Clinical trials
Chronic Obstructive Pulmonary Disease Severe clinical trials
Below are recruiting chronic obstructive pulmonary disease severe clinical trials, each written for real people, not researchers. We’re tracking 208 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06986070RecruitingPhase 1
Stem cell therapy for mild to moderate COPD
This study tests whether a new type of stem cell (SMS cells) can help people with mild or moderate COPD caused by smoking or pollution. You will receive the treatment by inhalation and be followed to see if your breathing improves.
Melbourne, VictoriaAges 39–69 - NCT07285122RecruitingPhase 1
Inhaled study drug for healthy smokers and people with COPD
This study tests an inhaled medication called RB042 in healthy adults, healthy smokers, and people with COPD. It aims to see how the drug works in the body and whether it is safe, which could help in developing a new treatment for COPD.
Nedlands, Western AustraliaAges 18–80 - NCT06072690Recruiting
COPD and Heart Health Study
This study looks at how COPD affects your breathing and heart health. It is for people who are newly diagnosed with COPD and have a history of smoking.
Kaunas, Kaunas CountyAges 40 years+ - NCT07509606Recruiting
Whole body vibration for healthy adults and COPD patients
This study tests if a vibrating platform can help people with COPD and healthy adults. You stand on a machine that gently vibrates to improve muscle function and breathing.
TainanAges 18 years+ - NCT07261293Recruiting
Blood flow restriction exercise for COPD patients
This study tests whether adding mild blood flow restriction to aerobic exercise can improve lung function, exercise capacity, and inflammation in people with stable COPD. You would exercise on a bike or treadmill while wearing soft cuffs on your legs to lightly restrict blood flow.
IstanbulAges 40–80 - NCT07640451RecruitingPhase 2
HRS-9821 inhalation treatment for moderate to severe COPD
This trial tests whether an inhaled medication called HRS-9821 can help people with moderate to severe COPD (chronic obstructive pulmonary disease) breathe better and reduce symptoms. You inhale the medication, and researchers will measure how well your lungs work and how you feel over time.
Shanghai, Shanghai MunicipalityAges 40–80 - NCT05844462RecruitingPhase 3
Tadalafil for severe lung blood-pressure problems from COPD
This study tests whether tadalafil can improve outcomes for people with severe pulmonary hypertension caused by COPD (chronic lung disease). It compares how you do with tadalafil versus standard care, focusing on breathing symptoms and how well your heart and lungs cope.
Le Kremlin-Bicêtre, FranceAges 18–85 - NCT05989698Recruiting
Validating a wearable cough monitor (C-mo)
This study tests a wearable device (C-mo) that monitors coughing. It is for people of all ages who are currently coughing and can cooperate with wearing a small sensor on their belly for a short time.
AlfenaAges 2 years+ - NCT07519603Recruiting
Exercise program for older adults with COPD and frailty
This study tests whether a structured exercise and training program called VIVIFRAIL can help older adults with COPD feel stronger and more independent. You'll participate in guided physical activities designed to improve your strength and daily functioning.
Hanoi, HanoiAges 60 years+ - NCT07363694RecruitingPhase 2/Phase 3
Study of PF-07275315 for moderate to severe COPD
This trial tests a new medicine called PF-07275315 for people with moderate to severe COPD. It aims to see if it can help reduce flare-ups (sudden worsening of symptoms) when added to your usual treatment.
Birmingham, AlabamaAges 35–80 - NCT07789899RecruitingPhase 1
Safety study of a new investigational drug in healthy volunteers
This trial tests a new medicine to see how the body handles it and whether it is safe. It is for healthy people, not for treating a disease, and helps researchers decide if the drug can move to the next stage of testing.
CambridgeAges 18–55 - NCT07854210Recruiting
High-flow nasal oxygen versus non-invasive ventilation for COPD
This trial compares two breathing support methods for people hospitalized with COPD and mild-to-moderate carbon dioxide retention. It aims to see if high-flow nasal oxygen is as effective as the standard mask-based ventilation.
Al Mansurah, Dakahlia GovernorateAges 40 years+ - NCT07428785Recruiting
Measuring lung and blood volume in COPD
This study looks at how COPD affects the amount of air your lungs can hold and the total blood in your body. The goal is to better understand the disease, which may help improve future treatments.
CopenhagenAges 45–80 - NCT06756646Recruiting
Aerobic exercise and BFRT for COPD patients
This trial tests if adding a special band (BFRT) to walking or biking can help people with COPD breathe better and get stronger. It may be a good option if you have moderate to very severe COPD and haven't been in a rehab program lately.
Tainan, TaiwanAges 30–85 - NCT07307781Recruiting
Study of COPD patients with frequent flare-ups in Moscow
This study tests a new treatment for people with COPD who still have frequent flare-ups despite using two maintenance inhalers. It aims to see if the study medicine can reduce these flare-ups.
MoscowAges 18–100 - NCT06883305RecruitingPhase 3
Testing tezepelumab for moderate to severe COPD
This trial tests tezepelumab, an injected medication, for people with moderate to very severe COPD who still have flare-ups despite using standard inhalers. It may help reduce flare-ups and improve breathing for those with higher eosinophil levels.
Foley, AlabamaAges 40–80 - NCT07805330Recruiting
Blood flow restriction rehab for COPD balance and mobility
This study tests a special exercise method that uses a cuff to limit blood flow in the arms or legs while you exercise. It may help improve your balance and ability to move around if you have COPD.
LahoreAges 20–65 - NCT07059091RecruitingPhase 2
Allergy medicine for COPD with indoor allergies
This study tests if omalizumab, an allergy medicine, can help people with COPD who are allergic to common indoor allergens and have had recent flare-ups. It aims to see if reducing allergic reactions can improve COPD control.
Birmingham, AlabamaAges 40 years+ - NCT06961214RecruitingPhase 3
Depemokimab for COPD with type 2 inflammation
This study tests a new biologic medicine, given as an injection, to see if it can reduce flare-ups in adults with COPD who have a certain type of inflammation. It may help people who still have frequent exacerbations despite using their current inhalers.
Sheffield, AlabamaAges 40–80 - NCT06959095RecruitingPhase 3
Depemokimab for adults with COPD and type 2 inflammation
This trial tests a new biologic medicine called depemokimab, given as an injection, to see if it reduces flare-ups (exacerbations) in people with COPD who have a specific type of inflammation (high eosinophils). It may help if you have frequent flare-ups despite using your regular inhalers.
Bakersfield, CaliforniaAges 40–80 - NCT07402551RecruitingPhase 2
Testing RC1416 injection for COPD flare-ups
This trial tests an injection called RC1416 for people with moderate-to-severe COPD who still have flare-ups despite using triple inhaler therapy. It may help reduce those flare-ups and improve breathing.
Hefei, AnhuiAges 40–85 - NCT07860008Recruiting
Breathing and step exercises for COPD wellness
This study tests a program combining breathing training with step exercises to see if it improves breathing, exercise ability, and quality of life in people with COPD. You may join if you have COPD and are able to do light exercise and fill out questionnaires.
New Taipei City, New Taipei CityAges 40 years+ - NCT07780669RecruitingPhase 3
Study of a new drug for moderate to severe COPD in smokers
This study tests a new medication (GSK5784283) for people with moderate to severe COPD who have a certain type of inflammation (eosinophilic). Participants must be on standard inhaler therapy and have a history of smoking. The trial will compare the new drug to a placebo.
Doral, FloridaAges 40–80 - NCT07777445Recruiting
Oxygen treatment during exercise for lung and pulmonary vascular disease
This study compares breathing normal air versus low-flow liquid oxygen during exercise to see if oxygen helps improve performance in people with conditions affecting the lungs or the blood vessels in the lungs. You would exercise while using a portable oxygen device and then without it to compare the effects.
Zurich, Canton of ZurichAges 18 years+
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Common questions
- Are there clinical trials for chronic obstructive pulmonary disease severe?
- Yes. Clin2 currently lists 208 recruiting chronic obstructive pulmonary disease severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic obstructive pulmonary disease severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic obstructive pulmonary disease severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.