Clinical trials
Cognitive Impairment clinical trials
Below are recruiting cognitive impairment clinical trials, each written for real people, not researchers. We’re tracking 571 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04556227Recruiting
Exercise and memory training after ICU delirium
This study tests whether combining gentle cycling while lying down with tablet-based memory exercises can improve recovery after ICU delirium. It may help people regain thinking and comfort after a hospital stay.
Kansas City, MissouriAges 45–64 - NCT05155137RecruitingPhase 3
Daily pill and home risk check to prevent stroke and memory loss
This Phase 3 trial tests whether a daily “polypill” plus a simple home risk-check plan can lower the chance of stroke and future thinking/memory problems. It is aimed at adults at moderate risk but who have not had stroke or heart disease before.
Porto Alegre, Rio Grande do SulAges 50–75 - NCT06889818Recruiting
Alzheimer's treatment and diagnostics registry study
This study creates a registry for people who are using newly approved Alzheimer's medications. It tracks how these treatments work over time and may help researchers learn more about diagnosing and treating Alzheimer's.
IncheonAges 19 years+ - NCT07236190RecruitingPhase 2
Testing NPC-1 for people with Alzheimer's signs
This study tests whether a medicine called NPC-1 can help people with mild memory or thinking problems or early-stage Alzheimer's. It looks at a blood marker to see if the treatment may slow down the disease.
Boston, MassachusettsAges 55 years+ - NCT07213700Recruiting
Alzheimer's disease long-term study
This study follows people with Alzheimer's disease over time to learn more about the condition and improve future care. It is an observational study, meaning participants receive their usual care while researchers collect information.
MelbourneAges 18 years+ - NCT07146373Recruiting
Breathing muscle training and thinking ability study
This trial tests whether training the muscles you use to breathe in can help improve thinking and memory. It's for people with mild to moderate cognitive changes who are on stable medication.
Aigáleo, AtticaAges 60–90 - NCT06604104Recruiting
Visual Frailty Study in Older Adults with AMD
This study looks at something called 'visual frailty' in older adults with advanced age-related macular degeneration (AMD). It aims to develop a tool to better understand how vision loss affects daily life and overall health in people aged 60 and over.
Edinburgh, ScotlandAges 60 years+ - NCT06180902Recruiting
Testing fluid response methods in patients with reduced consciousness
This trial compares different ways to check if a patient in the ICU with lowered consciousness needs more IV fluids. It aims to find the most accurate method, which could help doctors give the right amount of fluid.
MoscowAges 18 years+ - NCT07289061Recruiting
Positive psychology for early memory changes
This trial tests whether positive psychology exercises can help improve memory and brain function in people with very early memory changes. It may be a good fit if you have noticed new memory concerns or a mild cognitive impairment.
ThessalonikiAges Any age - NCT05565833RecruitingPhase 2
Online sleep program for insomnia and thinking problems
This Phase 2 study tests an internet-based sleep program to help older adults with insomnia and related thinking difficulties. It may help improve sleep and reduce how much tiredness and sleep disruption affect daily life.
Charlottesville, VirginiaAges 65 years+ - NCT07612449Recruiting
Percepta for Cognitive Optimization
This study tests whether Percepta, combined with wearable ring tracking, can help improve memory and thinking skills in people with mild cognitive concerns. You'll use an Oura Ring to track health data and complete app-based surveys to see if the treatment helps your cognitive function.
Wilmington, DelawareAges 40–85 - NCT07293494Recruiting
Spaceflight stress and brain changes study
This study looks at how the stress of spaceflight affects the brain and behavior. You will complete tasks and have MRI scans while staying in a controlled environment, including some sleep disruption and alcohol consumption.
Philadelphia, PennsylvaniaAges 21–60 - NCT07140744Recruiting
Blood test for early Alzheimer's detection in memory clinics
This study looks at whether a new blood test for Alzheimer's-related proteins (p-tau217) can help doctors diagnose memory problems earlier and more accurately. It is for people who have recently noticed cognitive issues but haven't yet been diagnosed or treated.
New York, New YorkAges 50 years+ - NCT07064226Recruiting
Digital cognitive rehab for older adults
This trial tests a digital program designed to help improve cognitive skills in older adults with mild memory or thinking problems. The program may help strengthen attention, memory, and problem-solving abilities.
MilanAges 65 years+ - NCT06995443Recruiting
Can light therapy help 'chemo brain' after breast cancer?
This study tests whether a special light therapy (photobiomodulation) can help improve the 'chemo brain' – memory and thinking problems – that some women experience after breast cancer chemotherapy. If you've had memory issues since chemo and finished treatment within the past year, you may be able to join.
ValenciennesAges Any age - NCT07002996Recruiting
Virtual reality memory training for mild cognitive impairment
This study tests whether a special memory training program using virtual reality can improve thinking skills in people with mild cognitive impairment. It may help slow memory loss and keep your mind sharper.
Verdun, QuebecAges 55 years+ - NCT06682741Enrolling by invitation
Comparing exercise programs for brain health in women
This study tests whether different types of exercise training can improve thinking and memory in women. It may help find the best workout for keeping your mind sharp.
Poznan, PolandAges 50 years+ - NCT06403345Recruiting
Green activity program for memory challenges
This study tests a green activity program for people with memory challenges. You and a friend or family member will take part in outdoor activities to see if they help with thinking and well-being.
Bloomington, IndianaAges 45 years+ - NCT05927974Recruiting
Brain mapping during surgery for hard-to-control epilepsy
This trial studies how the brain’s control networks work during a surgery-related procedure for people with epilepsy that hasn’t improved with usual treatments. If you qualify, you may do specific tasks while the team maps and measures brain activity to better understand and guide care.
Birmingham, AlabamaAges 18 years+ - NCT05907343Recruiting
Brain stimulation study for memory and thinking concerns
This study tests a new brain stimulation method that may help improve memory and thinking in older adults who have memory concerns. It uses a safe, non-invasive technique called transcranial magnetic stimulation (TMS) that sends magnetic pulses to the brain.
Austin, TexasAges 18–90 - NCT05500170Recruiting
Study of nicotinamide riboside for sleep and thinking
This trial tests whether nicotinamide riboside can improve sleep quality and help with thinking and memory. You may be invited if your sleep is poor and you do not show signs of dementia on a brief mental test.
Buffalo, New YorkAges 65–85 - NCT05375513Recruiting
Home-based program to boost memory and thinking
This study tests a program that combines exercise, diet advice, and memory training, all done from home, to help improve thinking and memory in older adults with mild memory problems. You'll be asked to use a computer or tablet for virtual sessions and follow a simple plan.
Edmonton, AlbertaAges 60–85 - NCT07594665Enrolling by invitation
Home-based cognitive health blood tests for older adults
This study invites people aged 65+ who are already part of the SHUTi MIND research program to do simple blood tests at home to check for early signs of cognitive changes. The goal is to make it easier for people to access brain-health testing without going to a clinic.
Charlottesville, VirginiaAges 65 years+ - NCT05149742Recruiting
Study of hearing loss and thinking skills in midlife adults
This study looks at how severe hearing loss affects thinking and memory in adults aged 45–64. Researchers will compare people with significant hearing loss to people with normal hearing who are similar in age, sex, and education.
ParisAges 45–64
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Common questions
- Are there clinical trials for cognitive impairment?
- Yes. Clin2 currently lists 571 recruiting cognitive impairment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive impairment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive impairment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.