Clinical trials
Colorectal clinical trials
Below are recruiting colorectal clinical trials, each written for real people, not researchers. We’re tracking 1,199 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07084558Recruiting
Testing treatment guided by tumor DNA for hormone positive breast cancer
This trial tests whether using a blood test (circulating tumor DNA) can help guide chemo and hormone therapy for early-stage, hormone receptor positive and HER2 negative breast cancer. The goal is to tailor treatment to your tumor's response, potentially reducing unnecessary side effects.
Vienna, AustriaAges 18–100 - NCT07085091RecruitingPhase 1
Study of ALX2004 for advanced solid tumors
This trial tests a new drug, ALX2004, for people with certain advanced cancers (head and neck, lung, esophagus, or colorectal) that have stopped responding to standard treatments. The goal is to see if the drug is safe and effective.
La Jolla, CaliforniaAges 18 years+ - NCT06974500Recruiting
Bowel stimulation before ileostomy closure surgery
This study tests a stimulation program for the bowel loop before surgery to close an ileostomy. It may help your bowel get ready and improve recovery after the procedure.
MadridAges 18 years+ - NCT06978400RecruitingPhase 2
Targeted therapy plus chemo for BRAF mutant colorectal cancer
This trial tests a combination of targeted therapy (dabrafenib) and two other drugs (cetuximab or panitumumab) plus standard chemotherapy (FOLFOX) as a first treatment for people with a specific type of metastatic colorectal cancer that has a BRAF V600E mutation and is microsatellite stable.
MoscowAges 18 years+ - NCT05491434Recruiting
Study of muscle loss in colon cancer patients
This trial looks at muscle loss (called sarcopenia) in people with colon cancer to test an intervention that may help strength or recovery. If you’re age 70 or older and meet the cancer and health requirements, you may be able to take part.
L'Hospitalet de Llobregat, BarcelonaAges 70 years+ - NCT07069556Recruiting
ColoSense stool test study before colonoscopy
This study is testing a new stool-based screening test for colorectal cancer. You provide a stool sample before having a colonoscopy, and researchers compare the test results with what the colonoscopy finds.
St Louis, MissouriAges 18 years+ - NCT07066657RecruitingPhase 1
Study of MRG007 for advanced solid tumors
This trial tests a new drug called MRG007 for people with advanced solid tumors that haven't responded to other treatments. The drug targets a protein called CDH17 on cancer cells; you need a tumor sample to check for it.
Los Angeles, CaliforniaAges 18 years+ - NCT04742881Recruiting
Laparoscopic colon surgery comparison for bowel tumors or disease
This trial studies a low-impact approach to colon or upper-rectum surgery using small cameras (laparoscopy) to see if it works well and is safe. You may be eligible if you are scheduled for a specific type of colon/rectal operation and can safely be monitored during the study.
BayonneAges 18 years+ - NCT07058012RecruitingPhase 2
Testing immunotherapy for ctDNA-positive colorectal cancer after treatment
This trial is for people with colorectal cancer whose ctDNA blood test is still positive after surgery and chemotherapy. It tests two immunotherapy drugs (cemiplimab alone or with fianlimab) to see if they can eliminate the remaining cancer cells and prevent the cancer from coming back.
Gainesville, FloridaAges 18 years+ - NCT07056374Recruiting
New bowel connection method for colon or rectal cancer surgery
This trial tests a new way of connecting the bowel after removing cancer or precancerous lesions in the sigmoid colon or upper rectum. It is for patients who are having planned, curative surgery and may help reduce complications.
AmsterdamAges 18 years+ - NCT06982872Recruiting
AI-assisted scope test for colorectal growths
This trial tests how well different artificial intelligence tools can help doctors see and diagnose growths in the colon during a special type of scope exam. It may help find better ways to detect polyps and other lesions.
Changchun, JilinAges Any age - NCT07046585Recruiting
Blood test for colon cancer screening
This trial tests a new blood test to screen for colorectal cancer in people at average risk. You would give a blood sample before your scheduled colonoscopy, and the results will be compared to the colonoscopy findings.
Austin, TexasAges 40 years+ - NCT07046468Recruiting
Smart pill to check gut health in colon inflammation and cancer
This trial tests a smart pill that measures gut health in people with colon inflammation (ulcerative colitis) or colon cancer. It aims to see if the pill can help doctors better understand how the gut is working during treatment or before surgery.
Nijmegen, GelderlandAges 18 years+ - NCT06991465RecruitingPhase 2
Organ preservation trial for rectal cancer using shorter radiation
This trial tests a shorter course of radiation to the pelvis to treat rectal cancer, with the goal of avoiding surgery and preserving the rectum. It may be an option for people with advanced rectal cancer that has not spread to other organs.
Montreal, QuebecAges 18–90 - NCT07043387Recruiting
Simplified radioembolization for liver cancer and bile duct cancer
This trial tests a streamlined way to deliver radioactive beads (radioembolization) directly to liver tumors in people with metastatic liver cancer or bile duct cancer. It aims to make treatment simpler and safer while still effectively targeting tumors.
Goyang-siAges 19 years+ - NCT07035587Recruiting
A blood test to detect multiple cancers and monitor leftover tumors after treatment
This trial uses a blood test to find early signs of cancer or leftover tumor cells after treatment. It may help people with certain cancers or those with non-cancerous growths understand their condition better.
SeoulAges 19 years+ - NCT07042243Recruiting
Florida ASCENT cancer study for patients and providers
This study looks at cancer care in Florida. If you have had cancer in the past and are not currently getting active treatment (like chemotherapy or radiation), this study may help researchers understand how to improve care.
Gainesville, FloridaAges 18–100 - NCT07030257RecruitingPhase 1/Phase 2
Study of CP-383 for advanced solid tumors
This study tests a new drug called CP-383 for people with advanced solid tumors that have not responded to other treatments. The goal is to see if it can shrink tumors or slow cancer growth, especially for certain cancers with genetic changes.
Denver, ColoradoAges 18 years+ - NCT05727163RecruitingPhase 2
Liver-directed chemotherapy versus standard chemotherapy for RAS-mutated CRC
This Phase 2 study tests whether delivering chemotherapy directly into the liver (with an IV medicine added, depending on the group) works better than standard chemotherapy given through a vein. It is for people whose colorectal cancer has spread to the liver but can’t be removed by surgery yet.
Guangzhou, GuangdongAges 18–75 - NCT07026786Recruiting
Mindfulness for recovery after colorectal surgery
This study tests whether adding mindfulness sessions to your standard recovery plan helps you heal better after bowel surgery. You'll use a phone or tablet app to guide your mindfulness practice during your hospital stay.
Cleveland, OhioAges 18 years+ - NCT04861558RecruitingPhase 3
Warm chemotherapy placed in the abdomen to treat colon cancer
This Phase 3 trial tests whether heating chemotherapy and delivering it directly into the abdomen (along with standard surgery for cancer spread) works better for colon cancer that has spread to the lining of the abdomen. It may help control the cancer after surgery, especially when the spread is mainly in the abdomen (and possibly the liver or lungs).
AhmedabadAges 18–79 - NCT06208371RecruitingPhase 3
Local treatment vs. chemo for colorectal cancer with many liver spots
This trial tests whether treating all liver tumors with surgery, ablation, or radiation is better than continuing standard chemotherapy for people with colorectal cancer that has spread only to the liver. It's for those whose liver tumors have been controlled by initial chemotherapy and are considered removable.
Guangzhou, GuangdongAges 18 years+ - NCT07020117RecruitingPhase 1
Study of AKY-1189 for advanced solid tumors
This trial tests a new radioactive drug, AKY-1189, for people with solid tumors that have spread or cannot be removed. It may help if other treatments have stopped working.
Duarte, CaliforniaAges 18 years+ - NCT07014046Recruiting
Simple bed exercises after colorectal surgery
This study tests if doing simple leg and foot exercises while in bed after colorectal surgery can help your bowels start working again sooner and reduce bloating and discomfort.
Hong KongAges 18 years+
Hear when a new Colorectal trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for colorectal?
- Yes. Clin2 currently lists 1,199 recruiting colorectal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.