Clinical trials
Colorectal Neoplasms clinical trials
Below are recruiting colorectal neoplasms clinical trials, each written for real people, not researchers. We’re tracking 135 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03823144Recruiting
Imaging small live tumor details during surgery
This study uses a special camera to look at solid tumors from inside the body during an operation. It tests whether “live” tumor imaging (using a medicine called fluorescein) can be safely performed in people with certain solid cancers.
Jacksonville, FloridaAges 18 years+ - NCT06051695RecruitingPhase 1/Phase 2
CAR T cell therapy for mesothelin-positive solid tumors
This trial tests a new type of immune cell therapy (CAR T-cells) designed to target cancer cells that have a protein called mesothelin but have lost a marker that lets them hide from the immune system. It's for people with advanced solid tumors who have already tried standard treatments.
Gilbert, ArizonaAges 18 years+ - NCT04008407Recruiting
Monitoring outcomes after removing certain colon growths
This study follows patients who are having surgery to remove a specific type of flat colon growth. It aims to see how safe and effective a “selective” approach is, based on what the growth looks like and your situation.
Westmead, New South WalesAges 18 years+ - NCT04130971Recruiting
Testing tumor tissue to understand and predict colorectal cancer response
This study looks at tissue samples from people with colorectal cancer to better understand tumor features and how they may respond to treatment. If you have colorectal cancer, the trial may help researchers match future treatments more effectively.
GothenburgAges 18 years+ - NCT06857773RecruitingPhase 3
Combined pump therapy and chemo for liver-only colorectal cancer
This trial tests a treatment approach where you receive chemotherapy directly into your liver through a surgically placed pump, combined with standard systemic chemotherapy (given through a vein). The goal is to shrink liver tumors enough so they can be removed later with surgery. It is for people whose colorectal cancer has spread only to the liver and has not been treated before.
AmsterdamAges 18 years+ - NCT06961149Recruiting
Comparing light vs dye spray for colon polyp detection
This study compares two methods used during colonoscopy to help find polyps in the colon. It tests whether a special light technique (linked-color imaging) or a dye spray (indigo carmine) works better for spotting adenomas, which are growths that can turn into cancer. If you are at higher risk for colorectal adenomas, this trial may help improve detection.
Jinan, ShandongAges 45–85 - NCT05396560Recruiting
Stool blood test to decide if follow-up colonoscopy is needed
This trial tests whether a stool blood test can help decide who truly needs a follow-up colonoscopy after prior colon polyps. It may reduce unnecessary colonoscopies while still catching concerning changes early.
Calgary, AlbertaAges 18–74 - NCT02222844Recruiting
MRI checks for treatment planning in sigmoid colon cancer
This study uses MRI scans to better plan “curative” treatment (aimed at cure) for sigmoid colon cancer before surgery. It is for people who may still be deciding on the radical (major, curative) treatment plan and who can safely have an MRI.
Huntingdon, CambridgeshireAges 16 years+ - NCT07629960RecruitingPhase 1/Phase 2
New KRAS-Targeting Drug for Advanced Solid Tumors
This early-stage trial tests BLU-924, a new drug designed to target cancer cells with specific KRAS mutations (a common genetic change in pancreatic, lung, and colon cancers). The study aims to find the right dose and see how well it works in patients whose cancers have progressed despite standard treatments.
Sarasota, FloridaAges 18 years+ - NCT06643793RecruitingPhase 2
Irinotecan liposome combo for advanced colorectal cancer
This trial tests a new form of the chemotherapy drug irinotecan (called irinotecan liposome) combined with two other chemo drugs and a targeted therapy (bevacizumab) for people with advanced colorectal cancer that has already been treated with oxaliplatin. The goal is to see if this combination can shrink tumors or slow the cancer's growth.
Nanjing, JiangsuAges 18–75 - NCT07346534Enrolling by invitation
Comparing reinforced vs. standard bowel connection in rectal cancer surgery
This study compares two ways of reconnecting the bowel after removing rectal cancer using keyhole surgery. It aims to see if a reinforced connection (with extra support) helps prevent leaks better than the standard method.
ShanghaiAges 18–85 - NCT07299071Recruiting
Computer-assisted detection to reduce advanced polyps at three-year follow-up
This trial tests whether a computer-aided detection (CAD) system helps doctors find more advanced polyps during screening colonoscopies, potentially reducing the risk of these polyps turning into cancer over three years. If you are undergoing a screening colonoscopy, this study may help improve early detection and prevention.
BayonneAges 18 years+ - NCT07239479Recruiting
Dexmedetomidine and desflurane for laparoscopic colon surgery
This study tests a combination of two drugs (dexmedetomidine and desflurane) used during keyhole colon surgery to see if it helps with recovery. It is designed for generally healthy adults having a planned laparoscopic colectomy.
Ho Chi Minh City, Ho Chi MinhAges 18–65 - NCT06403540Recruiting
Pain relief after belly surgery and diaphragm function
This study looks at how different pain relief methods after major abdominal surgery affect the diaphragm, a muscle that helps you breathe. It may help doctors choose the best way to manage pain while protecting your breathing.
IstanbulAges 18 years+ - NCT06208371RecruitingPhase 3
Local treatment vs. chemo for colorectal cancer with many liver spots
This trial tests whether treating all liver tumors with surgery, ablation, or radiation is better than continuing standard chemotherapy for people with colorectal cancer that has spread only to the liver. It's for those whose liver tumors have been controlled by initial chemotherapy and are considered removable.
Guangzhou, GuangdongAges 18 years+ - NCT06983639Recruiting
Fecal test vs. colonoscopy follow-up after polyp removal
This trial compares using a simple stool test (FIT) versus a repeat colonoscopy to check for new polyps in people who have already had an advanced adenoma removed. It aims to see if the stool test is a safe and effective alternative for routine follow-up.
Arendal, AgderAges 40–75 - NCT05913674RecruitingPhase 2
Feasibility of modified chemotherapy after bowel surgery
This Phase 2 study tests whether a modified chemotherapy given inside the abdomen soon after surgery is practical and safe. It may help people with appendix or colon cancer that has spread within the abdomen (peritoneal carcinomatosis) by targeting cancer cells after tumor removal.
Montreal, QuebecAges 18 years+ - NCT05643859Recruiting
Fiber supplement study for bowel health and gut bacteria
This study tests whether adding a dietary fiber supplement can change the bacteria in your colon (gut microbiome). You may be asked to take the fiber supplement during evaluation for a non-cancer rectal condition.
Portland, OregonAges 18 years+ - NCT05148494RecruitingPhase 4
Enema versus drink for bowel prep before rectal surgery
This trial compares two bowel-clearing methods—an enema given through the rectum versus an oral (by mouth) mechanical bowel prep—during a specific type of rectal surgery. It aims to find which method works better and is easier or safer for patients.
Halifax, Nova ScotiaAges 18–75 - NCT04222413RecruitingPhase 1
Study of metarrestin for advanced solid tumors
This study tests an experimental drug called metarrestin for people with solid tumors that have spread or come back after standard treatment. It may help by targeting a protein involved in cancer cell growth.
Fairway, KansasAges 12–120 - NCT05726136RecruitingPhase 4
Test fluid dosing during laparoscopic abdominal surgery
This trial tests a “fluid challenge” approach during surgery to better control your body’s fluid level. It may help guide how much fluid is safely given during longer laparoscopic abdominal operations.
Norrköping, Östergötland CountyAges 18–85 - NCT06265285RecruitingPhase 2
Nivolumab at home vs. clinic for cancer treatment
This study compares giving the immunotherapy drug nivolumab as a shot under the skin at home versus in the clinic. It is for people with certain cancers who are already taking or starting nivolumab.
Jacksonville, FloridaAges 18 years+ - NCT06978400RecruitingPhase 2
Targeted therapy plus chemo for BRAF mutant colorectal cancer
This trial tests a combination of targeted therapy (dabrafenib) and two other drugs (cetuximab or panitumumab) plus standard chemotherapy (FOLFOX) as a first treatment for people with a specific type of metastatic colorectal cancer that has a BRAF V600E mutation and is microsatellite stable.
MoscowAges 18 years+ - NCT04329494RecruitingPhase 1
Study of targeted drug delivery into the abdomen using PIPAC
This Phase 1 trial tests PIPAC, a way to deliver anti-cancer medicine directly into the abdomen using a minimally invasive procedure. It is for people with peritoneal spread from certain cancers to see whether this approach is safe and potentially helpful.
Duarte, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for colorectal neoplasms?
- Yes. Clin2 currently lists 135 recruiting colorectal neoplasms studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal neoplasms trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal neoplasms trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.