high cholesterol. It involves following a specific meal plan and having your health monitored over several weeks.
University Park, PennsylvaniaAges 25–60
Cardiovascular Diseases trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting cardiovascular diseases studies listed above.
- University of Pennsylvania · 6 studies
- Allegheny Health Network · 3 studies
- Capital Area Research, LLC · 3 studies
- Abington Medical Specialists · 2 studies
- Cardiology Consultants of Philadelphia Yardley · 2 studies
- Heritage Valley Health System · 2 studies
- Suburban Research Associates · 2 studies
- Thomas Jefferson University · 2 studies
What taking part in a cardiovascular diseases study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cardiovascular Diseases trials in other states
Common questions
- Are there cardiovascular diseases clinical trials in Pennsylvania?
- Yes. We're currently tracking 35 recruiting cardiovascular diseases studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cardiovascular diseases study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cardiovascular diseases trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cardiovascular diseases studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.