Clinical trials
Cognitive Impairment clinical trials
Below are recruiting cognitive impairment clinical trials, each written for real people, not researchers. We’re tracking 571 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07250789Recruiting
Brain Care Study: Screen and help for thinking decline in type 2 diabetes
This study screens older adults with type 2 diabetes for early signs of memory or thinking problems, and offers a program to help keep the brain healthy. It aims to find out if a combination of lifestyle changes, mental exercises, and medical support can slow cognitive decline.
CopenhagenAges 65 years+ - NCT03860857RecruitingPhase 3
Study biomarkers in memory aging and brain health
This Phase 3 study looks for blood/brain “biomarkers” linked to aging, memory changes, and early brain degeneration. It may help researchers better identify who is at risk and how biology relates to thinking and memory, using brain scans and thinking tests.
Irvine, CaliforniaAges 60 years+ - NCT07718321Recruiting
StimolIrpinia for brain injury rehab: a feasibility trial
This trial tests a new cognitive rehab tool called StimolIrpinia for people recovering from a serious brain injury. It aims to see if the tool is acceptable and helpful for improving thinking and memory.
Sant'Angelo dei Lombardi, AVAges 18–75 - NCT05954741Recruiting
Rehab program to improve thinking in recent vascular memory problems
This trial tests a structured, multi-part rehabilitation program to help people with early dementia symptoms from vascular or mixed causes. If you qualify, you may be offered the rehab program and compared with another approach to see if thinking and daily function improve.
Montescano, PaviaAges 65–80 - NCT07083154RecruitingPhase 3
Mazdutide for type 2 diabetes with early memory problems
This study tests a new medication, Mazdutide, to see if it can slow or improve memory and thinking problems in people with type 2 diabetes and early-stage cognitive impairment. It may help by targeting blood sugar control and possibly reducing the impact of diabetes on brain function.
Changsha, HunanAges 50–75 - NCT06852209Recruiting
Brain training with neurofeedback after a stroke
This study tests a brain-training technique called neurofeedback to see if it can improve thinking skills after a stroke. If you have ongoing memory or attention problems despite recovery, this trial may help you train your brain using real-time feedback from your own brain activity.
BordeauxAges 18–75 - NCT07680517Recruiting
Short PTSD treatment for military personnel
This study tests if a short, intensive PTSD treatment can help reduce psychological and cognitive symptoms. It is for current military personnel with PTSD or symptoms that are close to meeting the full diagnosis.
Fayetteville, North CarolinaAges 18 years+ - NCT07547319Recruiting
Accelerated rTMS to improve cognitive function
This study tests whether repeated magnetic pulses to the brain (called rTMS) can help improve thinking and memory in older adults with mild to moderate cognitive decline. The treatment is non-invasive and may help slow cognitive changes.
San Francisco, CaliforniaAges 50–90 - NCT07130669RecruitingPhase 1/Phase 2
Memory and thinking study for older adults
This trial tests a program to help maintain or improve memory and thinking skills in older adults. You may join if you are 60-89, speak English, and live at home or in an assisted-living facility.
Palo Alto, CaliforniaAges 60–89 - NCT05114876Recruiting
Tested a new plan to support older adults after surgery
This study looks at a redesigned surgical care plan to better support older adults who may have memory or thinking changes after major planned surgery. If you qualify, you would be assessed before surgery and followed after to see whether this approach helps.
Toronto, OntarioAges 60 years+ - NCT07402356Recruiting
Virtual reality eye test for thinking problems
This study uses virtual reality and eye-tracking (pupillometry) to measure thinking and memory problems in people with Alzheimer's, mild cognitive impairment, or depression. It aims to find better ways to detect and track cognitive changes using a simple, non-invasive procedure.
München, BavariaAges 18–80 - NCT07193277RecruitingPhase 4
Butylphthalide for thinking problems in older adults with epilepsy
This study tests whether a medicine called butylphthalide can help improve memory and thinking in older adults with focal epilepsy who already have mild cognitive issues. It aims to find a new way to support brain health in people with epilepsy.
Wenzhou, ZhejiangAges 60–85 - NCT05968703Recruiting
Deep brain stimulation study for mild memory trouble in Parkinson’s
This trial looks at a specific type of deep brain stimulation (DBS) to see if it can help people with Parkinson’s who have mild cognitive problems (mild memory/thinking changes). You may also be asked to temporarily stop Parkinson’s medications around research visits to measure effects more clearly.
Stanford, CaliforniaAges 21–80 - NCT06095297Recruiting
Cognitive rehab for brain fog from long COVID
This study tests a computer-based cognitive training program combined with a gentle nerve stimulation device to see if it can improve brain fog and daily functioning in people with long COVID. If you're struggling with thinking, memory, or concentration after COVID, this might help.
Birmingham, AlabamaAges 18 years+ - NCT04153838Enrolling by invitation
Track thinking skills in children over time
This study follows children’s thinking and learning over time using simple testing at school. It aims to better estimate how children’s thinking develops and how it changes as they grow.
Aberdeen, UKAges 6–17 - NCT03954899Recruiting
Melatonin test for brain health in older adults
This study tests whether taking 5 mg of melatonin can improve thinking and brain health over time in older adults with early, mild symptoms. You may help researchers learn which brain changes and measures improve with melatonin.
Iowa City, IowaAges 56–85 - NCT04184375Recruiting
Memory training for older adults with bipolar disorder
This study tests whether structured memory and thinking exercises (cognitive stimulation) help older adults with bipolar disorder who have mild to moderate thinking and memory problems. You may be offered guided sessions designed to improve everyday thinking skills while checking safety and fit for the program.
La RochelleAges 65 years+ - NCT04360200Recruiting
Study of thinking changes in older adults
This trial looks at people over age 50 who have mild thinking or memory problems but do not have dementia by standard clinical criteria. It tests how these early changes are characterized and measured using exams such as blood tests and brain scans, which may help improve understanding and future care.
Guangzhou, GuangdongAges 50 years+ - NCT05840575Recruiting
Study of thinking changes in young people during cancer treatment
This study looks at how thinking and memory may change in children and young adults after a new cancer diagnosis, especially around chemotherapy. It may help doctors better understand and track brain-related side effects early.
CopenhagenAges 7–29 - NCT07027072RecruitingPhase 2
Testing KDS2010 for early Alzheimer's memory loss
This study tests a new drug called KDS2010 for people with early Alzheimer's or mild memory loss. It aims to see if the drug can slow thinking and memory decline. You will need a caregiver to help with visits and must have a special brain scan showing amyloid plaques.
Gwangju, GwangjuAges 50–85 - NCT06983769Recruiting
CPAP vs Mouthpiece for Sleep Apnea in Patients with Memory Issues
This study compares two treatments for sleep apnea (CPAP and a custom mouthpiece) to see which is better for patients who also have mild memory or thinking problems. Sleep apnea is a condition where breathing stops and starts during sleep. You may qualify if you have moderate-to-severe sleep apnea and mild cognitive impairment.
Kent Ridge, Please SelectAges 45 years+ - NCT06579664Recruiting
Brain stimulation for memory loss from small vessel disease
This trial tests whether a type of non-invasive brain stimulation called intermittent theta burst stimulation can improve memory and thinking in people whose cognitive problems are caused by cerebral small vessel disease (damage to the small blood vessels in the brain). You may qualify if you have mild memory or thinking issues that have lasted at least three months.
BeijingAges 45–80 - NCT03665831Recruiting
Deep TMS for depression and memory problems in older adults
This study tests a type of brain stimulation called Deep TMS to help reduce depression and improve or stabilize memory-related symptoms in older adults with Alzheimer’s disease. It’s mainly for people whose depression did not improve or could not be tolerated with antidepressant medicine.
Toronto, OntarioAges 60 years+ - NCT04520139RecruitingPhase 1/Phase 2
NAC to help prevent chemo brain fog in ovarian cancer
This Phase 1/2 study tests whether taking NAC (a supplement medicine) can help prevent or reduce memory and thinking problems after platinum chemotherapy. It targets people with advanced ovarian, fallopian tube, or primary peritoneal cancer who are starting at least six cycles of platinum-based treatment.
Orange, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for cognitive impairment?
- Yes. Clin2 currently lists 571 recruiting cognitive impairment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive impairment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive impairment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.