Clinical trials
Colorectal cancer clinical trials
Cancer of the colon or rectum, often beginning as small growths called polyps. We’re tracking 1,068 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05571644RecruitingPhase 2
Study compares two pre-surgery treatments for locally advanced rectal cancer
This Phase 2 trial tests whether a newer combination chemotherapy plus an immunotherapy medicine (cadonilimab/AK104) works better than standard chemotherapy before surgery for locally advanced colorectal cancer. The goal is to shrink the tumor and improve how well treatment works after surgery.
Guangzhou, GuangdongAges 18–70 - NCT06780423Recruiting
Muscle changes in colorectal cancer cachexia
This study compares muscle changes in people with colorectal cancer who have experienced weight loss (cachexia), those with colorectal cancer without weight loss, and healthy volunteers. Participants will have their trunk and leg muscles examined to understand how cachexia affects the body.
Diepenbeek, LimburgAges 18 years+ - NCT06764680RecruitingPhase 2
Oral drugs and radiation for advanced colorectal cancer after standard therapy
This trial tests a combination of oral chemotherapy, targeted therapy, and immunotherapy, with or without radiation, for people with advanced colorectal cancer that hasn't responded to at least two prior treatments. The goal is to see if this approach can help shrink tumors or slow the disease.
Guangzhou, GuangdongAges 18 years+ - NCT06753903Recruiting
Photon counting CT for liver metastasis from colorectal cancer
This trial tests a new type of CT scanner (photon counting CT) to see if it can better find liver spread from colorectal cancer. If you have colorectal cancer and need a liver check, this might help improve detection.
MilanAges 18–100 - NCT06441565RecruitingPhase 2/Phase 3
Fruquintinib with or without liver-directed chemo for advanced colorectal cancer
This trial tests a drug called fruquintinib, given alone or with a chemotherapy infusion directly into your liver, for people whose colorectal cancer has spread to the liver and has stopped responding to standard treatments. It aims to find a new option for patients with limited cancer outside the liver.
Guangzhou, GuangdongAges 18–75 - NCT06200831Recruiting
Same surgery or two surgeries for colorectal cancer with liver spread
This trial compares having one surgery to remove both the colon tumor and liver tumors at the same time versus having two separate surgeries. It aims to find which approach is safer and works better for patients whose cancer has spread only to the liver.
OsloAges 18–80 - NCT06741293Recruiting
Improving colorectal cancer early screening with stool tests
This study looks for markers in stool (poop) to detect colorectal cancer early. If you are between 40 and 74, live in the Lisbon area, and don't have certain digestive or cancer conditions, you may help improve screening by providing a stool sample.
Lisbon, Lisbon DistrictAges 40–74 - NCT06728072RecruitingPhase 2
Adding antibiotics to first chemo for advanced colorectal cancer
This trial tests whether adding a short course of antibiotics to your standard first chemotherapy for stage 4 colorectal cancer can improve treatment. The antibiotics target certain gut bacteria that might affect how well the chemo works.
Richmond, VirginiaAges 18 years+ - NCT06734156Recruiting
Gut microbiome study in colorectal cancer patients
This study looks at how bacteria and other microbes in your gut are linked to colorectal cancer risk and outcomes. By collecting stool samples from people newly diagnosed with colorectal cancer, researchers hope to find patterns that could improve understanding and future treatments.
Lisbon, Lisbon DistrictAges 40–74 - NCT06710756RecruitingPhase 1/Phase 2
Lead-212 therapy for solid tumors
This trial tests a new radioactive drug, Lead-212 PSV359, for people with advanced solid tumors that have not responded to standard treatments. The drug is designed to find and attack cancer cells.
Los Angeles, CaliforniaAges 18–90 - NCT06710314Enrolling by invitation
Metabolic syndrome and recovery after colorectal cancer surgery
This trial studies how metabolic syndrome (a mix of high blood pressure, diabetes, and other factors) changes after colorectal cancer surgery. It aims to understand why some people's metabolic syndrome gets better after their tumor is removed, which could lead to better treatments.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT06714357RecruitingPhase 2
Valproic Acid to Boost Anti-EGFR in Colorectal Cancer
This trial tests whether adding valproic acid to standard anti-EGFR plus irinotecan can stop or reverse resistance in metastatic colorectal cancer. It is for patients who previously responded well to an anti-EGFR drug and then progressed.
Caserta, CEAges 18 years+ - NCT06356714RecruitingPhase 2
Nocardia cell wall skeleton plus current therapy for colorectal cancer
This trial tests adding an investigational drug (Nocardia rubra cell wall skeleton) to the current treatment for people with advanced colorectal cancer that is stable but showing early signs of getting worse. It aims to see if this combination can help delay further progression.
Nanjing, JiangsuAges 18 years+ - NCT06696768RecruitingPhase 1
New drug plus standard chemotherapy for advanced colorectal cancer
This trial combines a new experimental drug (emavusertib) with standard chemotherapy (FOLFOX plus bevacizumab) for people with stage IV colorectal cancer who have not yet received chemotherapy. The goal is to see if the combination is safe and effective, potentially offering a new first-line treatment option.
Gainesville, FloridaAges 18 years+ - NCT06695845RecruitingPhase 2
Study of zanidatamab for HER2-positive solid tumors
This trial tests a drug called zanidatamab in people with advanced solid tumors that have high levels of HER2 protein (called HER2-positive). It aims to see if zanidatamab can shrink or slow the growth of these tumors.
Prescott, ArizonaAges 18 years+ - NCT06625775RecruitingPhase 1
Study of BBO-10203 for advanced solid tumors
This trial tests a new drug called BBO-10203, alone or combined with other cancer treatments, for people with certain advanced breast, colorectal, or lung cancers. It aims to see if the drug is safe and effective.
Duarte, CaliforniaAges 18 years+ - NCT06605430RecruitingPhase 2
Medical cannabis for advanced pancreatic and colorectal cancer
This trial tests whether medical cannabis can help reduce nausea, vomiting, appetite loss, wasting, and pain in people with advanced pancreatic or colorectal cancer who are starting chemotherapy. It's for Minnesota residents only.
Saint Louis Park, MinnesotaAges 18 years+ - NCT06589830RecruitingPhase 2
TL938 with Trastuzumab for HER2+ Colorectal Cancer
This trial is testing a new combination of drugs (TL938 and trastuzumab) for people with a specific type of advanced colorectal cancer that is HER2-positive and RAS wild-type. It may offer a new option if you have already tried standard chemotherapy and a blood vessel-blocking drug.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06588166Recruiting
Stool microbiome test for colon cancer screening
This study tests if a stool microbiome test can help find colorectal cancer early in people who already had a positive FIT screening test. You would give a stool sample and your microbiome results will be compared to what the colonoscopy finds.
RomaAges 50–74 - NCT06583564Enrolling by invitation
ICG dye during surgery for stage III colorectal cancer
This study tests whether using a special dye during surgery helps people with stage III colorectal cancer stay cancer-free longer. The dye, called indocyanine green (ICG), makes tumors and lymph nodes glow under a special camera, helping surgeons remove them more precisely.
Changning, Shanghai MunicipalityAges 18 years+ - NCT06580002RecruitingPhase 2
Can Riluzole Help with Chemo Brain? A Pilot Study
This study tests if a medicine called riluzole (currently used for ALS) can help with 'chemo brain' – memory and thinking problems after cancer treatment. It is for people who feel their mental sharpness has declined after breast cancer therapy, certain chemotherapies, or brain radiation.
Orange, CaliforniaAges 18 years+ - NCT06562543RecruitingPhase 4
Fruquintinib for advanced colorectal cancer in minority populations
This trial tests a medication called fruquintinib (an oral pill) for people with advanced colorectal cancer that has not responded to prior treatments. It is specifically looking for participants who identify as Black or African American and/or Hispanic or Latino to help understand how the drug works in these groups.
Birmingham, AlabamaAges 18 years+ - NCT06562192RecruitingPhase 1
Testing a radioactive drug for advanced pancreatic, lung, breast, and colorectal cancers
This trial tests a new radioactive drug (177Lu-NNS309) for people with advanced pancreatic, lung, breast, or colorectal cancer that has not responded to prior treatments. It aims to see if the drug can target and shrink tumors.
Birmingham, AlabamaAges 18–100 - NCT06557668Recruiting
Immunomodulator plus cancer therapy for colorectal cancer
This study looks at how well a type of drug called an immunomodulator, given together with other cancer treatments, works for people with colorectal cancer. It aims to see if combining these therapies can improve outcomes.
TaichungAges 20 years+
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Common questions
- Are there clinical trials for colorectal cancer?
- Yes. Clin2 currently lists 1,068 recruiting colorectal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.