Clinical trials · Minnesota
Cardiovascular Diseases clinical trials in Minnesota
We’re tracking 29 recruiting cardiovascular diseases studies with a site in Minnesota — including Early Phase 1, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Minnesota
- NCT07181109RecruitingPhase 3
Study of zilebesiran for high-risk hypertension patients
This trial tests a new medicine called zilebesiran for people with high blood pressure that isn't well controlled. It may be an option if you have heart or blood vessel disease, or are at high risk for it.
Richfield, MinnesotaAges 18 years+ - NCT06053645Recruiting
Weight and heart disease study
This study looks at how being overweight affects heart health. It tests a program that includes monthly check-ins and surveys, and is for people with a BMI of 30 or higher who also have a heart condition. The goal is to learn more about how to help people with both weight and heart concerns.
Rochester, MinnesotaAges 18 years+ - NCT07037433RecruitingPhase 3
Heart protection study for people with heart disease and overweight
This study tests a new weekly injection (maridebart cafraglutide) to see if it helps lower the risk of heart problems in people with heart disease and overweight. It is for adults who have had a heart attack, stroke, or artery blockages and also have a BMI of 27 or higher.
Maplewood, MinnesotaAges 45–99 - NCT06271577Recruiting
Smartphone ECG for heart attack detection
This study tests whether a smartphone can take a 12-lead ECG (a heart tracing) quickly when someone arrives at the ER with chest pain, to help doctors spot a heart attack sooner.
Rochester, MinnesotaAges 18 years+ - NCT03142152Recruiting
Mitral valve implant for heart failure with leaky mitral valve
This trial tests whether a device called the Carillon Mitral Contour System can help people with heart failure caused by a mild-to-moderate leaky mitral valve. You’d be compared against a control group, and the goal is to improve heart failure symptoms and outcomes.
Saint Cloud, MinnesotaAges 18 years+ - NCT07516444Recruiting
Tricuspid valve replacement using a new catheter device
This trial tests a new device that replaces a leaky tricuspid valve (a heart valve) without open-heart surgery. If your tricuspid valve isn't working well and medicines haven't helped enough, this procedure might improve your heart function and symptoms.
Minneapolis, MinnesotaAges 18 years+ - NCT06542432Enrolling by invitation
Genetic risk test for heart disease prevention
This trial uses a polygenic risk score to see if knowing your genetic risk for coronary artery disease can help prevent a first heart attack. If you have an intermediate 10-year risk and no prior heart events, you may be eligible.
Rochester, MinnesotaAges 40–70 - NCT03049254Recruiting
Registry and blood/tissue study for certain sudden heart death causes
This study builds a registry and collection of samples to better understand families affected by sudden heart death and related heart rhythm problems that are not clearly caused by a heart attack. It may help researchers identify patterns and improve future care, and it offers a way for patients and families to contribute to research.
Rochester, MinnesotaAges Any age - NCT06506942Recruiting
TRICURE device study for leaky heart valve
This study tests a new device to help people with severe tricuspid regurgitation (leaky heart valve) who are at higher risk from surgery. It aims to see if the device can reduce the leak and improve symptoms.
Minneapolis, MinnesotaAges 18 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Minneapolis, MinnesotaAges 18 years+ - NCT07136012RecruitingPhase 3
Olpasiran trial to lower Lp(a) and prevent first heart attack or stroke
This trial tests if olpasiran can lower a type of cholesterol called Lp(a) to help prevent a first major heart attack, stroke, or other heart problems. It is for people at higher risk due to risk factors or early signs of artery disease, but who have not yet had a heart attack or stroke.
Duluth, MinnesotaAges 50–105 - NCT07286578Recruiting
Using heart CT scans to guide treatment for blocked arteries
This trial is testing whether a special heart CT scan (coronary CT angiography) can help doctors better understand and treat calcium buildup in your heart arteries. If you have a type of heart disease that might need a stent or other procedure, this study could help decide the best approach.
Minneapolis, MinnesotaAges 18–85 - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Minneapolis, MinnesotaAges 18–100 - NCT06297291Recruiting
Long-term safety study for a kidney nerve treatment
This study tests a device that uses ultrasound to calm overactive kidney nerves, which may help lower blood pressure. It is for people with high blood pressure that is hard to control with medication.
Coon Rapids, MinnesotaAges 18 years+ - NCT05908331Recruiting
Balloon treatment test for narrowed stents in heart arteries
This trial tests whether a special drug-coated balloon (“MagicTouch”) can treat re-narrowing inside a previously placed stent. It may help patients whose stent has become blocked again, by improving blood flow and reducing repeat narrowing.
Coon Rapids, MinnesotaAges 18–110 - NCT07000357RecruitingPhase 3
Study of AZD0780 to reduce heart attack and stroke risk
This trial tests a new medication, AZD0780, to see if it helps prevent major cardiovascular events like heart attacks or strokes in people who already have heart or blood vessel disease, or are at high risk for a first event. It might be a good fit if your cholesterol isn't well-controlled despite current treatments.
Duluth, MinnesotaAges 18 years+ - NCT06826755Recruiting
Melatonin for heart health in midlife women
This study tests whether melatonin can help improve heart health in midlife women with high blood pressure. It involves taking a melatonin pill or placebo for several weeks and checking blood pressure and other health markers.
Rochester, MinnesotaAges 40–55 - NCT07517263RecruitingPhase 3
Long-term Safety Study of Pelacarsen Treatment
This study follows patients who completed an earlier pelacarsen trial to check if the treatment remains safe and well-tolerated over time. Pelacarsen is an experimental medicine being tested for heart and cholesterol health.
Maplewood, MinnesotaAges 18–100 - NCT04262206RecruitingPhase 4
Testing how statins affect outcomes in adults 75 and older
This trial studies whether cholesterol-lowering medicine (a statin, specifically atorvastatin) improves health and benefits in people age 75 and older in everyday life. It may help doctors understand which older adults benefit most and how to use these medicines safely.
Minneapolis, MinnesotaAges 75 years+ - NCT04521699Recruiting
CalmiGo stress device to improve heart blood vessel health
This study looks at whether a stress-management device (CalmiGo) can improve blood vessel function and heart disease risk in people recovering from recent heart procedures. You would use the device for 12 weeks and complete questionnaires, blood tests, and a heart-vessel test at the start and end.
Rochester, MinnesotaAges 18 years+ - NCT06187077Recruiting
Techquity by FAITH study for African Americans
This study tests a smartphone app to help African American adults live healthier. It looks at how digital health tools can improve fruits and vegetables intake and physical activity.
Rochester, MinnesotaAges 18 years+ - NCT06507657RecruitingEarly Phase 1
Empagliflozin for heart health in older adults
This study tests whether a medication called empagliflozin (a diabetes drug) can improve heart function in older adults with high blood pressure and obesity who are at risk for heart failure but do not have it yet. You would take the pill daily and have heart ultrasounds to check your heart's health.
Minneapolis, MinnesotaAges 60 years+ - NCT07224685Recruiting
Mayo heart & voice health study with phone and watch
This study uses your iPhone and Apple Watch to collect heart and voice data to learn more about cardiovascular health. It may help improve how doctors monitor heart conditions.
Rochester, MinnesotaAges 18 years+ - NCT07311044Recruiting
Heart health and voice study at Mayo Clinic
This study at Mayo Clinic looks at how heart and lung blood pressure (cardiovascular/pulmonary hypertension) might relate to voice characteristics. Researchers will use voice recordings from people having routine echocardiograms to see if voice changes can help detect heart problems earlier.
Rochester, MinnesotaAges 18 years+
Cardiovascular Diseases trials by city in Minnesota
Where these studies are running in Minnesota
Institutions with a site for the recruiting cardiovascular diseases studies listed above.
- Mayo Clinic · 12 studies
- Minneapolis Heart Institute · 7 studies
- University of Minnesota · 4 studies
- Metropolitan Heart and Vascular Institute · 2 studies
- Saint John's Hospital - Healtheast · 2 studies
- Abbott-Northwestern Hospital
- Allina Health Cancer Institute
- CentraCare Heart and Vascular Center
What taking part in a cardiovascular diseases study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cardiovascular Diseases trials in other states
Common questions
- Are there cardiovascular diseases clinical trials in Minnesota?
- Yes. We're currently tracking 29 recruiting cardiovascular diseases studies with a site in Minnesota, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cardiovascular diseases study in Minnesota?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Minnesota to take part?
- Not necessarily. These studies have a site in Minnesota, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cardiovascular diseases trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cardiovascular diseases studies open in Minnesota regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.