Clinical trials
Cognitive Impairment clinical trials
Below are recruiting cognitive impairment clinical trials, each written for real people, not researchers. We’re tracking 575 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07372066Recruiting
Brain exercise group for seniors with memory concerns
This trial tests a cognitive stimulation therapy group for older adults living in residential homes who have mild cognitive impairment or dementia. The goal is to see if group activities can help keep the mind active and improve quality of life.
Hong Kong, Hong KongAges 60 years+ - NCT06727773RecruitingPhase 2
Memantine and exercise to protect thinking during chemo for breast cancer
This study tests whether a medicine called memantine combined with a structured exercise program can help protect your thinking and memory during chemotherapy for breast cancer. It may also help understand how these treatments work in the body.
Chapel Hill, North CarolinaAges 18 years+ - NCT03657745Recruiting
40 Hz light and brain training for Alzheimer’s
This trial tests whether a combination of 40 Hz light stimulation and cognitive (thinking) therapy can improve symptoms in people with Alzheimer’s disease. It may help by stimulating the brain and training thinking skills, while carefully checking eye and seizure history.
Miami, FloridaAges 50 years+ - NCT05903573Recruiting
Artificial intelligence training for memory and thinking changes
This study tests whether a new computer-based training program (guided by artificial intelligence) can improve memory and thinking in people who report recent cognitive changes. You’ll be randomly assigned to training or an education/control group and complete testing before and after the program.
Gainesville, FloridaAges 55–100 - NCT07169630RecruitingPhase 1
PET scan study for Alzheimer's or mild cognitive impairment
This study uses a special PET scan to look at a brain protein called PDE4 in people with Alzheimer's disease or mild cognitive impairment. It may help researchers understand how this protein is involved in memory and thinking problems.
Bethesda, MarylandAges 50–100 - NCT05250349Recruiting
Ultrasound brain blood flow and thinking in stable heart failure
This trial studies whether a noninvasive ultrasound test of blood flow in the brain, along with memory and thinking questionnaires, can help explain thinking changes in people with stable heart failure. It may help researchers better understand why some people develop cognitive (thinking) difficulties as heart failure progresses.
Krakow, MPAges 18 years+ - NCT06179680Recruiting
White matter changes in memory problems or Alzheimer's
This study uses brain MRI scans to look at white matter changes in people with memory problems (amnestic mild cognitive impairment) or Alzheimer's disease. It aims to understand how these changes relate to memory loss.
San Donato Milanese, MilanoAges 65 years+ - NCT06984367Recruiting
Tech and social support for mild memory problems
This trial tests a program that uses technology and community support to help people with mild cognitive impairment stay independent. It may improve memory and daily function.
AnconaAges 65 years+ - NCT07145294RecruitingPhase 1/Phase 2
Stem cell therapy to improve thinking after stroke
This trial tests whether tiny particles from stem cells can help people recover thinking and memory after a recent stroke. Doctors will check if the treatment is safe and if it boosts brain function.
ShanghaiAges 18 years+ - NCT07402161Recruiting
Finding Alzheimer's earliest signature in memory concerns
This study looks for early signs of Alzheimer's in people who feel their memory is slipping but still function normally. You'll help researchers find a pattern—a 'signature'—in the brain that may signal the earliest stages of the disease.
San Donato Milanese, MilanAges 18 years+ - NCT05014893Recruiting
Brain testing and rehab study for thinking changes
This study looks at how brain activity relates to thinking problems and whether a cognitive (thinking) assessment and rehab approach can help adults with memory or thinking changes. You may be asked to take thinking tests and complete study activities during rehab.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05881239Recruiting
Remote smell tests to track early Alzheimer’s health changes
This trial uses remote, at-home (or remote) smell-based testing to help researchers assess health in people with preclinical Alzheimer’s disease and in control participants. It may help by showing how well smell-related changes can signal disease status over time.
Boston, MassachusettsAges 18–100 - NCT06201533Recruiting
Light exercise and thinking activities for memory
This study tests if a program that combines light physical activity with simple mental tasks can help improve memory and thinking in people with mild cognitive impairment (MCI). It is for people who are not already exercising regularly and do not take memory medications.
Chiang MaiAges 60 years+ - NCT06754202Recruiting
Farming and nature activities for mild memory loss
This study tests if spending time in farmlands and natural settings can help older adults with mild memory problems maintain their thinking abilities and overall health. It uses a special approach based on the Montessori method to keep participants engaged and active.
AnconaAges 55 years+ - NCT06584357Recruiting
Digital and blood markers linked to brain scans in older adults
This study is looking for older adults (60–90) who are either cognitively normal, have mild cognitive impairment (MCI), or have mild-to-moderate Alzheimer's dementia. It aims to see how digital tests and blood-based markers relate to brain scans (amyloid and tau PET). You will need a study partner, undergo MRI and PET scans, and give blood samples.
Atlantis, FloridaAges 60–90 - NCT06650969Recruiting
Early detection of cognitive decline in type 2 diabetes
This study is looking at ways to catch early thinking and memory changes in people with type 2 diabetes. By joining, you may help doctors learn how to spot problems sooner and find better ways to help.
Nanjing, JiangsuAges 45 years+ - NCT05372172Recruiting
Tennessee Alzheimer’s study for people 60 and older
This study is looking at how brain and memory changes show up in people across the Alzheimer’s spectrum—from normal thinking to mild memory problems to Alzheimer’s disease. You might join if you can do study visits and an MRI and have a reliable study partner available.
Nashville, TennesseeAges 60 years+ - NCT04635657Recruiting
Testing brain function after meningioma surgery
This study measures how thinking and memory change after surgery to remove a meningioma near the front or side of the brain. It may help doctors better understand what to expect and how cognitive recovery can differ from person to person.
Columbus, OhioAges 18–89 - NCT07239310Recruiting
Device to improve memory and thinking in early Alzheimer's
This study tests a device called Neuclare that aims to temporarily boost memory and thinking skills in people with mild cognitive impairment or very early Alzheimer's disease. It could offer a non-drug way to help with daily mental tasks.
Cheonan, Chungcheongnam-doAges 55–90 - NCT06733714Recruiting
Brain stimulation plus memory training for older adults
This study tests whether a gentle, non-invasive electrical current applied to the scalp (tACS) combined with computer-based brain exercises can improve memory and thinking in older adults who have concerns about their cognitive health.
Rio de Janeiro, Rio de JaneiroAges 50 years+ - NCT06528379Recruiting
Physical activity to prevent thinking decline in older adults
This study tests whether a physical activity program can help prevent memory loss and disability in older Greek adults who have noticed some decline in their thinking. You can join if you have mild memory concerns but no dementia and are healthy enough to be active.
Pátrai, AchaiaAges 50 years+ - NCT06484244Recruiting
Walking and balance in memory loss
This study looks at how older adults with mild cognitive impairment or Alzheimer's disease adapt their walking. It aims to understand walking and balance to help people stay mobile and safe longer.
Atlanta, GeorgiaAges 50–90 - NCT07452939Recruiting
Brain stimulation to help memory after ICU delirium
This study tests if a noninvasive brain stimulation technique called theta burst stimulation can improve thinking and memory problems that can happen after a stay in the ICU with delirium. It may help people who are still having cognitive issues a few months after leaving the hospital.
Gainesville, FloridaAges 50–75 - NCT07512362RecruitingPhase 2
Stem cells and antibodies for early Alzheimer's disease
This study tests whether human stem cells, combined with your existing Alzheimer's medication (Leqembi or Kisunla), can help slow memory loss and improve daily functioning in people with mild cognitive impairment or early Alzheimer's. You would receive a stem cell infusion as an add-on to your current treatment.
Miami, FloridaAges 55–90
Hear when a new Cognitive Impairment trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for cognitive impairment?
- Yes. Clin2 currently lists 575 recruiting cognitive impairment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive impairment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive impairment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.