Clinical trials
Colorectal cancer clinical trials
Cancer of the colon or rectum, often beginning as small growths called polyps. We’re tracking 1,061 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06407518Recruiting
Preoperative medicine for pain relief in colorectal cancer patients with sleep or anxiety issues
This trial tests whether taking a medicine called midazolam before surgery can help with pain after surgery in people with colorectal cancer who have trouble sleeping or feel anxious. You would receive the medicine as a drink before your operation.
Guangzhou, GuangdongAges 18–60 - NCT06411600RecruitingPhase 2
Combination therapy for BRAF-mutated colorectal cancer
This trial tests a combination of targeted therapies for people with metastatic colorectal cancer that has a specific BRAF V600E mutation and has progressed after initial treatment. The goal is to see if this combination can shrink tumors or stop them from growing further.
BarcelonaAges 18 years+ - NCT06443307Recruiting
Study of Liposomal Irinotecan in Advanced Colorectal Cancer
This study tests a new form of chemotherapy called liposomal irinotecan (Nal-IRI) for people with advanced colorectal cancer or other solid tumors. The goal is to see how well it works and how safe it is in real-world settings.
Beijing, Beijing MunicipalityAges Any age - NCT06447961Recruiting
Psychological impacts of living with inherited colorectal cancer risk
This study explores how people feel emotionally and mentally when they have a genetic condition that raises their risk of colorectal cancer. It aims to understand the psychological effects, which could help improve support for others in the future.
LondonAges 18–99 - NCT06456515Recruiting
Regorafenib, sintilimab, and electroacupuncture for advanced colorectal cancer
This trial tests a combination of two drugs (regorafenib and sintilimab) plus electroacupuncture for people with advanced colorectal cancer that hasn't responded to standard treatments. The goal is to see if this triple therapy can help shrink tumors or slow the cancer's growth.
ChangzhouAges 18–75 - NCT06485713RecruitingPhase 2
Third-line therapy for advanced colorectal cancer
This trial tests a combination of two oral cancer drugs, trifluridine/tipiracil and fufuquitinib, as a third-line treatment for people with advanced colorectal cancer. It may be an option if prior treatments have stopped working.
Wenzhou, ZhejiangAges 18–75 - NCT06515821Recruiting
Improving colorectal cancer screening and diagnosis
This study collects data to improve how colorectal cancer is found and diagnosed. It compares new testing methods (like breath and stool tests) with standard colonoscopy in people with and without cancer or risk factors.
SofiaAges 18 years+ - NCT06516445RecruitingPhase 2
Short radiation plus targeted drugs before surgery for rectal cancer
This trial tests a new combination of treatments before surgery for locally advanced rectal cancer. You would receive short-course radiation, then an immunotherapy drug (camrelizumab) plus a PARP inhibitor (fluzoparib) and chemotherapy, to shrink the tumor and make surgery more successful.
Wuhan, HubeiAges 18–75 - NCT06542835Recruiting
Telehealth support for colorectal cancer screening
This study tests whether telehealth support can help people get recommended colorectal cancer screening. It may be a good fit if you haven't been screened recently and are willing to use your phone for health guidance.
Los Angeles, CaliforniaAges 45–64 - NCT06551207Recruiting
New drug combo with radiation for advanced MSS colon cancer
This trial tests a new combination—an immunotherapy drug (cadonilimab) plus a targeted anti-angiogenesis pill (fruquintinib) and focused radiation (SBRT)—for people with MSS colorectal cancer that has progressed after at least two prior treatments. The goal is to see if this triple approach can help shrink or control the cancer better than standard options.
Wuhan, HubeiAges 18–75 - NCT06558773RecruitingPhase 2
New drug combo for previously treated colorectal cancer
This trial tests a combination of a GSL synthesis inhibitor, an immunotherapy drug, and/or regorafenib in people with a specific type of colorectal cancer (pMMR/MSS) that has not responded to at least two prior treatments. The goal is to see if this new approach can help shrink or control the cancer.
Beijing, Biotherapeutic Department of Chinsese PLA Gereral HospitalAges 18–75 - NCT06598007RecruitingPhase 1/Phase 2
Studying CT3001 for advanced solid tumors
This study tests an experimental drug called CT3001 for people with advanced solid tumors that haven't responded to other treatments. The goal is to see if it's safe and effective, and for some patients with colorectal cancer, it may be combined with standard chemotherapy.
Houston, TexasAges 18 years+ - NCT06621173RecruitingEarly Phase 1
Gene therapy for advanced colorectal cancer (dMMR/MSI-H)
This trial tests a new gene therapy (HNF4α SrRNA) given through a vein for people with advanced colorectal cancer that has a specific genetic marker (dMMR or MSI-H). It's for those who have already tried standard treatments without success or couldn't take them.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06645236Recruiting
Testing for a specific KRAS mutation in tumor tissue
This study tests your tumor tissue for a specific change in the KRAS gene called G12C. Finding this mutation may help guide treatment options for certain cancers.
Manchester, ManchesterAges 18 years+ - NCT07224841Recruiting
Blood test to predict targeted therapy response in colorectal cancer
This study is developing a blood test that looks at DNA signals to see if certain targeted therapies will work for people with metastatic colorectal cancer. It may help doctors choose the right treatment in the future.
Duarte, CaliforniaAges 18 years+ - NCT06710067Recruiting
Urine chemicals for diagnosing disease
This study looks at chemicals in urine to help find new ways to diagnose diseases. You give one urine sample and answer a few questions—no treatment or long-term follow-up needed.
Encinitas, CaliforniaAges 18 years+ - NCT06720987RecruitingPhase 1
KQB365 for advanced solid tumors with KRAS mutations
This trial tests a new drug called KQB365, alone or with other drugs, for people with advanced solid tumors that have a specific KRAS mutation (G12C or G12S). It aims to see if the treatment is safe and effective.
Phoenix, ArizonaAges 18 years+ - NCT06751914Recruiting
Vaccine plus standard therapy for advanced colorectal cancer
This trial tests a personalized vaccine made from your tumor's unique markers, combined with standard second-line treatment, for colorectal cancer that has grown after first treatment. It aims to see if this combination can help control the cancer better.
Nanchang, JiangxiAges 18–70 - NCT06751940Recruiting
Personalized vaccine plus standard therapy for advanced colorectal cancer
This trial tests a personalized vaccine made from your tumor's unique features, combined with a standard second-line treatment, for colorectal cancer that has worsened after the first treatment. The goal is to see if this combination can help control the cancer better than standard therapy alone.
Nanchang, JiangxiAges 18–70 - NCT06751953Recruiting
Neoantigen vaccine plus standard third-line therapy for colorectal cancer
This study tests a vaccine made from your tumor's unique proteins (neoantigens) combined with a standard third-line therapy for colorectal cancer that has worsened after two previous treatments. The goal is to see if this combination helps control the cancer better.
Nanchang, JiangxiAges 18–70 - NCT06751966Recruiting
Peptide vaccine plus standard therapy for advanced colorectal cancer
This trial tests a personalized peptide vaccine (based on your tumor's unique markers) combined with standard third-line therapy for colorectal cancer that has progressed after two prior treatments. The goal is to see if adding the vaccine can help control the cancer better.
Nanchang, JiangxiAges 18–70 - NCT06791512RecruitingPhase 3
Chemo Plus Targeted Therapy With or Without Immunotherapy for Colorectal Cancer
This trial compares a standard chemotherapy combination (mFOLFOX6) plus a targeted drug (bevacizumab) with or without an immunotherapy (PD-1 antibody) for locally advanced colorectal cancer. It aims to see if adding the immunotherapy improves outcomes for patients with a specific tumor type (pMMR/MSS).
Guangzhou, GuangdongAges 18–80 - NCT06808685Recruiting
Study of Elovie for advanced colorectal cancer
This study looks at how well a biosimilar version of bevacizumab (Elovie) works in people with advanced colorectal cancer that has spread and cannot be surgically removed. It aims to see if Elovie is safe and effective when used as the first treatment for this cancer.
Vitória, Espírito SantoAges 18 years+ - NCT06815406Recruiting
Removing large colon polyps: one piece vs. multiple pieces
This trial compares two ways to remove large, flat polyps (granular type) from the colon or rectum: one that removes the polyp in one piece (endoscopic submucosal dissection) and one that removes it in pieces (endoscopic mucosal resection). The goal is to see which method has a lower chance of the polyp coming back.
BolognaAges 18 years+
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Common questions
- Are there clinical trials for colorectal cancer?
- Yes. Clin2 currently lists 1,061 recruiting colorectal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.