Clinical trials
Coronary Artery Disease (Left Main) clinical trials
Below are recruiting coronary artery disease (left main) clinical trials, each written for real people, not researchers. We’re tracking 124 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06855537RecruitingPhase 4
Treating unstable plaques that are not fully blocked
This trial compares treatments for heart patients who have a dangerous, but not fully blocking, fatty plaque in their arteries. It aims to see if treating these plaques with a stent or balloon can prevent future heart problems.
Beijing, Beijing MunicipalityAges 18–80 - NCT04973579Recruiting
Stent plus heart surgery for high risk carotid patients
This trial looks at whether doing carotid artery stenting at the same time as heart surgery is safe and effective for people at high risk of stroke around the time of surgery. It targets people with significant carotid narrowing who also need heart surgery for specific heart problems.
KrakowAges 18 years+ - NCT05230446Recruiting
Testing full stent treatment for heart artery blockages
This study looks at how well doctors can treat multiple blocked heart arteries using a specific drug-eluting stent, aiming to fully open them. It may help patients whose blockage pattern fits the study, but it does not include certain high-risk or special cases.
Rotterdam, South HollandAges 18–85 - NCT05532631Recruiting
Compare stent procedure versus bypass surgery for weak heart
This study compares two ways to improve blood flow to the heart—using stents through a catheter or bypass surgery—in people with heart muscle weakness and blockages in more than one coronary artery. It may help identify which approach leads to better outcomes over at least two years.
Créteil, Val De MarneAges 18 years+ - NCT05775445Recruiting
People with very blocked or very normal coronary arteries
This study compares people with very severe coronary artery disease to those without significant disease, using heart imaging data. It aims to understand what differs between extreme cases and how that information could guide future care.
SingaporeAges 21–99 - NCT05931783Recruiting
Compare two ways to use an artery during heart bypass
This study compares two surgical techniques for heart bypass: using the left internal thoracic artery in one specific way versus another. It may help improve how well the bypass works in people who need bypass surgery for multiple blocked heart arteries.
GrazAges 18–80 - NCT07811024Recruiting
Strolimus-coated balloon for blocked coronary arteries
This study tests a balloon coated with a drug that may help keep arteries open after they've been cleared, especially for people with a narrowing inside a previously placed stent or in a small heart artery. It's a first-time-in-humans study to check if the treatment is safe and works.
TashkentAges 21 years+ - NCT07814157Recruiting
Basel registry study on complex heart artery procedures
This study collects information on patients who have complex heart artery procedures at the University Hospital in Basel, to track how well these treatments work and how safe they are.
Basel, Canton of Basel-CityAges 18 years+ - NCT07795398RecruitingPhase 4
Stopping aspirin in older adults with stable heart disease
This trial tests whether older adults with stable heart disease can safely stop taking daily aspirin after two years without increasing the risk of heart attack or stroke. It may help reduce the side effects of long-term aspirin use.
CopenhagenAges 65 years+ - NCT07742345Recruiting
Coronary support catheter for safer stent placement
This study tests a catheter that helps doctors guide stents and balloons through blocked heart arteries. It may make your procedure easier and safer if you need a stent placed.
BeijingAges 18 years+ - NCT07724184Recruiting
Treating calcified heart arteries with a stent
This trial tests a way to treat hardened, calcified heart artery blockages using a stent. It may help people who have moderate blockages that haven't been treated before.
AalborgAges 18–90 - NCT07708805Recruiting
Heart blood flow imaging study
This study tests a special heart scan that measures blood flow to the heart muscle. It may help doctors decide if your heart blockages need treatment or if medication is enough.
Orléans, LoiretAges 18 years+ - NCT07711106Recruiting
Comparing expert IVUS to standard IVUS for left main artery stenting
This study compares two ways of using a special ultrasound camera (IVUS) inside your heart's main artery during stenting. The goal is to see if a new 'expert' computer system helps the doctor place the stent better than the standard IVUS method. It may help people with blockages at the Y-shaped split of the left main artery.
Saint PetersburgAges 18 years+ - NCT07691502Recruiting
Using CT scans before angioplasty to plan treatment
This trial tests if using a special heart CT scan (CCTA with FFRCT) before a planned angioplasty can help doctors better plan where to place stents. You may be eligible if you have a narrowing in one or two heart arteries that haven't been treated before.
Minneapolis, MinnesotaAges 22 years+ - NCT06075602Recruiting
Complex and calcified coronary artery disease: a registry study
This study watches how people with complex or calcified heart artery disease are treated (with stents or bypass surgery) and how they do over time. It aims to learn which treatments work best for tough blockages.
Lucerne, Canton of LucerneAges 18 years+ - NCT07628270Recruiting
Heart Surgery Outcomes Study Using CT Scans and Blood Tests
This study follows patients who had heart bypass surgery guided by special CT scans and blood flow measurements. Researchers want to understand how well the surgery works and study a blood protein called Lp(a) that may affect heart health.
Milan, MIAges 18 years+ - NCT07613996Recruiting
Blood Flow Measurement During Heart Imaging
This study examines how a special measurement technique works when blood vessels are dilated during a heart imaging procedure. It may help doctors better assess whether narrowing in your heart arteries needs treatment.
Shanghai, Please SelectAges 18 years+ - NCT07596706Recruiting
Comparing two stent techniques for left main branch blockages
This trial compares two ways of placing a stent at the point where the main left artery splits into two branches. It is for people who have a blockage in the very beginning of one of those branches, and it uses advanced drug-eluting stents to see which method works better.
Istanbul, Please SelectAges 18–85 - NCT07521007RecruitingPhase 2
YN001 treatment for coronary artery disease
This study tests whether a new drug called YN001 can help people with coronary atherosclerosis (narrowing of heart blood vessels). The trial aims to see if it can improve outcomes in people who have early-stage blockages in their heart arteries.
Huntsville, AlabamaAges 18–80 - NCT07524335RecruitingPhase 3
Aspirin for early coronary artery disease without symptoms
This trial tests whether taking aspirin can help people who have early signs of coronary artery disease (buildup in heart arteries) but have never had a heart attack or stroke. The goal is to see if aspirin prevents future heart problems in these patients.
Montreal, QuebecAges 40 years+ - NCT05544864Recruiting
Stent or balloon treatment guided by heart scar pattern
This study looks at how to treat blocked heart arteries that have narrowed again after a prior drug-eluting stent. It compares using another drug-eluting stent versus a drug-coated balloon, chosen based on an imaging scan inside the artery (OCT), to reduce repeat narrowing.
Frankfurt am Main, HesseAges 18 years+ - NCT07463664Recruiting
Drug-coated balloons for blocked heart arteries
This trial tests whether a drug-coated balloon, used without a permanent stent, can safely open completely blocked heart arteries that have been blocked for at least 3 months. It may offer an option that avoids leaving a metal stent behind.
Beijing, Beijing MunicipalityAges 18–80 - NCT07444957Recruiting
Safety of a drug-coated balloon for heart artery blockages
This study tests a special balloon coated with a drug called sirolimus to open blocked heart arteries. It may be an option for people with coronary artery disease who need a less invasive treatment.
Vigo, PontevedraAges 18 years+ - NCT06002932Recruiting
Comparing one-stent with drug balloon vs. two-stents for heart artery branches
This study compares two ways to treat a narrowed heart artery where a smaller branch vessel is also blocked. One approach uses a drug-coated balloon on the side branch, while the other places a second stent. The goal is to see which method works better for patients like you.
Suwon, Gyeonggi-doAges 19 years+
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Common questions
- Are there clinical trials for coronary artery disease (left main)?
- Yes. Clin2 currently lists 124 recruiting coronary artery disease (left main) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a coronary artery disease (left main) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a coronary artery disease (left main) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.