Clinical trials
Colorectal clinical trials
Below are recruiting colorectal clinical trials, each written for real people, not researchers. We’re tracking 1,202 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05517811Recruiting
Blood clotting tests before and after surgery for cancer
This study looks at how cancer and surgery affect blood clotting. It may help doctors understand and prevent blood clots in patients having surgery for certain cancers.
Aurora, ColoradoAges 18–99 - NCT05492682RecruitingPhase 1
First-in-human treatment for cancer using a drug injected into tumors
This Phase 1 trial tests PeptiCRAd-1, a treatment injected into a tumor, to see how safe it is and whether it can shrink cancers. It studies people whose cancer has come back or can’t be treated with standard options.
FrankfurtAges 18 years+ - NCT05489211RecruitingPhase 2
Testing a cancer drug for advanced solid tumors
This Phase 2 study tests the drug Dato-DXd (alone or with other cancer medicines) in people with advanced solid tumors. It looks for tumor shrinkage and how safely the treatment can be given.
Los Angeles, CaliforniaAges 18–130 - NCT05482893RecruitingPhase 1/Phase 2
Study of spevatamig for advanced gastrointestinal cancers
This trial tests a new drug called spevatamig (PT886) alone or with other treatments for advanced stomach, gastric, pancreatic, bile duct, or colorectal cancers. The goal is to see if it helps slow or stop cancer growth.
Duarte, CaliforniaAges 18 years+ - NCT04722341Recruiting
Time-limited eating for people with certain breast or rectal cancers
This study tests whether eating only within a shorter daily time window can improve cancer outcomes in people with specific breast or rectal cancers. It also looks at how this affects the body (such as metabolism) and who is most likely to benefit.
Birmingham, AlabamaAges 18 years+ - NCT05391126Recruiting
Genetic test helps choose drug dosing for pancreas or colon cancer
This study tests whether using a genetic test to guide medication doses works better than standard dosing for people with certain pancreas or colon cancers. It may help by tailoring treatment more precisely to your tumor’s genetic features.
Lexington, KentuckyAges 18 years+ - NCT05427487RecruitingPhase 1
Testing a medicine injected into tumors for advanced cancers
This Phase 1 study tests IVX037, a medicine given directly into a solid tumor, to see if it is safe and may shrink tumors. It is for people with certain advanced colorectal, stomach/gastroesophageal, or ovarian cancers that have limited treatment options.
Sydney, New South WalesAges 18–85 - NCT05443087Recruiting
Checking blood levels of targeted drugs for digestive cancers
This trial monitors how your prescribed targeted cancer medicine moves through your body by doing extra blood tests. The goal is to understand the drug’s levels and dosing in people with advanced digestive cancers, so treatment can be better managed.
AmiensAges 18 years+ - NCT05366881Recruiting
Blood test study to spot early cancer signal and cancer leftovers
This observational study checks whether a blood test (a “cfDNA” test) can detect early signs of cancer or small amounts of cancer left after treatment. It may help doctors use a simple blood sample to improve cancer detection and follow-up.
Duarte, CaliforniaAges 40 years+ - NCT05379985RecruitingPhase 1/Phase 2
Test drug RMC-6236 for certain RAS mutations in advanced cancers
This trial tests whether RMC-6236 can treat advanced solid tumors that have specific RAS-related gene changes (especially certain KRAS G12 mutations). You may be able to join if your tumor’s DNA test shows the right mutation and your overall health is good enough for study visits.
Orange, CaliforniaAges 18 years+ - NCT05411718RecruitingPhase 2
Aspirin or naproxen to prevent cancer in Lynch syndrome
This trial tests whether daily aspirin or naproxen can “intercept” (stop) cancer from starting or coming back in people with Lynch syndrome who are currently cancer-free. Participants are randomly assigned to one of the two drugs, and neither the participant nor the team knows which one you’re taking.
Houston, TexasAges 18 years+ - NCT05403177Recruiting
Share your cancer data and samples for Ontario research
This study collects and combines medical records, genetic (genomic) data, and tumor/blood samples from people with cancer. It helps researchers build and improve a large “gold standard” cancer dataset that can support future studies and better understanding of cancer.
Kingston, OntarioAges 18 years+ - NCT05402696Recruiting
Study of advanced surgery care for colorectal tumors
This study follows adults who are referred for treatment of a specific type of colorectal tumor that involves the left side of the colon. It aims to improve care and outcomes for people needing advanced surgery.
Saint Cloud, MinnesotaAges 18 years+ - NCT05404230Recruiting
Preventing nerve damage from oxaliplatin in the hands and feet
This study looks at ways to prevent numbness or nerve pain in the hands and feet that can happen from oxaliplatin treatment. It includes people with colon or rectal cancer who will be getting standard chemotherapy with capecitabine plus oxaliplatin.
AalborgAges 18 years+ - NCT05319314RecruitingPhase 1/Phase 2
Study drug for advanced colon cancer that has come back or failed
This Phase 1/2 trial tests LYL273, a new targeted treatment, for people with metastatic colorectal (colon) cancer that has returned or not responded to standard chemo. It’s designed to see how well the drug can control the cancer and what side effects it causes.
Duarte, CaliforniaAges 18 years+ - NCT05334485RecruitingPhase 2/Phase 3
Pyridostigmine to treat slow bowel recovery after colorectal surgery
This trial tests whether pyridostigmine helps return bowel function faster after colorectal surgery when the gut is “stuck,” causing bloating and no gas or stool. It also checks safety and side effects compared with standard care.
Cleveland, OhioAges 18 years+ - NCT05288205RecruitingPhase 1/Phase 2
JAB-21822 plus JAB-3312 for KRAS G12C solid tumors
This Phase 1/2a trial tests two investigational pills (JAB-21822 and JAB-3312) in people with advanced solid cancers that have a KRAS G12C mutation. It’s for cases where standard treatments have failed or aren’t suitable, to see if the drugs can shrink tumors and improve outcomes.
Hefei, AnhuiAges 18 years+ - NCT05244278Recruiting
AI tool that helps find and classify colon polyps during colonoscopy
This trial tests an artificial-intelligence (AI) software tool that helps doctors spot and categorize polyps in real time during a colonoscopy. It may help improve how accurately and quickly polyps are detected during routine and medical colon exams.
Montreal, QuebecAges 45–89 - NCT05239546RecruitingPhase 2
Dostarlimab before colon surgery for mismatch-repair–deficient cancer
This study tests dostarlimab given before surgery for stage II or III colon cancer that has a specific DNA repair defect. It aims to shrink or control the cancer so that some people may be able to skip surgery if the results are good.
Iowa City, IowaAges 18 years+ - NCT05225428Recruiting
Video education program based on personal genetic result disclosure
This study tests a video-based education approach that shares information differently depending on someone’s genetic test results. It may help people better understand cancer-related genetic information and what it could mean for them.
Boston, MassachusettsAges 18 years+ - NCT05176483RecruitingPhase 1
New drug combinations for advanced solid tumors
This trial tests a new drug called zanzalintinib, which may slow or shrink various types of advanced cancer. It is given together with other cancer treatments, and the study is looking at many different cancers including kidney, prostate, bladder, lung, liver, and more.
Phoenix, ArizonaAges 18 years+ - NCT05195710RecruitingPhase 1
Pre-surgery Y-90 treatment to grow future liver volume
This trial tests a radiation treatment called Y-90 given before liver surgery for colorectal cancer that has spread to the liver. The goal is to help the liver grow enough for safer, curative surgery, either right away or as part of a two-step operation.
Houston, TexasAges 18 years+ - NCT05148494RecruitingPhase 4
Enema versus drink for bowel prep before rectal surgery
This trial compares two bowel-clearing methods—an enema given through the rectum versus an oral (by mouth) mechanical bowel prep—during a specific type of rectal surgery. It aims to find which method works better and is easier or safer for patients.
Halifax, Nova ScotiaAges 18–75 - NCT05086692RecruitingPhase 1/Phase 2
Beta-only IL-2 therapy for advanced solid tumors
This Phase 1/2 study tests a beta-only version of IL-2, an immune-stimulating treatment, to shrink or control advanced or metastatic solid tumors. It’s mainly designed to check safety and to see if it can help patients by improving tumor response.
San Diego, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for colorectal?
- Yes. Clin2 currently lists 1,202 recruiting colorectal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.