Clinical trials
Chronic Pain Management clinical trials
Below are recruiting chronic pain management clinical trials, each written for real people, not researchers. We’re tracking 219 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04996628Recruiting
Testing nerve pain signals to guide treatment for chronic pancreatitis pain
This study checks how your nerves respond to controlled touch and temperature tests, to help predict how well you’ll respond to procedures that relieve blockage in the main pancreatic duct. It may help doctors choose the most effective treatment for chronic pancreatitis pain.
Indianapolis, IndianaAges 18 years+ - NCT03836248Recruiting
Osteopathic care added to standard treatment for chronic low back pain
This study tests whether adding osteopathic treatment to usual medical care can improve chronic low back pain. It focuses on people whose back pain has no clear structural cause and has lasted more than 3 months.
ToulouseAges 18–64 - NCT03675386Recruiting
Help reducing opioid use after surgery for chronic pain
This trial tests a program to help people with long-term (chronic) pain use less opioid medicine after surgery. It may help you reduce opioid doses while still managing your pain.
Toronto, OntarioAges 18 years+ - NCT07680998Recruiting
Pain monitor device for recovery after day surgery
This trial tests a device that monitors pain and recovery after outpatient surgery. It may help manage pain more safely and improve your comfort after you go home.
Nîmes, GardAges 18 years+ - NCT07682519Recruiting
Home vs. in-person rehab for hemophilia pain
This study compares a rehabilitation program you can do at home using video calls (telerehabilitation) with in-person rehabilitation sessions. The goal is to see if the home-based option works as well as office visits for reducing chronic joint pain in adults with hemophilia.
Santiago, Santiago MetropolitanAges 18–60 - NCT07432841Recruiting
Personalized brain stimulation for chronic pain
This trial tests a personalized form of brain stimulation (high-definition tDCS) to treat chronic pain that has not improved with other treatments. If you have had pain for at least 6 months and it is still moderate to severe, this may be an option to explore.
MilanAges 18–75 - NCT07270588Recruiting
MobACT: Online support for chronic pain
This trial tests an internet-based program to help people manage chronic pain. You participate from home using a computer or tablet.
BolognaAges 18 years+ - NCT05700279Recruiting
PTSD treatment to help prevent future chronic pain
This study tests whether treating post-traumatic stress disorder (PTSD) right when you come to the emergency room for new, acute pain can lower the chance you develop long-term (chronic) pain. It may help people whose pain and trauma symptoms start around the same time.
Chicago, IllinoisAges 18–70 - NCT05701852Recruiting
Study brain scans during tasks in chronic nerve pain
This study looks at how brain activity changes in people with long-lasting nerve pain using an MRI scan while you do simple behavioral tasks. It may help researchers understand brain function in chronic neuropathic pain and how it affects day-to-day abilities.
ParisAges 18 years+ - NCT07818980Recruiting
An online pain management program for Canadian veterans
This study is testing an online pain management program designed for Canadian veterans. If you have chronic pain, joining could help you learn ways to manage pain from home.
Toronto, OntarioAges 18–80 - NCT07810218Recruiting
Personalized exercise for chronic pelvic pain
This study tests whether a smartphone app can give you personalized exercise recommendations to help reduce chronic pelvic pain, which may come from conditions like endometriosis or fibroids. You'll track your symptoms and activity daily, and the app will learn what works best for you.
New York, New YorkAges 18–55 - NCT06344169RecruitingPhase 2/Phase 3
Pain relief after C-section with Naldebain
This trial tests a long-acting painkiller, Naldebain, for women having a planned C-section. It aims to see if it provides better pain control after the surgery.
Dalin, Chai-YiAges 20 years+ - NCT06861920RecruitingPhase 4
NSAID use for painful periods to prevent chronic pelvic pain
This study tests whether using NSAIDs (like naproxen) for painful periods can help prevent chronic pelvic pain later on. It's for people with regular, painful periods who are otherwise healthy.
Evanston, IllinoisAges 18–35 - NCT06574269RecruitingPhase 2
Study on TLC590 for pain after surgery
This trial tests a new pain medicine, TLC590, for people having one of several common surgeries, like bunion removal, hernia repair, breast augmentation, knee replacement, or tummy tuck. The goal is to see if it helps manage pain after the procedure.
Bellaire, TexasAges 18–70 - NCT06442566RecruitingPhase 1/Phase 2
Enhancing opioid therapy for chronic pain with buprenorphine, counseling, and brain stimulation
This study is testing whether adding a medication (buprenorphine), counseling, and a type of brain stimulation (TMS) can improve long-term opioid therapy for chronic pain. If you have been taking prescription opioids daily for at least 3 months and have extra risk factors for opioid-related problems, this trial may offer you new ways to manage pain and reduce risks.
Charleston, South CarolinaAges 18 years+ - NCT06377969Recruiting
Spinal cord stimulation for chronic pelvic pain
This study tests a device called a spinal cord stimulator — a small implant that sends mild electrical pulses to nerves in your spine — to see if it can reduce long-term pelvic pain that hasn't gotten better with other treatments.
Redwood City, CaliforniaAges 18 years+ - NCT06150599Recruiting
Sacral nerve stimulation for chronic pelvic pain
This study tests whether a pacemaker-like device placed near the tailbone can reduce long-term pelvic pain in women who haven't gotten relief from other treatments.
Royal Oak, MichiganAges 22–70 - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT07199361Recruiting
Magnetic stimulation for chronic pain after injury or surgery
This study tests a non-invasive magnetic device placed on the skin to see how it relieves chronic pain caused by a past injury or surgery. It may help people who have had pain for at least three months and take medication for it.
Miami, FloridaAges 19–80 - NCT07301632RecruitingPhase 2
MDMA for severe chronic nerve pain
This trial tests if MDMA, combined with psychotherapy, can help people with severe chronic nerve pain that hasn't improved with standard treatments. You'll receive either MDMA or a placebo to see if it safely reduces pain and improves your quality of life.
Toronto, OntarioAges 18 years+ - NCT07096661Enrolling by invitation
Pain education for labor and postpartum pain
This study tests a way of teaching about pain (called pain science education) to help healthcare professionals better support women during labor and after birth. If you are a healthcare professional who works with pregnant or new mothers, this trial may be for you.
BournemouthAges Any age - NCT06932406Recruiting
Personality and self-help for jaw pain
This study tests whether a self-management program for jaw and face pain works differently in people with different personalities. You will learn techniques to manage your pain at home.
Valencia, ValenciaAges 18–65 - NCT06246929Recruiting
Healthy aging for Black adults with chronic pain and memory concerns
This study tests a program to help Black adults aged 50+ manage chronic pain and early memory changes. It compares two approaches to see which works better for improving daily life and thinking skills.
Boston, MassachusettsAges 50 years+ - NCT06029075Recruiting
Brain stimulation for nerve pain after spinal injury
This study tests whether a gentle electrical current applied to the scalp can help relieve nerve pain that continues after an injury to the spinal cord, arm or leg amputation, or brain injury. Participants will continue their usual pain medications during the trial.
Houston, TexasAges 18–75
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Common questions
- Are there clinical trials for chronic pain management?
- Yes. Clin2 currently lists 219 recruiting chronic pain management studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain management trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain management trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.