Clinical trials
Chronic Total Occlusion of Coronary Artery clinical trials
Below are recruiting chronic total occlusion of coronary artery clinical trials, each written for real people, not researchers. We’re tracking 68 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT01889459Recruiting
Registry after stent procedure for blocked heart arteries
This study follows people who had a stent placed for a long-standing blockage in a heart artery (called a CTO). It’s mainly a “registry” to understand outcomes after these procedures and help improve care in the future.
KurashikiAges 20 years+ - NCT05230446Recruiting
Testing full stent treatment for heart artery blockages
This study looks at how well doctors can treat multiple blocked heart arteries using a specific drug-eluting stent, aiming to fully open them. It may help patients whose blockage pattern fits the study, but it does not include certain high-risk or special cases.
Rotterdam, South HollandAges 18–85 - NCT04944615Recruiting
IVUS-guided stent placement for blocked heart artery using longer guidance
This trial compares two ways to place a stent (a small mesh tube) for a completely blocked heart artery: using an IVUS camera inside the artery versus using a standard x-ray approach. It may help people get better heart outcomes by improving how accurately the stent is placed in long-term blockages.
BeijingAges 18 years+ - NCT07811024Recruiting
Strolimus-coated balloon for blocked coronary arteries
This study tests a balloon coated with a drug that may help keep arteries open after they've been cleared, especially for people with a narrowing inside a previously placed stent or in a small heart artery. It's a first-time-in-humans study to check if the treatment is safe and works.
TashkentAges 21 years+ - NCT06567938Recruiting
Heart artery procedure study for people with kidney disease
This trial uses a special ultrasound camera inside the heart's arteries to guide stent placement for people with chronic kidney disease. The goal is to see if this approach improves outcomes compared to standard methods.
Xi'an, ShaanxiAges 18 years+ - NCT06075602Recruiting
Complex and calcified coronary artery disease: a registry study
This study watches how people with complex or calcified heart artery disease are treated (with stents or bypass surgery) and how they do over time. It aims to learn which treatments work best for tough blockages.
Lucerne, Canton of LucerneAges 18 years+ - NCT07463664Recruiting
Drug-coated balloons for blocked heart arteries
This trial tests whether a drug-coated balloon, used without a permanent stent, can safely open completely blocked heart arteries that have been blocked for at least 3 months. It may offer an option that avoids leaving a metal stent behind.
Beijing, Beijing MunicipalityAges 18–80 - NCT07407738Recruiting
A trial of a shockwave device for calcified heart arteries
This trial tests a new device that uses sound waves to break up calcium deposits in heart arteries before placing a stent. It is for people with severely hardened arteries that are hard to treat with standard methods.
LyonAges 18 years+ - NCT07369765Recruiting
Balloon vs stent for blocked arteries
This trial compares two procedures to open completely blocked coronary arteries: a drug-coated balloon or a drug-eluting stent. It may help patients with a single, medium-length blockage in a large enough artery.
IstanbulAges Any age - NCT07329699Recruiting
AI-Guided Heart Artery Pressure Test vs Standard Test
This study compares a new artificial intelligence (AI) method to measure blood flow in your heart arteries (called Medipixel FFR) with the standard invasive method. If you are scheduled for a heart angiogram or stenting and have a moderate blockage (40-90% narrowing) that doctors are unsure about, this AI tool may help decide the best treatment for you.
Seoul, Select StateAges 19 years+ - NCT07314138Recruiting
Comparing two minimally invasive heart bypass surgeries for three-vessel disease
This trial compares two types of heart bypass surgery for people with blockages in three main heart arteries. It tests a hybrid approach that combines a small incision bypass with a stent, versus a standard off-pump bypass. This may mean less recovery time for some patients.
Leuven, Vlaams BrabantAges 18–85 - NCT07114393Recruiting
Better imaging to guide complex heart artery procedures
This study looks at whether using advanced imaging inside the heart arteries during complex procedures leads to better outcomes compared to current standard practice. If you have had a complex angioplasty (PCI) and your data is in a national heart registry, you may be included.
Eindhoven, North BrabantAges 18 years+ - NCT06606821RecruitingPhase 4
Tirzepatide for heart health in people with overweight or obesity
This trial tests the weight‑loss medication tirzepatide (Mounjaro) in people who are overweight or have obesity and have stable coronary artery disease. The goal is to see if tirzepatide can reduce dangerous fatty plaque in heart arteries.
CopenhagenAges 18 years+ - NCT06985693Recruiting
AI-assisted stent placement study for heart disease
This trial tests whether a new artificial intelligence tool called Medipixel XA can help doctors place stents more precisely in blocked heart arteries. If you have coronary artery disease and need a stent, this study could be an option.
Gwangmyeong, Gyeonggi-doAges 19 years+ - NCT07020858Recruiting
FAPI imaging for heart attack risk in blocked arteries
This trial tests whether a special scan called FAPI-PET can predict heart problems in people with a chronic total occlusion (a completely blocked heart artery for at least 3 months). If you have this type of blockage and are planning to have a procedure to open it, this study may help guide your care.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07013344Recruiting
Link between NT-proBNP and heart artery disease
This study looks at a blood test called NT-proBNP to see if it can help predict how much blockage is in the heart's arteries. It may help doctors better understand heart disease risk.
Milan, ItalyAges 18 years+ - NCT06400290Recruiting
Balloon test to find which artery causes chest pain
This study tests a new way to find which blocked heart arteries are causing your chest pain. During a stent procedure, doctors will briefly block each artery to see which one triggers your symptoms. This might help them decide which blockages to treat.
BasildonAges 18 years+ - NCT06795763Enrolling by invitation
New imaging & catheter system for blocked heart arteries
This trial tests a new imaging and catheter system to treat chronic total blockages in heart arteries. If you still have chest pain or other symptoms despite medical therapy, this study may help open the blockage and improve blood flow.
Atlanta, GeorgiaAges 18 years+ - NCT06710210Recruiting
Combining two heart treatments for long blocked arteries
This study tests a new way to treat long, narrow blockages in the heart's arteries. It combines a temporary scaffold with a drug-coated balloon, which may help the artery heal without a permanent metal stent. This could be an option for people who need their artery opened but may benefit from a less permanent approach.
Geneva, Canton of GenevaAges 18 years+ - NCT06625801Recruiting
IVUS-guided heart procedure registry for minority patients
This study is collecting information from heart procedures that use IVUS (a special ultrasound inside the blood vessels) to treat complex blockages. It aims to learn how well these procedures work in patients who identify as a racial or ethnic minority.
Phoenix, ArizonaAges 18 years+ - NCT06535568Recruiting
Comparing one vs two blood thinners after heart artery balloon treatment
This trial tests whether taking just one blood thinner (clopidogrel) is as safe and effective as taking two (clopidogrel plus aspirin) for older adults or people at high bleeding risk who have had a drug-coated balloon procedure to open blocked heart arteries.
Milan, MIAges Any age - NCT06492733Recruiting
FastWire device for unblocking leg arteries (FREEFLOW trial)
This trial tests a new wire system to reopen completely blocked leg arteries without surgery. It is for people with severe leg pain or tissue damage caused by blocked arteries, and aims to restore blood flow and improve walking ability.
Wilmington, DelawareAges 18–85 - NCT06193954Recruiting
Vibrating guidewire for chronic heart artery blockages
This trial tests a special vibrating guidewire to help open heart arteries that have been completely blocked for a long time, when standard wires have failed. It may help you if you have a stubborn blockage requiring a gentle approach.
Atlanta, GeorgiaAges 18 years+ - NCT06373601Recruiting
Testing a drug-coated balloon for small heart arteries
This study tests a drug-coated balloon (DCB) that releases two medicines (sirolimus and paclitaxel) to open blocked small heart arteries. It may help people with stable chest pain or recent, controlled heart events who have a narrowed small vessel.
Mercogliano, Italy/AvellinoAges 18 years+
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Common questions
- Are there clinical trials for chronic total occlusion of coronary artery?
- Yes. Clin2 currently lists 68 recruiting chronic total occlusion of coronary artery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic total occlusion of coronary artery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic total occlusion of coronary artery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.