Clinical trials · Massachusetts
Cardiovascular Diseases clinical trials in Massachusetts
We’re tracking 40 recruiting cardiovascular diseases studies with a site in Massachusetts — including Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT07260032Recruiting
Exercise study for PTSD and heart health
This study tests if a supervised exercise program can improve heart health in people with PTSD. It may help reduce your risk of heart disease.
Boston, MassachusettsAges 18–65 - NCT04895995Recruiting
Digital CBT program for anxiety after heart or stroke events
This trial tests a scalable online “CBT” program (a structured talking-therapy approach) to reduce generalized anxiety and related health behaviors in people after a recent heart or stroke problem. If you qualify, it may help you learn tools to manage anxiety and health routines in a convenient digital format.
Boston, MassachusettsAges 18 years+ - NCT03683186Enrolling by invitationPhase 3
Long-term study of ralinepag for pulmonary hypertension
This study follows people with pulmonary arterial hypertension (PAH) to see how safe and effective ralinepag is over the long term. It may help your care team understand what to expect from continued treatment and monitoring.
Boston, MassachusettsAges 18 years+ - NCT07037433RecruitingPhase 3
Heart protection study for people with heart disease and overweight
This study tests a new weekly injection (maridebart cafraglutide) to see if it helps lower the risk of heart problems in people with heart disease and overweight. It is for adults who have had a heart attack, stroke, or artery blockages and also have a BMI of 27 or higher.
New Bedford, MassachusettsAges 45–99 - NCT06644742Recruiting
PKP2 heart condition natural history study
This study is for people with a specific genetic heart condition (PKP2-related arrhythmogenic cardiomyopathy) who already have an ICD. It does not test a new treatment but instead follows participants over time to learn more about the condition.
Boston, MassachusettsAges 12 years+ - NCT06907147Recruiting
Renal denervation for uncontrolled high blood pressure
This trial tests a procedure called renal denervation to lower blood pressure in people whose medication isn't enough. It uses a special catheter to calm nerves near the kidneys that may be overactive.
Boston, MassachusettsAges 18–80 - NCT03142152Recruiting
Mitral valve implant for heart failure with leaky mitral valve
This trial tests whether a device called the Carillon Mitral Contour System can help people with heart failure caused by a mild-to-moderate leaky mitral valve. You’d be compared against a control group, and the goal is to improve heart failure symptoms and outcomes.
Boston, MassachusettsAges 18 years+ - NCT07064473RecruitingPhase 3
Testing vicadrostat plus empagliflozin for diabetes, high blood pressure, and heart disease
This study tests a new pill called vicadrostat taken with another medicine (empagliflozin) to see if it helps people with type 2 diabetes, high blood pressure, and heart disease. It may reduce the risk of heart problems, but you must not have had heart failure or use certain other heart medications.
Malden, MassachusettsAges 18 years+ - NCT05169333Recruiting
Oxford study using non-invasive imaging to learn risk factors
This study looks at factors that can predict health risks and uses non-invasive imaging (no major procedures) to collect information. It may help researchers better understand who is at higher risk over time and why.
Boston, MassachusettsAges 18–99 - NCT06408961Recruiting
EVs in Obesity and Cardiometabolic Disease
This study looks at tiny particles released by cells (called extracellular vesicles, or EVs) in people with obesity and related heart health issues. Researchers want to see if these particles are different in people with obesity and diabetes, which could help find new ways to treat or prevent heart problems.
Boston, MassachusettsAges 18 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Boston, MassachusettsAges 18 years+ - NCT07136012RecruitingPhase 3
Olpasiran trial to lower Lp(a) and prevent first heart attack or stroke
This trial tests if olpasiran can lower a type of cholesterol called Lp(a) to help prevent a first major heart attack, stroke, or other heart problems. It is for people at higher risk due to risk factors or early signs of artery disease, but who have not yet had a heart attack or stroke.
Boston, MassachusettsAges 50–105 - NCT07286578Recruiting
Using heart CT scans to guide treatment for blocked arteries
This trial is testing whether a special heart CT scan (coronary CT angiography) can help doctors better understand and treat calcium buildup in your heart arteries. If you have a type of heart disease that might need a stent or other procedure, this study could help decide the best approach.
Boston, MassachusettsAges 18–85 - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Boston, MassachusettsAges 18–100 - NCT06297291Recruiting
Long-term safety study for a kidney nerve treatment
This study tests a device that uses ultrasound to calm overactive kidney nerves, which may help lower blood pressure. It is for people with high blood pressure that is hard to control with medication.
Boston, MassachusettsAges 18 years+ - NCT07148817Recruiting
Do earplugs help with noise-related heart disease?
This study tests if wearing earplugs at night can lower the negative effects of traffic noise on your heart health. It looks for people who are bothered by noise or live in a noisy area and have heart disease or risk factors like high blood pressure.
Boston, MassachusettsAges 18–65 - NCT07174622Recruiting
Long-term results for renal denervation study
This study tracks patients who have uncontrolled high blood pressure and are on a steady medication plan. It checks how kidney nerve treatment (renal denervation) works in real life over time.
Boston, MassachusettsAges 18 years+ - NCT06374498Enrolling by invitation
Looking inside heart arteries to improve stent placement
This study tests a new imaging technique to help doctors see inside your heart arteries during a stent procedure. It may help guide treatment and improve outcomes for people with heart disease.
Boston, MassachusettsAges 18 years+ - NCT05908331Recruiting
Balloon treatment test for narrowed stents in heart arteries
This trial tests whether a special drug-coated balloon (“MagicTouch”) can treat re-narrowing inside a previously placed stent. It may help patients whose stent has become blocked again, by improving blood flow and reducing repeat narrowing.
Boston, MassachusettsAges 18–110 - NCT06235112Recruiting
AI Screening for Heart Calcium from Chest CT Scans
This research study uses an artificial intelligence program to screen old chest CT scans for calcium buildup in the heart arteries. If you are between 40 and 75 and have had a chest CT in the last 3 years, this may help identify if you are at risk for heart disease so you can take steps to prevent it.
Boston, MassachusettsAges 40–75 - NCT06202820Recruiting
Heart health monitoring for men on hormone therapy
This study checks how men starting hormone therapy (ADT) for prostate cancer are doing with their heart health. It offers follow-up visits at the cancer center to track blood pressure and lab results, with the goal of catching any heart-related issues early.
Boston, MassachusettsAges 18 years+ - NCT07087431Recruiting
Genetic risk score for heart disease and health habits
This study looks at whether sharing a genetic risk score for heart disease can help people make heart-healthy changes. If you're not on cholesterol medication, you may be able to join.
Boston, MassachusettsAges 30–75 - NCT06001814Recruiting
Mindfulness program for heart health in older adults with HIV
This study tests whether a mindfulness and behavior change program can help older adults with HIV improve their heart health. It combines phone-based coaching and text messages to reduce stress and manage heart risk factors like high blood pressure and diabetes.
Boston, MassachusettsAges 50 years+ - NCT07157774RecruitingPhase 3
Muvalaplin for heart disease in people with high lipoprotein(a)
This study tests a new medicine called muvalaplin that lowers a specific type of cholesterol linked to heart disease. It aims to see if muvalaplin can reduce the risk of future heart attacks, strokes, or related procedures in people with high levels of this cholesterol.
Boston, MassachusettsAges 18 years+
Cardiovascular Diseases trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting cardiovascular diseases studies listed above.
- Massachusetts General Hospital · 11 studies
- Brigham and Women's Hospital · 7 studies
- Beth Israel Deaconess Medical Center · 4 studies
- Tufts Medical Center · 2 studies
- ActivMed Practices and Research
- Boston Children's Hospital
- Boston University
- Boston University Medical Center
What taking part in a cardiovascular diseases study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cardiovascular Diseases trials in other states
Common questions
- Are there cardiovascular diseases clinical trials in Massachusetts?
- Yes. We're currently tracking 40 recruiting cardiovascular diseases studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cardiovascular diseases study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cardiovascular diseases trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cardiovascular diseases studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.