Clinical trials
Cognitive Decline clinical trials
Below are recruiting cognitive decline clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04840030Enrolling by invitation
Preventing Memory and Thinking Decline With Multidomain Program
This study tests a multi-part program (not just one activity) to help slow down memory and thinking decline in older adults at higher risk. You would complete brief thinking tests and follow the study’s coaching/intervention schedule to see if it helps over time.
Donostia / San Sebastian, GipuzkoaAges 60–85 - NCT04583800Recruiting
Tracking heart failure risk and memory change in diabetes
This study follows adults with type 2 diabetes to see who may develop heart problems and who may have memory or thinking changes over time. It may help doctors better predict risk and plan earlier support.
LilleAges 18 years+ - NCT04806568Recruiting
Cognitive training to help brain flexibility in multiple sclerosis
This study tests whether structured cognitive exercises can improve “neuroplasticity,” meaning how flexible and changeable the brain is. It includes people with multiple sclerosis and healthy volunteers, and uses tasks plus brain scans to see what changes over time.
Thessaloniki, Central MacedoniaAges 18–65 - NCT05114876Recruiting
Tested a new plan to support older adults after surgery
This study looks at a redesigned surgical care plan to better support older adults who may have memory or thinking changes after major planned surgery. If you qualify, you would be assessed before surgery and followed after to see whether this approach helps.
Toronto, OntarioAges 60 years+ - NCT05877196Recruiting
Adaptive walking and fitness program for mild memory decline
This study tests an “adaptive” exercise plan that adjusts over time to help improve aerobic fitness and your body’s fitness response in people with mild memory problems or early Alzheimer’s. It may help you safely build the kind of fitness that supports brain health, while researchers monitor changes with fitness testing and blood work.
Phoenix, ArizonaAges 65 years+ - NCT07594665Enrolling by invitation
Home-based cognitive health blood tests for older adults
This study invites people aged 65+ who are already part of the SHUTi MIND research program to do simple blood tests at home to check for early signs of cognitive changes. The goal is to make it easier for people to access brain-health testing without going to a clinic.
Charlottesville, VirginiaAges 65 years+ - NCT06733714Recruiting
Brain stimulation plus memory training for older adults
This study tests whether a gentle, non-invasive electrical current applied to the scalp (tACS) combined with computer-based brain exercises can improve memory and thinking in older adults who have concerns about their cognitive health.
Rio de Janeiro, Rio de JaneiroAges 50 years+ - NCT06956300Recruiting
TMS to help with thinking and memory in aging
This study uses a noninvasive brain stimulation technique called TMS to see if it can slow cognitive decline in older adults who are healthy or have very early signs of Alzheimer's disease. It aims to improve memory and thinking.
Boston, MassachusettsAges 40–99 - NCT05194787Recruiting
Online tests to spot early Alzheimer’s changes
This study looks at whether online motor (movement) and thinking tasks can detect early changes related to Alzheimer’s disease. You may be able to take part if you’re over 50 and do not already have a diagnosis of dementia.
Hobart, TasmaniaAges 50 years+ - NCT05922137Recruiting
ORIENT diet for brain blood vessel narrowing
This trial studies whether a specific dietary program (the ORIENT diet) can improve brain-related thinking and memory in people with narrowed brain or neck arteries. You may be able to help test whether the diet is safe and beneficial alongside usual care, through repeated assessments over time.
Hangzhou, ZhejiangAges 40 years+ - NCT03860857RecruitingPhase 3
Study biomarkers in memory aging and brain health
This Phase 3 study looks for blood/brain “biomarkers” linked to aging, memory changes, and early brain degeneration. It may help researchers better identify who is at risk and how biology relates to thinking and memory, using brain scans and thinking tests.
Irvine, CaliforniaAges 60 years+ - NCT06051240RecruitingPhase 2
Lithium to prevent thinking problems after brain radiation
This study tests if the drug lithium can help prevent memory and thinking problems that sometimes happen after brain radiation for a brain tumor. You may qualify if you are under 18 when treated and had radiation within the last 7 years.
Solna, Stockholm CountyAges 5 years+ - NCT06088212Recruiting
Heart failure treatment to help thinking and memory
This trial tests whether better managing heart failure after a hospital stay can protect against thinking and memory problems. It is for people who have heart failure and have had some cognitive difficulties.
Hobart, TasmaniaAges 18 years+ - NCT05907343Recruiting
Closed-loop brain stimulation for memory changes
This study tests a type of brain stimulation that adjusts based on your brain signals to see if it can help with cognitive decline or mild memory problems. You may be able to join if you are cognitively normal, or if you have mild cognitive impairment (MCI), and your brain imaging and stimulation setup is possible.
Austin, TexasAges 18–90 - NCT03954899Recruiting
Melatonin test for brain health in older adults
This study tests whether taking 5 mg of melatonin can improve thinking and brain health over time in older adults with early, mild symptoms. You may help researchers learn which brain changes and measures improve with melatonin.
Iowa City, IowaAges 56–85 - NCT07511270Recruiting
Predicting thinking skills from speech using AI
This study uses an AI tool to analyze short stories you tell aloud, to see if it can predict your thinking and memory test scores. It may help develop a simpler way to check cognitive health.
TaoyuanAges 50 years+ - NCT07220694Recruiting
Sabroxy supplement for memory and insulin resistance
This study tests whether a supplement called Sabroxy can improve insulin resistance and memory in adults with mild cognitive impairment and insulin resistance. It may help if you have early memory problems and your blood sugar is slightly higher than normal.
San Francisco, CaliforniaAges 40–80 - NCT05088187Recruiting
Study of thinking and quality of life after thyroid surgery
This study looks at how thyroid surgery affects thinking (cognition) and day-to-day quality of life. It may help patients and doctors understand what to expect and how to support people after surgery.
StockholmAges 18 years+ - NCT06928298Recruiting
A cognitive screening study for Spanish speakers aged 60+
This study tests a new, easy-to-use cognitive screening tool on an iPad for older adults who speak Spanish. It aims to help primary care doctors detect thinking or memory changes early.
Austin, TexasAges 60 years+ - NCT07130669RecruitingPhase 1/Phase 2
Memory and thinking study for older adults
This trial tests a program to help maintain or improve memory and thinking skills in older adults. You may join if you are 60-89, speak English, and live at home or in an assisted-living facility.
Palo Alto, CaliforniaAges 60–89 - NCT07135336Recruiting
Cognitive decline after surgery in older adults with memory problems
This study looks at how surgery and anesthesia affect memory and thinking in older adults who already have mild memory problems. It compares patients having elective non-cardiac surgery with a similar group who are not having surgery, to see if the surgery itself causes more confusion or memory decline.
Shenzhen, GuangdongAges 60 years+ - NCT06793735Recruiting
Virtual reality app for memory and thinking problems
This trial tests a virtual reality app you can use at home to help with early memory or thinking problems. It may be an option if you have mild cognitive impairment or notice your thinking is slowing down.
Messina, ItalyAges 40–80 - NCT06411561Recruiting
Boosting memory after ICU stay for older adults
This study tests a combination of activities (like cognitive training and exercise) to help older adults recover thinking and memory after a serious illness in the ICU. It may help you regain sharpness and independence after leaving the intensive care unit.
Seattle, WashingtonAges 60 years+ - NCT07286448Recruiting
Digital Brain Training for Mild Memory Problems
This trial tests a personalized digital brain training program for people with mild memory or thinking problems. It aims to see if the training can boost cognitive fitness and help maintain your thinking skills.
Modena, Reggio Nell'Emilia (RE)Ages 50 years+
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Common questions
- Are there clinical trials for cognitive decline?
- Yes. Clin2 currently lists 181 recruiting cognitive decline studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive decline trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive decline trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.