Clinical trials
Cognitive Dysfunction clinical trials
Below are recruiting cognitive dysfunction clinical trials, each written for real people, not researchers. We’re tracking 150 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05201534Recruiting
Math and thinking skills training for school-age children
This trial studies interventions to improve math and cognitive (thinking) skills in elementary school children. It includes both children with math learning difficulties and typically developing children, using tests and MRI brain scans for those who can participate.
Palo Alto, CaliforniaAges 6–12 - NCT07719712Recruiting
Thinking and confusion after prostate surgery in older adults
This study looks at how older adults' thinking and memory may change after a common prostate surgery, and whether some patients become confused or delirious afterward. It may help doctors understand who is at risk for these problems.
MuğlaAges 65 years+ - NCT04493996Recruiting
Cognitive training before heart surgery to protect memory
This trial tests whether brain-focused cognitive training before elective heart surgery can help reduce memory and thinking problems afterward. If you qualify, you may do language-based thinking exercises and complete short brain tests around the time of surgery.
Bad NauheimAges 18 years+ - NCT07242495Recruiting
Virtual reality with exercise for memory in older adults
This trial tests whether using 360-degree virtual reality videos during aerobic exercise can improve thinking and memory in older adults with mild cognitive impairment. It's a chance to try a new approach that combines exercise and immersive technology.
IslamabadAges 60 years+ - NCT07304674Recruiting
Primary Aldosteronism and Thinking Ability Study
This study looks at whether primary aldosteronism (a treatable cause of high blood pressure) is linked to memory and thinking problems. It may help understand if managing this condition can protect brain health.
Chengdu, SichuanAges 40 years+ - NCT07586501Enrolling by invitation
Brain Health and Immune System Study in Older Adults
This research study examines how the brain's immune system changes in older adults with memory problems, Parkinson's disease, or normal aging. By understanding these changes, researchers hope to better understand neurodegeneration and develop new treatments.
Yantai, ShandongAges 55–75 - NCT03360838Recruiting
Prediction test for confusion after heart surgery in older adults
This study uses a short, self-answered thinking test before elective heart surgery to help predict who may develop confusion afterward. The goal is to improve early identification and care planning for patients at higher risk.
BaselAges 60 years+ - NCT06948903Recruiting
Fibromyalgia, brain sensitivity and thinking
This study looks at how the brain's pain sensitivity (central sensitization) relates to memory and thinking problems in people with fibromyalgia. Participating could help doctors understand and treat these symptoms better.
Istanbul, UskudarAges 18–65 - NCT07182396Recruiting
Video games vs ball tossing for hand-eye coordination in older adults
This study tests whether playing video games or tossing balls can improve hand-eye coordination in older adults with mild memory problems. It is designed for people 60 and older who have mild cognitive impairment but are otherwise independent.
IslamabadAges 60 years+ - NCT06853405Recruiting
Nutrition program to prevent memory decline
This study tests whether nutrition-based changes can help prevent memory loss and thinking problems in people who are at higher risk for dementia. To join, you need to be between 55 and 85, have at least 4 years of schooling, and have an elevated dementia risk score.
Porto, PortugalAges 55–85 - NCT06279325Recruiting
Computer brain training for older adults
This trial studies whether a computer-based brain training program can help thinking skills in older adults. It is designed for people who are generally healthy and have not received similar training before.
Zaragoza, ZaragozaAges 60 years+ - NCT06658769Recruiting
Brain stimulation to prevent confusion after surgery in older adults
This study tests if transcranial magnetic stimulation (a gentle brain stimulation) can help prevent or reduce confusion or memory problems after major surgery in people over 60. If you already have mild memory issues, this might help protect your thinking skills.
São Paulo, São PauloAges 60–120 - NCT06650969Recruiting
Early detection of cognitive decline in type 2 diabetes
This study is looking at ways to catch early thinking and memory changes in people with type 2 diabetes. By joining, you may help doctors learn how to spot problems sooner and find better ways to help.
Nanjing, JiangsuAges 45 years+ - NCT04229056Recruiting
Computer training to improve thinking and planning after stroke or Parkinson’s
This trial tests computer-based “self-training” to improve executive function, such as working memory—your ability to hold and use information in mind. It’s for adults with a prior stroke, cardiac arrest, or Parkinson’s disease who have trouble on a specific working-memory task.
CopenhagenAges 18–100 - NCT05014399Recruiting
Study memory changes during chemotherapy for colorectal cancer
This study looks at cognitive (thinking and memory) changes in people with colorectal cancer who start certain chemotherapy drugs. It aims to understand how treatment affects the brain and may guide better monitoring or support during care.
Fort Wayne, IndianaAges 18 years+ - NCT06969066Recruiting
Memory training for insomnia with memory problems
This trial tests memory training for people who have both insomnia and mild memory issues. It aims to see if this training can improve sleep and memory.
BeijingAges 8 years+ - NCT07000461Recruiting
Doppler test to predict memory problems after heart surgery
This study uses a noninvasive ultrasound test (transcranial Doppler) before heart surgery to see if it can help predict thinking or memory problems that may occur after the operation.
IstanbulAges 18–70 - NCT07334366Recruiting
Broccoli sprout extract study for memory
This study tests whether a broccoli sprout extract can help support memory and thinking skills in older adults who notice memory changes but do not have dementia. If you are between 55 and 85, have mild memory concerns, and can read Korean, you may be able to join.
YangsanAges 50–85 - NCT07526740Recruiting
Brain Stimulation and Training for Mild Memory Loss
This study tests whether combining brain stimulation (TMS) with cognitive training games can help people with mild cognitive impairment—early memory and thinking problems. The goal is to see if this combination improves thinking abilities and slows cognitive decline.
Charleston, South CarolinaAges 60–85 - NCT05245903Recruiting
Test a supplement and track brain changes with wearable sensors
This study tests whether taking nicotinamide riboside (a form of niacin) affects early memory changes in people with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD). It also uses passive wearable or sensor data (“digital biomarkers”) to measure changes over time.
Belmont, MassachusettsAges 18–89 - NCT06733714Recruiting
Brain stimulation plus memory training for older adults
This study tests whether a gentle, non-invasive electrical current applied to the scalp (tACS) combined with computer-based brain exercises can improve memory and thinking in older adults who have concerns about their cognitive health.
Rio de Janeiro, Rio de JaneiroAges 50 years+ - NCT06027632Recruiting
Brain training at home to help with chemo brain after breast cancer treatment
This study tests a supervised computer-based mental exercise program to help reduce memory and thinking problems after chemotherapy. It is for people who finished chemo for early-stage breast cancer and still have bothersome mental fogginess.
BordeauxAges 1.5 years+ - NCT07517237Recruiting
Brain Stimulation and Cognitive Training for Memory and Thinking
This study tests whether a small device that stimulates a nerve in your ear (combined with computerized brain exercises) can help improve memory, attention, and thinking abilities in adults experiencing cognitive changes. You'll use the device at home with an app on your phone or tablet.
Charleston, South CarolinaAges 45–80 - NCT05114876Recruiting
Tested a new plan to support older adults after surgery
This study looks at a redesigned surgical care plan to better support older adults who may have memory or thinking changes after major planned surgery. If you qualify, you would be assessed before surgery and followed after to see whether this approach helps.
Toronto, OntarioAges 60 years+
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Cognitive Dysfunction trials by city
Studies with a site in or near these metro areas.
Cognitive Dysfunction trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for cognitive dysfunction?
- Yes. Clin2 currently lists 150 recruiting cognitive dysfunction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive dysfunction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive dysfunction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.