Clinical trials
Coronary Artery Disease (Left Main) clinical trials
Below are recruiting coronary artery disease (left main) clinical trials, each written for real people, not researchers. We’re tracking 123 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06374498Enrolling by invitation
OCT-NIRAF imaging for heart artery procedures
This trial is testing a new imaging tool (OCT-NIRAF) that helps doctors see inside your heart arteries during a catheterization procedure. It is for patients getting a stent or balloon treatment, and it may help guide the procedure to make it safer and more effective.
Boston, MassachusettsAges 18 years+ - NCT07422688Enrolling by invitation
Using light scans to find heart artery blockages
This trial uses a special light-based scan (optical coherence tomography, or OCT) to help doctors see inside your heart arteries and find the exact blockage causing your heart attack. It may help guide treatment more precisely.
LeuvenAges 18 years+ - NCT04973579Recruiting
Stent plus heart surgery for high risk carotid patients
This trial looks at whether doing carotid artery stenting at the same time as heart surgery is safe and effective for people at high risk of stroke around the time of surgery. It targets people with significant carotid narrowing who also need heart surgery for specific heart problems.
KrakowAges 18 years+ - NCT05230446Recruiting
Testing full stent treatment for heart artery blockages
This study looks at how well doctors can treat multiple blocked heart arteries using a specific drug-eluting stent, aiming to fully open them. It may help patients whose blockage pattern fits the study, but it does not include certain high-risk or special cases.
Rotterdam, South HollandAges 18–85 - NCT05347069RecruitingPhase 4
Aspirin study for people with stable heart artery disease
This trial tests whether daily aspirin is safe and effective for people who have stable (chronic) coronary artery disease but cannot have procedures to open blocked arteries. It may help reduce future heart problems, while also checking for side effects and risks from aspirin.
KyotoAges 20 years+ - NCT05532631Recruiting
Compare stent procedure versus bypass surgery for weak heart
This study compares two ways to improve blood flow to the heart—using stents through a catheter or bypass surgery—in people with heart muscle weakness and blockages in more than one coronary artery. It may help identify which approach leads to better outcomes over at least two years.
Créteil, Val De MarneAges 18 years+ - NCT05544864Recruiting
Stent or balloon treatment guided by heart scar pattern
This study looks at how to treat blocked heart arteries that have narrowed again after a prior drug-eluting stent. It compares using another drug-eluting stent versus a drug-coated balloon, chosen based on an imaging scan inside the artery (OCT), to reduce repeat narrowing.
Frankfurt am Main, HesseAges 18 years+ - NCT05650411Recruiting
Test new drug-eluting stent with less blood thinner
This study compares a new type of “drug-eluting” stent (a tiny scaffold that slowly releases medicine) and a single blood-thinner plan versus the usual two-drug blood thinner plan after stent placement in the left main coronary artery. It aims to see if the simpler plan can work while keeping the stent safe.
Zurich, Canton of ZurichAges 18 years+ - NCT05775445Recruiting
People with very blocked or very normal coronary arteries
This study compares people with very severe coronary artery disease to those without significant disease, using heart imaging data. It aims to understand what differs between extreme cases and how that information could guide future care.
SingaporeAges 21–99 - NCT05799092Recruiting
Invasive vs non-invasive test for less-severe blocked heart arteries
This study compares two approaches to evaluating and treating people with symptoms of blocked heart arteries that are not “high-risk.” It may help doctors choose the safest, most effective next step for you by comparing invasive testing versus non-invasive evaluation.
Bucheon-siAges 19 years+ - NCT05807841Recruiting
AI ultrasound during stent placement in heart artery blockages
This trial tests an artificial-intelligence tool that uses a heart ultrasound to help guide stent treatment. It may help doctors choose the best way to treat blockages and improve stent results for people with symptoms from reduced blood flow to the heart.
Bucheon-siAges 19 years+ - NCT05829889Recruiting
FFR test versus angiogram to guide left main heart treatment
This trial compares two ways to decide how to treat a narrowed “left main” coronary artery: a pressure-based test (FFR) versus standard X-ray imaging (angiography). It aims to see which approach better helps choose safe, appropriate treatment using a stent when appropriate.
Hong KongAges 20 years+ - NCT05831085Recruiting
Compare procedures to improve heart blood flow in diabetes
This study compares two ways to restore blood flow to the heart—stent placement (PCI) versus bypass surgery (CABG)—in people with diabetes and significant multi-vessel coronary artery disease. It looks at outcomes using both standard heart tests and additional imaging/functional measurements to guide the best revascularization strategy.
Palo Alto, CaliforniaAges 20 years+ - NCT05908331Recruiting
Balloon treatment test for narrowed stents in heart arteries
This trial tests whether a special drug-coated balloon (“MagicTouch”) can treat re-narrowing inside a previously placed stent. It may help patients whose stent has become blocked again, by improving blood flow and reducing repeat narrowing.
Birmingham, AlabamaAges 18–110 - NCT05931783Recruiting
Compare two ways to use an artery during heart bypass
This study compares two surgical techniques for heart bypass: using the left internal thoracic artery in one specific way versus another. It may help improve how well the bypass works in people who need bypass surgery for multiple blocked heart arteries.
GrazAges 18–80 - NCT06002932Recruiting
Comparing one-stent with drug balloon vs. two-stents for heart artery branches
This study compares two ways to treat a narrowed heart artery where a smaller branch vessel is also blocked. One approach uses a drug-coated balloon on the side branch, while the other places a second stent. The goal is to see which method works better for patients like you.
Suwon, Gyeonggi-doAges 19 years+ - NCT06074549Recruiting
DynamX bioadaptor heart artery trial
This trial studies a new type of device called the DynamX Bioadaptor, which is placed inside a blocked heart artery to help it heal and flex naturally. It is designed for people who need a stent (a tiny tube to open a blocked artery) and may offer a more adaptive option than traditional stents.
PöltenAges 18 years+ - NCT06075602Recruiting
Complex and calcified coronary artery disease: a registry study
This study watches how people with complex or calcified heart artery disease are treated (with stents or bypass surgery) and how they do over time. It aims to learn which treatments work best for tough blockages.
Lucerne, Canton of LucerneAges 18 years+ - NCT06186037RecruitingPhase 4
Lower-dose combo vs. higher-dose alone for heart artery disease
This trial compares a lower-dose cholesterol pill (rosuvastatin plus ezetimibe) to a higher-dose version of just rosuvastatin for people with mild to moderate heart artery blockages who have not had a stent or bypass. It aims to see which approach works better and is safer.
Suwon, Gyeonggi-doAges 19 years+ - NCT06218485Recruiting
Comparing two methods to guide heart stenting
This study compares two ways to guide stenting for blocked heart arteries: one uses a pressure wire (FFR) to measure blood flow, and the other uses ultrasound (IVUS) plus a computer estimate of blood flow. The goal is to see which approach leads to better outcomes after stent placement.
BeijingAges 19 years+ - NCT06259019Recruiting
Blood test during heart procedure to find disease markers
This trial uses a special device to take a small blood sample from your heart arteries during a planned procedure. It aims to find unique markers that could help doctors better understand and treat coronary artery disease.
BournemouthAges 18 years+ - NCT06271590Recruiting
Drug-coated balloon for small heart artery blockages
This trial tests a special balloon coated with a drug (sirolimus) to treat blockages in small heart arteries. If the balloon is successful, it may help keep the artery open without needing a permanent stent.
Gilbert, ArizonaAges 18–80 - NCT06338293RecruitingPhase 4
Inclisiran plus statins for fragile heart plaque
This trial tests if adding inclisiran to your current statin can reduce dangerous, rupture-prone plaque in your heart arteries. It may help if you have a moderate blockage with thin-cap plaque and your LDL cholesterol stays high despite statins.
Nanjing, JiangsuAges 18–80 - NCT06373601Recruiting
Testing a drug-coated balloon for small heart arteries
This study tests a drug-coated balloon (DCB) that releases two medicines (sirolimus and paclitaxel) to open blocked small heart arteries. It may help people with stable chest pain or recent, controlled heart events who have a narrowed small vessel.
Mercogliano, Italy/AvellinoAges 18 years+
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Common questions
- Are there clinical trials for coronary artery disease (left main)?
- Yes. Clin2 currently lists 123 recruiting coronary artery disease (left main) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a coronary artery disease (left main) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a coronary artery disease (left main) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.