Clinical trials
Colorectal clinical trials
Below are recruiting colorectal clinical trials, each written for real people, not researchers. We’re tracking 1,202 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04861558RecruitingPhase 3
Warm chemotherapy placed in the abdomen to treat colon cancer
This Phase 3 trial tests whether heating chemotherapy and delivering it directly into the abdomen (along with standard surgery for cancer spread) works better for colon cancer that has spread to the lining of the abdomen. It may help control the cancer after surgery, especially when the spread is mainly in the abdomen (and possibly the liver or lungs).
AhmedabadAges 18–79 - NCT06208371RecruitingPhase 3
Local treatment vs. chemo for colorectal cancer with many liver spots
This trial tests whether treating all liver tumors with surgery, ablation, or radiation is better than continuing standard chemotherapy for people with colorectal cancer that has spread only to the liver. It's for those whose liver tumors have been controlled by initial chemotherapy and are considered removable.
Guangzhou, GuangdongAges 18 years+ - NCT07020117RecruitingPhase 1
Study of AKY-1189 for advanced solid tumors
This trial tests a new radioactive drug, AKY-1189, for people with solid tumors that have spread or cannot be removed. It may help if other treatments have stopped working.
Duarte, CaliforniaAges 18 years+ - NCT07014046Recruiting
Simple bed exercises after colorectal surgery
This study tests if doing simple leg and foot exercises while in bed after colorectal surgery can help your bowels start working again sooner and reduce bloating and discomfort.
Hong KongAges 18 years+ - NCT07007598Recruiting
Preventing bleeding after polyp removal with clips
This trial tests whether placing small clips at the site of polyp removal in the colon can reduce bleeding in patients who take blood thinners afterwards.
Schwerin, Mecklenburg-VorpommernAges 18 years+ - NCT07005453Recruiting
Studying a new way to measure polyp size during colonoscopy
This trial tests a tool that helps doctors more accurately measure the size of polyps found during colonoscopy. Accurate measurement helps decide the best next steps for your care.
Eindhoven, North BrabantAges 55–80 - NCT07012954RecruitingPhase 1/Phase 2
ctDNA-guided treatment for RAS/BRAF wild-type colorectal cancer
This trial tests a combination of two drugs—cetuximab or bevacizumab plus a chemotherapy pill (trifluridine/tipiracil)—for people with metastatic colorectal cancer that has no RAS or BRAF mutations. It's for patients whose cancer grew after first responding to cetuximab, and who have had other treatments since then.
Guangzhou, GuangdongAges 18–75 - NCT06998745Recruiting
Anticoagulant therapy support for colorectal cancer patients with blood clots
This trial tests whether a medication therapy management (MTM) model helps make blood thinner treatment safer and more effective for colorectal cancer patients who have also developed dangerous blood clots. It aims to improve how well patients stick to their medication and reduce complications.
Guangzhou, GuangdongAges 18–100 - NCT06309368RecruitingPhase 4
Wound irrigation method for ileostomy closure
This trial tests whether irrigating (cleaning) the wound with a special solution before closing the ostomy site helps it heal better, compared to the usual method. If you're having a loop ileostomy reversal, you may qualify.
Las Vegas, NevadaAges 18 years+ - NCT06995898Recruiting
Blood test study for early cancer detection
This study is testing a new blood test that may help find cancer early. You will give blood samples over a year, and researchers will check them for signs of cancer.
Pleasanton, CaliforniaAges 45–75 - NCT06997497RecruitingPhase 3
Study of Calderasib with other drugs for colorectal cancer
This trial tests a new drug called Calderasib combined with targeted therapy or chemotherapy for people with advanced colorectal cancer that has a specific genetic change (KRAS G12C mutation). It may be an option for those who have not had prior treatment for advanced disease.
Phoenix, ArizonaAges 18 years+ - NCT06943820RecruitingPhase 1/Phase 2
AK129 combination therapy for advanced solid tumors
This trial tests a new combination of drugs (including AK129) for people with advanced solid tumors, specifically lung cancer, head and neck cancer, or colorectal cancer. It is for those who have already tried a platinum chemo and a PD-1/PD-L1 drug but their cancer got worse.
Shenyang, LiaoningAges 18–75 - NCT06413212Recruiting
Personalized drug test for advanced cancer with fluid buildup
This trial uses a special test on your cancer cells to find which chemotherapy might work best for you. The aim is to treat advanced cancer that has caused fluid buildup in the chest or abdomen.
Wuhan, HubeiAges 18 years+ - NCT06997458Enrolling by invitation
Liquid biopsy study for advanced lung or colon cancer
This study is testing a simple blood draw (liquid biopsy) to track advanced lung or colon cancer. It may help doctors understand the cancer better without needing repeated tissue biopsies.
Granada, AndalusiaAges 18 years+ - NCT07003022RecruitingPhase 2
Two-drug combo for advanced colorectal cancer
This trial tests a combination of two drugs (cadonilimab and an anti-angiogenic agent) for advanced colorectal cancer that has a specific genetic feature (dMMR or MSI-H). It aims to find a new treatment option that might work better than current therapies.
Shanghai, ChinaAges 18–80 - NCT07001085Recruiting
Blood test to monitor liver cancer after surgery
This study uses a simple blood test to monitor tiny pieces of tumor DNA (ctDNA) in people with colorectal cancer that spread to the liver or with liver cancer (HCC), before and after liver surgery or transplant. It aims to help doctors detect cancer return earlier and guide treatment.
Warsaw, Masovian VoivodeshipAges 18–75 - NCT06996561RecruitingPhase 2/Phase 3
How your genes affect pain relief after surgery
This study looks at how your genes might affect pain relief from a medication called nalbuphine after abdominal or pelvic surgery. It aims to personalize pain management based on your genetic makeup.
Karachi, SindhAges 18–70 - NCT06983639Recruiting
Fecal test vs. colonoscopy follow-up after polyp removal
This trial compares using a simple stool test (FIT) versus a repeat colonoscopy to check for new polyps in people who have already had an advanced adenoma removed. It aims to see if the stool test is a safe and effective alternative for routine follow-up.
Arendal, AgderAges 40–75 - NCT06982885Recruiting
AI-assisted imaging study for colorectal lesions
This study tests whether artificial intelligence can help doctors see colorectal lesions more clearly using special advanced imaging. If you have a colorectal lesion, this trial may help improve diagnosis.
Changchun, JilinAges Any age - NCT05740956RecruitingPhase 1
Drug study for cancers with HRR gene or HRD changes
This Phase 1 study tests HS-10502 in people with advanced solid tumors that have certain DNA repair problems (HRR or HRD). It may help by finding a safe dose and seeing whether the drug can shrink tumors in cancers that have specific genetic features.
Beijing, Beijing MunicipalityAges 18–75 - NCT06974110RecruitingPhase 1
Study of a new drug for advanced solid tumors with MSI-H or dMMR
This trial tests an oral medication called MOMA-341 in people with advanced solid tumors that have high microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR). It aims to see if the drug can help when prior immunotherapy hasn't worked or isn't available.
Phoenix, ArizonaAges 18 years+ - NCT06964438Recruiting
Post-surgery electrical muscle stimulation study for colorectal or stomach cancer
This trial tests if using a mild electrical device on your legs after surgery can help you recover faster. It is for people with colorectal or stomach cancer who are having curative abdominal surgery.
Derby, DerbyshireAges 18 years+ - NCT06824623Recruiting
Preventing dehydration after ileostomy surgery
This trial tests a program to help patients with a new ileostomy avoid dehydration and hospital readmission by providing extra support and education.
Legnano, ItalyAges 18 years+ - NCT06957236Enrolling by invitation
NICE Procedure for Benign Colon Disease
This trial tests a new minimally invasive surgery called the NICE procedure for treating benign left-sided colon diseases like diverticulitis or benign polyps. It aims to see if this approach leads to fewer infections and better recovery compared to standard surgery.
Houston, TexasAges 18 years+
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Common questions
- Are there clinical trials for colorectal?
- Yes. Clin2 currently lists 1,202 recruiting colorectal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.