Cervical Neoplasms clinical trials

Simple blood, urine, and saliva test to find cancer early

This study tests a new way to find cancer by looking at DNA in blood, urine, and saliva. It may help detect cancer earlier and monitor how well treatment works.

Reminder and self-sampling to help cervical screening

This study tests whether reminders and providing an at-home sample kit can help more women complete cervical cancer screening. It may help people who have not had follow-up after a prior abnormal result or who haven’t been screened in many years.

Study of tiny cancer spread found in sentinel lymph nodes

This trial studies whether very small deposits of cancer (called micrometastasis or isolated tumor cells) are found in sentinel lymph nodes in early endometrial or cervical cancer. The goal is to better understand what these findings may mean for cancer spread and treatment planning.

Combination targeted drug and immunotherapy for recurrent gynecologic cancers

This trial tests a combination of two new drugs—becotatug vedotin (targeted therapy) and zimberelimab (immunotherapy)—in people with recurrent or metastatic cervical, vulvar, or vaginal cancer. The goal is to see if this combination works after standard treatments like platinum chemotherapy and immunotherapy have been tried.

Study of dostarlimab and bevacizumab for recurrent clear cell cancer

This trial tests a drug called dostarlimab alone or with bevacizumab compared to standard chemotherapy for women whose clear cell cancer of the ovary, uterus, cervix, vagina, or vulva has come back within a year of platinum chemotherapy. The goal is to see if these newer treatments can help control the cancer better.

Early trial for advanced cancers using HTL0039732

This is a Phase 1/2 study testing how well HTL0039732 works and is tolerated in people with advanced solid tumors that have not responded to standard treatments. It may help by offering a new treatment option and learning which cancer types and body markers respond best.

Study of UCB4594 for advanced cancers with HLA-G marker

This trial tests an experimental drug called UCB4594 for people with certain advanced cancers that have not responded to standard treatments. The goal is to see if the drug is safe and effective against tumors that have a specific marker called HLA-G.

Gene therapy follow-up for adults previously treated at NCI

This study is a follow-up check for people who were previously enrolled in certain NCI gene therapy treatment studies. It helps the research team monitor long-term effects and outcomes after treatment.

Sigvotatug vedotin for advanced solid tumors that spread

This early-stage study tests a drug called sigvotatug vedotin in people with advanced solid cancers that cannot be removed or have spread. It aims to see how well the treatment works and what side effects it causes.

Study of LY4170156 for advanced solid tumors

This study tests a new drug called LY4170156 for people with certain advanced solid tumors. It aims to see if the drug is safe and how well it works.

Can MRI scans help predict chemo-radiation success in cervical cancer?

This trial uses MRI scans taken before treatment to see if they can predict how well chemo-radiation will work for locally advanced cervical cancer. It aims to help doctors know which patients might benefit most from this therapy.

A Simple, Lab-Free Test for Cervical Cancer

This trial is testing a new, low-cost, lab-free screening test for cervical cancer. The goal is to see if it can detect early signs of cancer without needing a doctor's visit or a lab — making it easier for women to get screened.

Adaptive proton therapy for cervical cancer with chemo

This trial tests whether an “adaptive” type of radiation planning using proton therapy and MRI-guided brachytherapy can improve treatment for people with cervical cancer. It aims to deliver curative treatment more precisely while still combining it with chemotherapy (cisplatin) when appropriate.

New cervical cancer screening test using self-samples

This study is testing a new way to screen for cervical cancer using a sample you collect yourself. It aims to find a simpler, more accurate method that could replace more invasive tests.

Extra chemo after surgery for advanced cervical cancer

This Phase 3 trial tests whether adding chemotherapy after surgery helps people with locally advanced cervical cancer, especially when prior treatment didn’t fully match standard guidelines. It looks at whether this “adjuvant” chemotherapy improves outcomes after neoadjuvant chemotherapy and an extensive hysterectomy.

Reviewing outcomes after brachytherapy for women’s cancers

This study looks back at medical records to understand results after brachytherapy (a form of cancer radiation delivered from inside or close to the tumor) in women with gynecologic cancer. It may help doctors improve future treatment decisions, but you would not have to receive an experimental treatment.

Protein study of cervical neuroendocrine tumors

This study looks at the proteins in cervical neuroendocrine tumors to understand how they behave and how they affect long-term outcomes. It aims to find new markers that could help predict prognosis and guide treatment.

Prevent leg swelling after gynecologic cancer treatment

This study tests an early approach to help prevent lower-limb lymphedema (chronic leg swelling) after lymph node surgery and radiotherapy for gynecologic cancer. If you’re at risk, it may help your legs stay less swollen and reduce complications.

Radiation boost for cervical cancer: SABR vs brachytherapy

This trial compares two types of radiation boost therapy for locally advanced cervical cancer: a newer, precise type called SABR versus the standard brachytherapy. The goal is to see if SABR works as well or better with fewer side effects.

An Exploratory Study on the Efficacy and Safety of Enlonstobart Combined With Concurrent Radiotherapy and Chemotherapy Following Induction Therapy With Enlonstobart Plus Chemotherapy in Patients With Locally Advanced Cervical Cancer.

MRI-guided radiation plus chemo for cervical cancer

This trial tests a more precise way to deliver radiation for locally advanced cervical cancer using MRI guidance during treatment, along with chemotherapy. It may help shrink tumors more effectively while aiming to reduce side effects by targeting the right areas.

Immunotherapy and carbon ion radiation for advanced cervical cancer

This trial tests a new treatment that combines immunotherapy (drugs that help your immune system fight cancer) with carbon ion radiation (a precise type of radiation) for people with locally advanced cervical cancer that hasn't spread to other organs. The goal is to see if this combination is safe and effective.

Nivolumab plus ipilimumab with chemoradiation for cervical cancer

This Phase 2 study tests whether adding immunotherapy (nivolumab and ipilimumab) to standard chemoradiation can improve treatment for cervical cancer. It may help by training the immune system to better target cancer cells while radiation and chemotherapy work in the body.

Chemo plus radiation, then extra chemo for advanced cervical cancer

This Phase 3 study looks at whether adding chemotherapy after standard chemo-radiation can improve outcomes for advanced cervical cancer. You might be eligible if your cancer responded fully to initial treatment and you meet safety and health requirements.