Clinical trials
Coronary Artery Disease (Left Main) clinical trials
Below are recruiting coronary artery disease (left main) clinical trials, each written for real people, not researchers. We’re tracking 123 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06399692RecruitingPhase 3
Heart treatment study for women with blocked arteries
This trial is comparing two common heart procedures—bypass surgery (CABG) and stents (PCI)—to see which works better for women with blockages in multiple heart arteries. It aims to find the best treatment for women, who are often underrepresented in heart research.
Glendale, CaliforniaAges 18 years+ - NCT06399705RecruitingPhase 3
Comparing bypass surgery vs stenting for minority heart patients
This trial compares two common heart procedures—bypass surgery and stenting—for people with multiple blocked arteries. It focuses on minority groups to find out which treatment works best for them. You will be asked to fill out quality-of-life questionnaires for up to 10 years.
Glendale, CaliforniaAges 18 years+ - NCT06400290Recruiting
Balloon test to find which artery causes chest pain
This study tests a new way to find which blocked heart arteries are causing your chest pain. During a stent procedure, doctors will briefly block each artery to see which one triggers your symptoms. This might help them decide which blockages to treat.
BasildonAges 18 years+ - NCT07596706Recruiting
Comparing two stent techniques for left main branch blockages
This trial compares two ways of placing a stent at the point where the main left artery splits into two branches. It is for people who have a blockage in the very beginning of one of those branches, and it uses advanced drug-eluting stents to see which method works better.
Istanbul, Please SelectAges 18–85 - NCT06489119Recruiting
Studying plaque types in coronary artery disease with advanced imaging
This trial uses advanced imaging (OCT) and single-cell analysis to study different types of plaque in people with coronary artery disease. It aims to understand how these plaque types differ at a cellular level, which could lead to better treatments.
Harbin, HeilongjiangAges 18–85 - NCT06535568Recruiting
Comparing one vs two blood thinners after heart artery balloon treatment
This trial tests whether taking just one blood thinner (clopidogrel) is as safe and effective as taking two (clopidogrel plus aspirin) for older adults or people at high bleeding risk who have had a drug-coated balloon procedure to open blocked heart arteries.
Milan, MIAges Any age - NCT06551662Recruiting
Balloon vs. stent for split artery blockages
This trial compares two ways to open a blocked artery that splits into two branches (a bifurcation): using a balloon coated with medicine (drug-coated balloon, or DCB) versus a drug-eluting stent (DES). The goal is to see which approach works better for patients with this type of blockage.
MilanAges 18 years+ - NCT06559332Recruiting
Heart artery checks during aortic valve replacement
This study tests different ways to check for blocked heart arteries in patients getting a new aortic valve through a tube in the leg. It aims to find the best approach to guide treatment.
BernAges 70 years+ - NCT07091682Recruiting
A trial of a dissolvable heart stent for long blockages
This trial tests a new type of stent made from magnesium that slowly dissolves over time. It is for people who have a long blockage in a heart artery that has not been treated before and may be a good option for those who are stable and have not had a recent heart attack.
ErfurtAges 18–80 - NCT01311323Recruiting
Testing heart procedures to fully open blocked coronary arteries
This trial compares different ways to treat serious heart artery blockages in people with a recent heart attack or unstable chest pain. It aims to see which revascularization approach works best when doctors think the heart arteries can be fully treated.
Chrzanów, MalopolskaAges 18 years+ - NCT06603363Recruiting
Statin effects on heart artery plaques seen on CT scans
This trial studies how short-term statin therapy changes plaque buildup in heart arteries. It uses CT scans to see if statins can make plaques more stable and reduce heart risks.
Budapest, BudapestAges 45–75 - NCT06606821RecruitingPhase 4
Tirzepatide for heart health in people with overweight or obesity
This trial tests the weight‑loss medication tirzepatide (Mounjaro) in people who are overweight or have obesity and have stable coronary artery disease. The goal is to see if tirzepatide can reduce dangerous fatty plaque in heart arteries.
CopenhagenAges 18 years+ - NCT06710210Recruiting
Hybrid scaffold-balloon vs standard stent for long blockages
This trial tests a new way to treat long, narrow blockages in heart arteries. Instead of using a standard permanent metal stent, doctors will combine a temporary scaffold with a special balloon that releases medication. The goal is to see if this approach works as well as or better than the usual metal stent.
Geneva, Canton of GenevaAges 18 years+ - NCT06736665Recruiting
Comparing two ways to treat hardened calcium in heart arteries
This trial compares two techniques (orbital atherectomy and intravascular lithotripsy) to break up tough calcium deposits in the heart's arteries that can block blood flow. If you have a calcified nodule and are having a non-emergency procedure to open a blocked artery, this study may help guide which method works best.
Alicante, AlicanteAges 18 years+ - NCT06767345RecruitingPhase 4
Comparing two cholesterol medicines for plaque stabilization
This study compares two ways to lower cholesterol and stabilize artery plaque in people with coronary artery disease who are having a stent procedure. It tests whether a moderate statin plus ezetimibe works as well as a high-intensity statin alone for stabilizing plaque.
Seoul, SeoulAges 18 years+ - NCT06814587Recruiting
New imaging for heart muscle damage after a heart attack
This study uses special imaging scans (MRI and PET) to look at the health of the heart muscle in people with advanced heart failure caused by blocked arteries. The goal is to better predict recovery after bypass surgery.
Dallas, TexasAges 20–80 - NCT06844942Recruiting
Improving heart artery imaging for chest pain diagnosis
This trial uses a special camera called OCT to take detailed pictures of the heart's arteries. It aims to see if these pictures help doctors better understand blockages and decide on treatment for stable chest pain.
Warsaw, Mazowieckie VoivodenshipAges 18 years+ - NCT06855537RecruitingPhase 4
Stent for vulnerable plaques in heart patients
This trial tests whether implanting stents in non-obstructive, high-risk plaques (thin-capped fatty plaques) can prevent future heart attacks. It is for people who have already had treatment for a recent heart attack or unstable angina and have additional plaques that are not severely blocking blood flow but are vulnerable.
Beijing, Beijing MunicipalityAges 18–80 - NCT06954714Recruiting
Balloon vs stent for new heart blockages
This trial compares two treatments for new blockages in heart arteries: a drug-coated balloon (a tiny balloon that delivers medicine) versus a drug-eluting stent (a small mesh tube that releases medicine). The study hopes to see which approach keeps the artery open longer and is safer over time.
Busan, BusanAges 19 years+ - NCT07009418Recruiting
CT scan vs. usual care after heart stent or balloon treatment
This trial tests whether a CT scan of the heart arteries is a safe and effective alternative to standard follow-up tests in people who have had a stent or drug-coated balloon placed in a high-risk coronary artery. It may help reduce the need for additional invasive procedures.
Bucheon-siAges 19 years+ - NCT07010094Recruiting
Shockwave balloons for hardened heart artery blockages
This trial tests a special balloon that uses shock waves to crack calcium in heart arteries, making it easier to place a stent. It is for people with chest pain or signs of heart strain due to a single, severely blocked artery with dense calcium.
Fujian, XiamenAges 18–85 - NCT07022587Recruiting
Dissolving stent with drug for blocked heart arteries
This trial tests a stent that slowly dissolves after opening a blocked heart artery, releasing a drug to prevent reclogging. It may help people with narrowing in one or two spots that are not too hard or twisted.
Xi'an, ShannxiAges 18–75 - NCT07114393Recruiting
Better imaging to guide complex heart artery procedures
This study looks at whether using advanced imaging inside the heart arteries during complex procedures leads to better outcomes compared to current standard practice. If you have had a complex angioplasty (PCI) and your data is in a national heart registry, you may be included.
Eindhoven, North BrabantAges 18 years+ - NCT07116083Recruiting
Study of a new way to check branch blockages after stent placement
This trial looks at a new method called µQFR to check if there are any significant blockages in the side branches of heart arteries after a single stent has been placed. It aims to see if this method can help doctors decide if more treatment is needed.
Shanghai, Shanghai MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for coronary artery disease (left main)?
- Yes. Clin2 currently lists 123 recruiting coronary artery disease (left main) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a coronary artery disease (left main) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a coronary artery disease (left main) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.