Clinical trials
Cognitive Decline clinical trials
Below are recruiting cognitive decline clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06853405Recruiting
Nutrition program to prevent memory decline
This study tests whether nutrition-based changes can help prevent memory loss and thinking problems in people who are at higher risk for dementia. To join, you need to be between 55 and 85, have at least 4 years of schooling, and have an elevated dementia risk score.
Porto, PortugalAges 55–85 - NCT06746844Enrolling by invitation
Memory and thinking study for adults ages 45 to 95
This study looks at a new way to measure thinking and memory changes using a computer task. It might help people who have noticed memory problems or who want to track their brain health.
Buenos Aires City, Buenos AiresAges 45–95 - NCT03657745Recruiting
40 Hz light and brain training for Alzheimer’s
This trial tests whether a combination of 40 Hz light stimulation and cognitive (thinking) therapy can improve symptoms in people with Alzheimer’s disease. It may help by stimulating the brain and training thinking skills, while carefully checking eye and seizure history.
Miami, FloridaAges 50 years+ - NCT07547319Recruiting
Accelerated rTMS to improve cognitive function
This study tests whether repeated magnetic pulses to the brain (called rTMS) can help improve thinking and memory in older adults with mild to moderate cognitive decline. The treatment is non-invasive and may help slow cognitive changes.
San Francisco, CaliforniaAges 50–90 - NCT07226674Recruiting
Study of gut health and plant nutrients for brain health
This trial tests whether a natural plant compound can help support memory and thinking in people at higher risk for Alzheimer's disease. You may qualify if you are over 50, overweight, eat a typical Western diet, and have a family history of Alzheimer's.
ColeraineAges 50 years+ - NCT06248723Recruiting
Preventing memory decline in older adults with lifestyle changes
This study tests a personalized program of lifestyle changes (diet, exercise, brain training, etc.) to see if it can prevent memory loss and keep older adults independent. You may qualify if you are 60+, have mild frailty, and have certain risk factors for dementia.
MonzaAges 60 years+ - NCT06627894Recruiting
Online therapy for depression after ICU stay
This trial tests if an online cognitive behavioral therapy program can help reduce depression and slow down thinking and memory problems in older adults who have been in the intensive care unit (ICU). It looks at whether treating depression can protect your brain health after a serious illness.
Indianapolis, IndianaAges 50 years+ - NCT04635657Recruiting
Testing brain function after meningioma surgery
This study measures how thinking and memory change after surgery to remove a meningioma near the front or side of the brain. It may help doctors better understand what to expect and how cognitive recovery can differ from person to person.
Columbus, OhioAges 18–89 - NCT04171323Recruiting
Active mind training to improve thinking and delay dementia
This study tests an “active mind” computer-based program to help improve thinking skills and possibly slow the process toward dementia. You may be randomly assigned to different program options to see which approach works best for your goals.
San Francisco, CaliforniaAges 55–89 - NCT07242495Recruiting
Virtual reality with exercise for memory in older adults
This trial tests whether using 360-degree virtual reality videos during aerobic exercise can improve thinking and memory in older adults with mild cognitive impairment. It's a chance to try a new approach that combines exercise and immersive technology.
IslamabadAges 60 years+ - NCT05106036Recruiting
Lowering BP targets to prevent memory and thinking decline
This study tests whether setting a lower blood pressure goal can help prevent future memory and thinking problems in older adults. It compares a more intensive blood pressure plan with usual care to see if it better protects the brain over time.
Dallas, TexasAges 70 years+ - NCT07182396Recruiting
Video games vs ball tossing for hand-eye coordination in older adults
This study tests whether playing video games or tossing balls can improve hand-eye coordination in older adults with mild memory problems. It is designed for people 60 and older who have mild cognitive impairment but are otherwise independent.
IslamabadAges 60 years+ - NCT06993207Recruiting
Home brain monitoring study for cognitive decline
This study uses a special EEG headband to monitor brain activity at home in older adults. It aims to understand cognitive decline, including Alzheimer's and mild memory problems, and compare results with healthy volunteers.
Zaragoza, ZaragozaAges 60 years+ - NCT07717567Recruiting
Blood tests to diagnose and predict Alzheimer's disease
This study is testing whether a simple blood test can help diagnose Alzheimer's disease and predict how the disease will progress. If you have memory or thinking problems that have been getting worse, you may be able to join.
Milan, MilanoAges 40 years+ - NCT06223672Recruiting
Healthy fats for better thinking in older adults
This study tests whether healthy fats can help improve thinking and memory in people with mild memory concerns. It is for people with overweight and normal blood sugar.
Columbus, OhioAges 40–75 - NCT07141160Enrolling by invitation
ADL+2.0 to prevent memory decline in older adults
This trial tests a program called ADL+2.0 to see if it can help prevent memory problems in older adults who live in the community. If you are 60 or older, have some memory concerns but can still do daily activities independently, you may be able to join.
SingaporeAges 60–99 - NCT04184375Recruiting
Memory training for older adults with bipolar disorder
This study tests whether structured memory and thinking exercises (cognitive stimulation) help older adults with bipolar disorder who have mild to moderate thinking and memory problems. You may be offered guided sessions designed to improve everyday thinking skills while checking safety and fit for the program.
La RochelleAges 65 years+ - NCT06650969Recruiting
Early detection of cognitive decline in type 2 diabetes
This study is looking at ways to catch early thinking and memory changes in people with type 2 diabetes. By joining, you may help doctors learn how to spot problems sooner and find better ways to help.
Nanjing, JiangsuAges 45 years+ - NCT06513403Recruiting
Using AI to detect memory loss from facial expressions
This study uses artificial intelligence to analyze your facial expressions and see if it can help tell the difference between healthy aging, mild memory loss, and dementia. It's a simple, non-invasive way to explore early detection of cognitive decline.
HsinchuAges 50–75 - NCT04493996Recruiting
Cognitive training before heart surgery to protect memory
This trial tests whether brain-focused cognitive training before elective heart surgery can help reduce memory and thinking problems afterward. If you qualify, you may do language-based thinking exercises and complete short brain tests around the time of surgery.
Bad NauheimAges 18 years+ - NCT06010511Recruiting
White matter changes and brain fluid study in older adults
This study uses special MRI scans to look at white matter changes in the brain (often linked to memory problems). It may help doctors understand more about these changes in older adults visiting memory or geriatric clinics.
LeidenAges 65 years+ - NCT07011680Recruiting
Dairy Extract for Memory Support in Older Adults
This study tests whether a special dairy extract (phospholipid-rich) can help support memory in people aged 55-85 who notice some forgetfulness but do not have dementia. You will be asked to take the extract daily and have periodic memory assessments.
YangsanAges 55–85 - NCT07334366Recruiting
Broccoli sprout extract study for memory
This study tests whether a broccoli sprout extract can help support memory and thinking skills in older adults who notice memory changes but do not have dementia. If you are between 55 and 85, have mild memory concerns, and can read Korean, you may be able to join.
YangsanAges 50–85 - NCT07000500Enrolling by invitation
Nutritional supplement for memory decline in older adults
This trial tests whether a nutritional supplement can help slow or improve memory loss in older adults who have mild cognitive decline (noticeable changes in thinking skills that are not yet dementia). You will take a daily supplement and attend regular check-ups.
Vila Nova de Famalicão, Braga DistrictAges 65 years+
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Common questions
- Are there clinical trials for cognitive decline?
- Yes. Clin2 currently lists 181 recruiting cognitive decline studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive decline trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive decline trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.