Clinical trials
Chronic Pain Management clinical trials
Below are recruiting chronic pain management clinical trials, each written for real people, not researchers. We’re tracking 221 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06595329RecruitingPhase 1
Pain relief after kidney cancer surgery: epidural vs spinal opioids
This trial compares two ways to manage pain after open kidney cancer surgery: an epidural (a thin tube placed near your spine) versus a single spinal injection of opioids. Both aim to control pain, but the study wants to see which method works better, with fewer side effects.
SplitAges 18 years+ - NCT07127380Recruiting
Comparing two types of spine surgery for disc-related low back pain
This study compares two different surgery methods (Mini-TLIF and MIDLIF) for treating low back pain caused by worn-out discs in the lower back. The goal is to see which one offers better recovery, fewer complications, and lower costs.
Lodz, Łódź VoivodeshipAges 18 years+ - NCT07185425Recruiting
NeuroCuple patch for pain after C-section
This study tests a special sticky patch (NeuroCuple device) placed near your C-section incision to see if it helps with pain after delivery. It may offer a drug-free way to manage discomfort.
Falls Church, VirginiaAges 18 years+ - NCT07396753Recruiting
Nerve block to reduce opioid use after kidney donor surgery
This study tests a nerve block called Transversalis Fascia Plane Block to see if it lowers the amount of strong pain medicine (opioids) needed after a kidney donor surgery. It may help you have less pain and fewer side effects.
Istanbul, ZeytinburnuAges 18–80 - NCT07401147Recruiting
TENS for pain relief during first labor
This trial tests a gentle electrical device (TENS) to help manage pain during labor. It's for women having their first baby, with a healthy, single pregnancy, and no major health issues.
Tegucigalpa, Francisco Morazán DepartmentAges 18–45 - NCT05009771Recruiting
Testing a pain-control method after C-section
This study looks at how to better manage pain after a C-section using spinal anesthesia and either a patient-controlled IV pain pump or a specific pain medicine (naldebaein). You may be able to join if you’re scheduled for a C-section at 37–40 weeks and can take the usual pain medicines.
New Taipei City, TaiwanAges 20–40 - NCT07166952Recruiting
Nerve Stimulation for Chronic Sacroiliac Joint Pain
This study tests whether the SPRINT system, a device that uses mild electrical pulses to block pain signals from the sacroiliac joint, can help people with chronic pain in that area. It aims to see if this treatment works well for those who have not improved with other therapies.
Charleston, South CarolinaAges 18 years+ - NCT07743606Enrolling by invitationPhase 3
Pain medicine after lower back fusion surgery
This study tests whether taking a nonsteroidal anti-inflammatory drug (NSAID) like ibuprofen after lumbar spine fusion surgery is safe and helps with pain without affecting bone healing. It may offer an alternative to stronger pain medicines.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06183281Recruiting
Comparing two non-drug approaches for chronic pain
This study compares two different ways to help people manage chronic pain without using medications. Over 12 months, you'll use a smartphone app and learn strategies to feel better and have more control over your pain.
San Francisco, CaliforniaAges 18 years+ - NCT06353529RecruitingPhase 4
Pain management after pituitary tumor surgery
This study tests a nerve block (called sphenopalatine ganglion block) for pain relief after pituitary tumor surgery through the nose. It aims to see if this block helps manage pain and reduces the need for other pain medicines.
Hamilton, OntarioAges 18–100 - NCT06623669RecruitingPhase 2
Mobile program to reduce pain and improve health in older adults
This trial tests a mobile program to help reduce pain and improve health in older adults with knee or hip arthritis who are not very active. The program involves exercise and may help with weight management.
Winston-Salem, North CarolinaAges 65 years+ - NCT04144972Recruiting
Closed-loop deep brain stimulation for long-lasting nerve pain
This trial tests a “smart” deep brain stimulation device that senses your brain signals and adjusts treatment to reduce severe, long-lasting pain. It may help people whose pain has not improved with multiple pain medicines and surgery cannot fix the cause.
San Francisco, CaliforniaAges 22–80 - NCT07750626Recruiting
Vibration and ShotBlocker for injection pain in children
This study tests two methods to reduce pain and fear during a shot in the emergency department. It compares using a vibration device or a ShotBlocker device against standard care.
BurdurAges 5–10 - NCT06502457Recruiting
Virtual reality hypnosis for labor pain
This study tests whether using a virtual reality hypnosis program can help manage pain during early labor in women with low-risk pregnancies. If you are in the beginning stages of labor and want a non-drug option for comfort, this might be for you.
AmiensAges 18 years+ - NCT06995287RecruitingPhase 3
Botulinum toxin injection for severe period pain
This trial tests whether injecting botulinum toxin into the uterine muscle during a hysteroscopy can reduce severe period pain or chronic pelvic pain that hasn't improved with standard treatments. It may be an option for women who have tried hormonal therapy and pain relievers without success.
Aix-en-ProvenceAges 18 years+ - NCT07158476RecruitingPhase 4
Steroid injection for pain after ACL repair
This trial tests whether a single dose of methylprednisolone (a steroid) can reduce pain after ACL knee surgery. You will be randomly assigned to receive either the steroid or a placebo, and your pain levels will be tracked.
St Louis, MissouriAges 13–50 - NCT06240299Recruiting
Neurofeedback for chronic pain in rheumatoid arthritis
This trial tests a brain-training technique called neurofeedback to see if it can help people with rheumatoid arthritis who also have chronic widespread pain. It uses a computer to show you your brain activity and teach you to control it, which may reduce pain.
Glasgow, ScotlandAges 18–75 - NCT06725550Recruiting
Acupuncture for pain in sickle cell disease
This trial tests whether adding acupuncture to standard pain treatments can help manage pain in people with sickle cell disease. It involves brain scans, questionnaires, and acupuncture sessions to see if this approach reduces pain and improves quality of life.
Cincinnati, OhioAges 14–80 - NCT06819956RecruitingPhase 3
Lower-dose ketorolac for pain in the ICU
This trial tests whether a lower dose of the pain medicine ketorolac can safely control pain for people in the intensive care unit (ICU). If you are in the ICU and have pain, this study might help find a better way to treat it.
Edmonton, AlbertaAges 18 years+ - NCT07442539Recruiting
Numbing medicine for pain after hemorrhoid surgery
This trial tests a long-acting numbing medicine called liposomal bupivacaine to see if it reduces pain after hemorrhoid surgery better than standard care. It may be an option for people who are otherwise healthy and scheduled for this surgery.
Beijing, Beijing MunicipalityAges 18–64 - NCT07560267Recruiting
Ultrasound nerve block for kidney surgery pain relief
This trial tests whether a special nerve-numbing injection in the back (guided by ultrasound imaging) can reduce pain after kidney removal surgery. If it works well, it could help patients recover more comfortably with less need for strong pain medications.
DhakaAges 18–64 - NCT07600203Recruiting
Low-level laser therapy for chronic jaw pain
This study tests whether a special laser device called the Erchonia EVRL can reduce chronic jaw pain caused by TMJ (temporomandibular joint) disorders. You would receive laser treatment and rate your pain over time to see if the laser helps more than a placebo.
Acton, MassachusettsAges 22–75 - NCT07691840Recruiting
Intrathecal therapy vs. standard care for severe cancer pain
This trial compares a treatment that delivers pain medicine directly to the spinal cord (intrathecal therapy) with usual pain control. It is for people with severe cancer pain that is not helped by oral or intravenous opioids.
JetteAges 18 years+ - NCT06886932Recruiting
Pain education after rotator cuff surgery
This trial tests if learning about pain before and after rotator cuff repair helps people recover better. It might help you if you have a medium-sized tear and are planning surgery.
KaramanAges 40–75
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Common questions
- Are there clinical trials for chronic pain management?
- Yes. Clin2 currently lists 221 recruiting chronic pain management studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain management trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain management trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.