Clinical trials
Coronary Artery Disease (Left Main) clinical trials
Below are recruiting coronary artery disease (left main) clinical trials, each written for real people, not researchers. We’re tracking 123 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06374498Enrolling by invitation
Looking inside heart arteries to improve stent placement
This study tests a new imaging technique to help doctors see inside your heart arteries during a stent procedure. It may help guide treatment and improve outcomes for people with heart disease.
Boston, MassachusettsAges 18 years+ - NCT07422688Enrolling by invitation
Using light scans to find heart artery blockages
This trial uses a special light-based scan (optical coherence tomography, or OCT) to help doctors see inside your heart arteries and find the exact blockage causing your heart attack. It may help guide treatment more precisely.
GenkAges 18 years+ - NCT07286578Recruiting
Using heart CT scans to guide treatment for blocked arteries
This trial is testing whether a special heart CT scan (coronary CT angiography) can help doctors better understand and treat calcium buildup in your heart arteries. If you have a type of heart disease that might need a stent or other procedure, this study could help decide the best approach.
Boston, MassachusettsAges 18–85 - NCT07159087Enrolling by invitation
New drug balloon for re-narrowed stents
This trial tests a new drug-coated balloon (Genoss SCB) versus an existing one (SeQuent Please NEO) for people whose heart stents have re-narrowed. It aims to see which balloon better keeps the artery open.
Gyeonggi-doAges 19 years+ - NCT07407738Recruiting
A trial of a shockwave device for calcified heart arteries
This trial tests a new device that uses sound waves to break up calcium deposits in heart arteries before placing a stent. It is for people with severely hardened arteries that are hard to treat with standard methods.
LyonAges 18 years+ - NCT07195149RecruitingPhase 3
Aspirin dose comparison after bypass surgery
This trial tests whether a lower dose of aspirin combined with another blood thinner (prasugrel) after bypass surgery is as safe and effective as a higher dose. It is for people with stable heart disease who are scheduled for bypass surgery and have not had a recent heart attack.
BialystokAges 18 years+ - NCT07232069RecruitingPhase 3
Early heart disease trial for women and men with mild plaque buildup
This trial tests whether two medicines, a statin and colchicine, can slow or stop early heart artery plaque from growing in people who have mild plaque but no heart disease symptoms yet. It uses special CT scans to measure plaque over 2 years.
Birmingham, AlabamaAges 30–60 - NCT06959524Recruiting
AGENT balloon for new heart artery blockages
This trial tests a drug-coated balloon (AGENT DCB) versus standard angioplasty/stenting for new blockages in heart arteries. It aims to see if the coated balloon works better and is safe for people who haven't had prior stents in that spot.
La Jolla, CaliforniaAges 18 years+ - NCT06822712Recruiting
Sirolimus-coated balloon for heart artery branch blockages
This trial tests a new balloon coated with sirolimus (a drug that helps prevent re-blockage) for treating blocked arteries at branch points (bifurcations) in the heart. If you have a blocked artery at a branch point, this study may offer a way to treat the side branch without placing a stent there.
Lanzhou, GansuAges 18–80 - NCT07341932Recruiting
Heart mapping test for stable coronary artery disease treatment
This trial tests whether a non-invasive heart mapping technique can guide treatment for stable coronary artery disease, potentially avoiding more expensive or invasive tests. You may join if you have stable angina and a blockage of 50-90% in a major heart artery.
Beijing, Beijing MunicipalityAges 18–80 - NCT07004569Recruiting
Angiolite Registry Study for heart artery stents
This study is testing a new type of stent for people with a blockage in the main artery of the heart. It aims to see how well the stent works and if it's safe.
Hong Kong, ShatinAges 19 years+ - NCT06985693Recruiting
AI-assisted stent placement study for heart disease
This trial tests whether a new artificial intelligence tool called Medipixel XA can help doctors place stents more precisely in blocked heart arteries. If you have coronary artery disease and need a stent, this study could be an option.
Gwangmyeong, Gyeonggi-doAges 19 years+ - NCT06939374Recruiting
Freezing heart arteries to stabilize high-risk plaques
This study tests a special cooling balloon to freeze and stabilize dangerous plaques in heart arteries that are not the main cause of your current symptoms. It aims to prevent future heart attacks.
AalstAges 18 years+ - NCT06919562Recruiting
Better stent placement using imaging and newer scaffolds
This trial tests if using advanced imaging (like OCT or IVUS) to guide placement of a newer type of stent (bioresorbable scaffold) can reduce future stent problems. It is for people with stable coronary artery disease who need a stent in a main heart artery.
DordrechtAges 18 years+ - NCT07628270Recruiting
Heart Surgery Outcomes Study Using CT Scans and Blood Tests
This study follows patients who had heart bypass surgery guided by special CT scans and blood flow measurements. Researchers want to understand how well the surgery works and study a blood protein called Lp(a) that may affect heart health.
Milan, MIAges 18 years+ - NCT07133984Recruiting
Heart imaging study for people with heart failure and blocked arteries
This study uses heart MRIs to learn more about people who have heart failure and significant blockages in their coronary arteries. If you are planning to have bypass surgery or a stent, the study may be a fit.
Brooklyn, New YorkAges 18 years+ - NCT06657833Recruiting
Drug Balloon vs Stent for Calcified Nodules After Shockwave
This trial tests whether a drug-coated balloon (a tiny balloon that releases medicine) works as well as a drug-coated stent (a mesh tube) for treating hard calcium deposits in heart arteries. Patients first receive a special shockwave treatment to break up the calcium.
LeidenAges 18 years+ - NCT07521007RecruitingPhase 2
YN001 treatment for coronary artery disease
This study tests whether a new drug called YN001 can help people with coronary atherosclerosis (narrowing of heart blood vessels). The trial aims to see if it can improve outcomes in people who have early-stage blockages in their heart arteries.
Huntsville, AlabamaAges 18–80 - NCT07742345Recruiting
Coronary support catheter for safer stent placement
This study tests a catheter that helps doctors guide stents and balloons through blocked heart arteries. It may make your procedure easier and safer if you need a stent placed.
BeijingAges 18 years+ - NCT06779630Recruiting
Study of a 48mm drug-coated stent for long coronary artery blockages
This trial tests a longer-than-usual drug-coated stent (Orsiro Mission) for treating long blockages in heart arteries. It aims to see if the stent is safe and effective for people with coronary artery disease.
Concord, CaliforniaAges 18 years+ - NCT07258290Recruiting
Freesolve Magnesium Scaffold for Heart Artery Blockages
This trial tests a new dissolvable magnesium scaffold to treat blockages in heart arteries. It is designed for people with stable heart pain or certain recent heart attacks, and it aims to open blocked arteries and then slowly dissolve over time.
Washington D.C., District of ColumbiaAges 18–80 - NCT07724184Recruiting
Treating calcified heart arteries with a stent
This trial tests a way to treat hardened, calcified heart artery blockages using a stent. It may help people who have moderate blockages that haven't been treated before.
AalborgAges 18–90 - NCT07045194Recruiting
Study of Virtue balloon for coronary stent re-narrowing
This trial tests a special balloon to treat narrowed areas inside a previously placed heart stent. It may help by reopening the artery without adding another stent.
Gainesville, FloridaAges 18 years+ - NCT07711106Recruiting
Comparing expert IVUS to standard IVUS for left main artery stenting
This study compares two ways of using a special ultrasound camera (IVUS) inside your heart's main artery during stenting. The goal is to see if a new 'expert' computer system helps the doctor place the stent better than the standard IVUS method. It may help people with blockages at the Y-shaped split of the left main artery.
Saint PetersburgAges 18 years+
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Common questions
- Are there clinical trials for coronary artery disease (left main)?
- Yes. Clin2 currently lists 123 recruiting coronary artery disease (left main) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a coronary artery disease (left main) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a coronary artery disease (left main) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.