Clinical trials
Colorectal cancer clinical trials
Cancer of the colon or rectum, often beginning as small growths called polyps. We’re tracking 1,061 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05319314RecruitingPhase 1/Phase 2
Study drug for advanced colon cancer that has come back or failed
This Phase 1/2 trial tests LYL273, a new targeted treatment, for people with metastatic colorectal (colon) cancer that has returned or not responded to standard chemo. It’s designed to see how well the drug can control the cancer and what side effects it causes.
Duarte, CaliforniaAges 18 years+ - NCT05355363Recruiting
Check what happens after missed colon follow-up for colon polyps
This study looks at the risk of new or advanced colon findings in people who had certain colon polyp results, but then did not get the recommended follow-up colonoscopy on time. It may help doctors fine-tune how urgently different patients need repeat colon checks.
Montreal, QuebecAges 45–80 - NCT05404230Recruiting
Preventing nerve damage from oxaliplatin in the hands and feet
This study looks at ways to prevent numbness or nerve pain in the hands and feet that can happen from oxaliplatin treatment. It includes people with colon or rectal cancer who will be getting standard chemotherapy with capecitabine plus oxaliplatin.
AalborgAges 18 years+ - NCT05491434Recruiting
Study of muscle loss in colon cancer patients
This trial looks at muscle loss (called sarcopenia) in people with colon cancer to test an intervention that may help strength or recovery. If you’re age 70 or older and meet the cancer and health requirements, you may be able to take part.
L'Hospitalet de Llobregat, BarcelonaAges 70 years+ - NCT05501353Recruiting
Study tumor biomarkers in recurrent metastatic colon cancer
This study looks for blood/tumor signals (“biomarkers”) that may help predict outcomes in people whose colorectal cancer returns and spreads after surgery. It mainly helps researchers understand who may do better or worse, which can guide future care.
Hangzhou, ZhejiangAges 18–99 - NCT05536089Recruiting
Testing blood methylation to predict colorectal cancer relapse
This trial checks a blood test for “ctDNA methylation” to see who may be at higher risk of colorectal cancer returning after surgery. It may help doctors better judge whether adjuvant chemotherapy is working or needed.
Hangzhou, ZhejiangAges 18 years+ - NCT05704413Recruiting
Biobank study using gut tissue in bowel disease
This study collects and stores digestive (bowel) tissue to better understand how gut bacteria may affect diseases like ulcerative colitis or Crohn’s disease. It may help researchers find future ways to improve care for people with these conditions.
ParisAges 18 years+ - NCT05748145RecruitingPhase 2
Metronidazole before colon cancer surgery to reduce recurrence risk
This Phase 2 study tests whether taking metronidazole, an antibiotic, before surgery for colorectal cancer can improve outcomes. Participants take it before their planned operation, and doctors study the cancer tissue and related markers to see if it helps.
Bellinzona, Canton TicinoAges 18 years+ - NCT05768503RecruitingPhase 3
Test new drugs after colorectal cancer chemotherapy
This Phase 3 trial compares a new treatment combination (chidamide plus sintilimab plus bevacizumab) versus the standard second-line chemotherapy (FOLFIRI plus bevacizumab) for advanced colorectal cancer that is microsatellite stable/low. It aims to see which treatment works better and is safer for people whose cancer grew after first-line oxaliplatin-based therapy.
Hefei, AnhuiAges 18–75 - NCT05787197Recruiting
Blood test to guide treatment after colon cancer liver surgery
This trial studies a blood test (called ctDNA) in people with colon cancer that has spread to the liver and is being removed with curative surgery. The goal is to see how the blood test can help with planning and improving treatment after surgery.
BesançonAges 18 years+ - NCT05789433Recruiting
Aerobic exercise study after colon or rectal cancer surgery
This trial studies whether a supervised aerobic exercise program helps muscles “remodel” (change/strengthen) after colon or rectal cancer treatment. It may help people improve physical function during recovery, but you can only join if it’s safe for you and you can follow the study plan.
Orlando, FloridaAges 18 years+ - NCT05903885Recruiting
Colorectal cancer screening help for Black adults in Nebraska
This study looks at how to improve colorectal cancer prevention and health equity for Black or African American adults. You may be invited because you may be due for colorectal cancer screening based on age and screening history.
Omaha, NebraskaAges 45–75 - NCT05913674RecruitingPhase 2
Feasibility of modified chemotherapy after bowel surgery
This Phase 2 study tests whether a modified chemotherapy given inside the abdomen soon after surgery is practical and safe. It may help people with appendix or colon cancer that has spread within the abdomen (peritoneal carcinomatosis) by targeting cancer cells after tumor removal.
Montreal, QuebecAges 18 years+ - NCT05961969Recruiting
Robotic rectal surgery for early-to-mid rectal cancer
This trial tests a robotic, top-down approach to remove certain rectal tumors using an intersphincteric resection (a surgery that preserves bowel control as much as possible). It may help some people with stage I–III rectal cancer avoid a bigger operation and improve outcomes compared with standard surgical methods.
TaipeiAges 20–75 - NCT05963191Recruiting
Test camera bowel scan for early Lynch syndrome lesions
This study tests a special CAD-EYE system to help detect abnormal (potentially cancer-related) growths during colonoscopy in people with Lynch syndrome. It may improve how reliably clinicians find lesions early, when treatment can be easier.
ParisAges 18–90 - NCT05970705RecruitingPhase 2
Regorafenib plus TAS-102 versus regorafenib alone for advanced bowel cancer
This Phase 2 study tests whether adding TAS-102 to regorafenib works better than regorafenib by itself for metastatic colorectal cancer after at least one prior treatment has stopped working. It aims to improve how long the cancer can be controlled for patients in later treatment lines.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05994482Recruiting
Surveillance colonoscopy study in older veterans
This study looks at how often older veterans (age 75 and older) should get a follow-up colonoscopy after having polyps removed. Researchers will review medical records and talk to patients and doctors to help create better guidelines for surveillance colonoscopies in older adults.
San Diego, CaliforniaAges 75 years+ - NCT05999370Recruiting
Pre-surgery exercise and nutrition for older colorectal cancer patients
This trial tests whether exercise and nutrition support before surgery can help older colorectal cancer patients who are weak or malnourished. If you are 65 or older, scheduled for colorectal cancer surgery, and have trouble walking or eating well, this study may be for you.
Montreal, QuebecAges 65 years+ - NCT06059963Recruiting
Simple blood test for colorectal cancer screening
This study is testing a new blood test (Signal-C) to see if it can help find colorectal cancer early. You may be able to join if you are average risk and getting a routine screening colonoscopy.
Raonoke, VirginiaAges 45–84 - NCT06077591Recruiting
Genetic and organoid testing to guide cancer treatment
This trial uses advanced testing (genetic sequencing and lab-grown tumor models) to find the best treatment for people with advanced solid tumors that haven't responded to at least one standard treatment. The goal is to personalize therapy based on your tumor's unique features.
Hong Kong, N.T.Ages 18–100 - NCT06168786RecruitingPhase 2
New drug combo and radiation for advanced colorectal cancer
This trial tests a new combination of drugs (cadonilimab, fruquintinib) plus targeted radiation (SBRT) for people with advanced MSS colorectal cancer who have already tried several standard treatments. The goal is to see if this combination can help shrink tumors or slow disease progression.
Wuhan, HubeiAges 18–75 - NCT06280495RecruitingPhase 2/Phase 3
Targeted drugs plus chemo before surgery for colon cancer with liver spread
This trial tests whether adding two targeted drugs (serplulimab and bevacizumab) to standard chemotherapy before surgery can improve outcomes for people with colorectal cancer that has spread to the liver. It is for those whose cancer has certain genetic features and is considered resectable.
Guangzhou, GuangdongAges 18–75 - NCT05785780Enrolling by invitation
Help improve colon cancer screening for people with diabetes
This study looks for better ways to make sure people with diabetes get up-to-date colon cancer screening. If you haven’t had the recommended test on time, it may help identify barriers in primary care and improve screening follow-through.
New Brunswick, New JerseyAges 50–74 - NCT06402188Recruiting
ColoSeal Device Study for Rectal Cancer Surgery
This study tests a new device called the ColoSeal ICD System that may help protect the reconnection of your bowel after surgery for rectosigmoid or rectal cancer. It is designed for people who are already scheduled for surgery that includes a temporary colostomy or ileostomy.
YerevanAges 18–70
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Common questions
- Are there clinical trials for colorectal cancer?
- Yes. Clin2 currently lists 1,061 recruiting colorectal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.