Clinical trials
Chronic Knee Pain clinical trials
Below are recruiting chronic knee pain clinical trials, each written for real people, not researchers. We’re tracking 135 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07853170Recruiting
Comparing 3 vs 5-needle knee nerve blocks for arthritis pain
This study compares two ways of numbing the nerves around the knee to see which gives better pain relief and improves quality of life for people with knee osteoarthritis. It might help you decide if a nerve block is a good option for your knee pain.
Tanta, El-GharbiaAges 18 years+ - NCT06656156Recruiting
Stretching technique for chronic low back pain relief
This trial tests a physical therapy stretching method called PNF on the hip and hamstring muscles to see if it reduces chronic low back pain. It may help if you have had non-specific low back pain for over 3 months with tightness in your hips or legs.
Karachi, SindhAges 15–40 - NCT07426562Recruiting
Stretching vs. Dry Needling for Tight Hamstrings in Chronic Back Pain
This trial tests two treatments for tight hamstrings in people with long-lasting low back pain: a special stretch and dry needling (thin needles placed in trigger points). It aims to find which helps reduce tightness and pain.
Peshawar, Khyber PakhtunkhwaAges 20–50 - NCT07122453RecruitingPhase 1
Study of CNTX-3001 for severe chronic low back pain
This trial tests a medicine called CNTX-3001, given as a spinal injection, for people with long-term, severe low back pain that hasn't improved with other treatments.
Napa, CaliforniaAges 18–75 - NCT06221709Recruiting
Radiofrequency for hip arthritis pain: a clinical trial
This trial tests whether a treatment called continuous radiofrequency can reduce pain from hip arthritis. It is for people with moderate arthritis in one hip who have had pain for more than six months.
Brasília, Federal DistrictAges 18 years+ - NCT07347028Recruiting
Trigger point injections for knee osteoarthritis pain
This trial tests whether injecting medication into muscle knots (trigger points) can reduce knee pain in people with knee osteoarthritis. It may be an option if other treatments haven't helped enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT06859164RecruitingPhase 2
Knee artery treatment for chronic osteoarthritis pain
This trial tests a procedure called genicular artery embolization to reduce pain in people with knee osteoarthritis that hasn't improved with other treatments. The goal is to see if blocking certain blood vessels can relieve pain and help you avoid or delay knee replacement surgery.
Chicago, IllinoisAges 40–80 - NCT06430918Enrolling by invitation
Nerve pain and sleep quality in knee osteoarthritis
This study looks at how nerve pain and sleep quality are related in people with knee osteoarthritis. It aims to help doctors better understand and treat pain.
IzmirAges 18–80 - NCT07339137Recruiting
PRP injections for chronic knee osteoarthritis
This trial tests if platelet-rich plasma (PRP) injections into and around the knee joint can reduce pain and improve function for people with moderate knee osteoarthritis who haven't gotten relief from other treatments.
Ankara, ÇankayaAges 40–65 - NCT06863636RecruitingPhase 3
Combination painkiller vs celecoxib for osteoarthritis flare-ups
This study tests whether a combination of two pain relievers (celecoxib and acetaminophen) works better than celecoxib alone for sudden, severe osteoarthritis pain in the knee or hip.
Mexico CityAges 40 years+ - NCT06509087Recruiting
Combining CT and MRI for joint pain procedure
This study tests a procedure called transarterial microembolization for chronic shoulder or knee pain that hasn't improved with other treatments. It uses both CT and MRI to guide the procedure and see if it can help reduce pain.
TaipeiAges 20–80 - NCT07442435Recruiting
Reiki for recovery after knee replacement surgery
This study tests whether adding Reiki (a gentle hands-on relaxation therapy) to standard care helps people feel better and recover more comfortably after a first-time knee replacement. It may be a good fit if you are having your first knee replacement, are not on certain medications, and haven't tried energy therapies before.
SinopAges 18 years+ - NCT07134699Recruiting
Back pain's effect on thinking in older adults
This study looks at how long-term lower back pain affects thinking skills like memory and attention in adults aged 60 to 85. Participants must speak Cantonese, be right-handed, and have normal thinking abilities. The study uses email or text for some tasks.
Hong KongAges 60–85 - NCT07217821Recruiting
Music and imagery for chronic pain
This study tests a step-by-step approach using music and guided imagery to help people with long-term muscle or joint pain. It's done from home using a device, so you don't need to travel.
Indianapolis, IndianaAges 18 years+ - NCT07191067Recruiting
Study of NOVABLOC system for knee replacement pain
This trial tests a new device called the NOVABLOC system to see if it helps control pain during and after knee replacement surgery. It is for people with osteoarthritis who are having their first knee replacement on one knee.
Daphne, AlabamaAges 21 years+ - NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT07776366Recruiting
Study of disc protein levels and disc wear
This study looks at a protein called periostin in the discs of the lower back to see if it relates to how worn down the discs are, which might help improve future treatments.
Daegu, DaeguAges 20–80 - NCT06479161RecruitingPhase 2
Oral tranexamic acid study for knee replacement patients
This trial tests if taking tranexamic acid (TXA) as a pill can reduce bleeding after total knee replacement surgery. It may help you if you have knee osteoarthritis and are scheduled for a first-time knee replacement.
Hartford, ConnecticutAges 18–89 - NCT07775248RecruitingPhase 4
Long-lasting pain relief after knee replacement
This trial tests a new type of pain medicine that is given during knee replacement surgery and slowly releases pain relief over several days. It may help reduce the need for opioid painkillers after surgery.
Grosse Pointe Farms, MichiganAges 18 years+ - NCT07653841Recruiting
Balance vs. strength training for knee osteoarthritis
This study compares two types of exercise programs (a balance-focused training and a progressive strengthening program) added to usual physical therapy. The goal is to see which works better for reducing knee pain and improving daily function in people with knee osteoarthritis.
Islamabad, ICTAges 40–70 - NCT04992624RecruitingPhase 2
Cannabinoid treatment effects on knee pain and nerve signals
This Phase 2 study tests whether a cannabinoid-related treatment changes how pain works in people with knee osteoarthritis. It uses questionnaires, MRI, and gentle nerve testing to understand if treatment helps pain and pain-related signals.
Ann Arbor, MichiganAges 21–75 - NCT06751160Recruiting
Dry needling vs. soft tissue massage for tight hamstrings
This study compares two treatments—dry needling and soft tissue massage—to see which works better for relieving tight hamstring muscles in people with low back pain.
Lahore, Punjab ProvinceAges 20–40 - NCT06784882RecruitingPhase 4
Continuous vs. single-injection nerve block for outpatient knee replacement
This trial compares two types of nerve blocks for pain control after total knee replacement. You will receive either a one-time injection or a continuous block that delivers medication through a small tube. The goal is to see which method provides better pain relief while allowing you to go home the same day.
La Jolla, CaliforniaAges 18 years+ - NCT06169488Recruiting
Comparing fusion surgery to rehab for chronic low back pain
This trial compares two approaches for chronic low back pain caused by worn discs: lumbar fusion surgery versus a structured multidisciplinary rehabilitation program. It aims to see which treatment provides better long-term relief and function.
DrammenAges 20–65
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Common questions
- Are there clinical trials for chronic knee pain?
- Yes. Clin2 currently lists 135 recruiting chronic knee pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic knee pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic knee pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.