Clinical trials
Crohn’s disease clinical trials
A type of inflammatory bowel disease causing inflammation of the digestive tract. We’re tracking 334 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06958536RecruitingPhase 2
Testing a new drug for moderate to severe Crohn's disease
This study tests an experimental drug called SAR442970 for people with moderate to severe Crohn's disease who haven't had success with standard treatments or biologics. The goal is to see if it can reduce inflammation and improve symptoms.
Tucson, ArizonaAges 18–75 - NCT07078994RecruitingPhase 2
Study of a new drug for moderate to severe Crohn's disease
This trial tests a new medicine called BCD-261 for people with moderate to severe Crohn's disease that has not responded well to other treatments. It aims to see if the drug can reduce symptoms and inflammation.
Barnaul, Altayskiy KrayAges 18–75 - NCT07184944RecruitingPhase 3
Study of Duvakitug for moderate to severe Crohn's disease
This study tests a new drug called duvakitug to see if it can help maintain improvement in people with moderate to severe Crohn's disease. It's for patients who have already responded to treatment in a previous study.
Colorado Springs, ColoradoAges 16–80 - NCT07545317Recruiting
IL-23 Inhibitors for Active Crohn's Disease
This study follows patients with moderate-to-severe Crohn's disease who are starting a newer type of biologic medication called IL-23 inhibitors (guselkumab or risankizumab). Researchers want to understand how well these drugs work in real-world clinical practice and compare their effectiveness to other treatments.
Guangzhou, GuangdongAges 18–75 - NCT07310095RecruitingPhase 4
Study of Guselkumab for Crohn's Disease in Chinese Patients
This trial tests a new treatment called guselkumab for people with active Crohn's disease who have tried and stopped responding to another treatment called ustekinumab. It aims to see if guselkumab can help control symptoms like belly pain and loose stools.
GuangzhouAges 18 years+ - NCT07184931RecruitingPhase 3
Testing duvakitug for active Crohn's disease
This study tests a new drug called duvakitug for people with moderately to severely active Crohn's disease who haven't responded well to other treatments. It aims to see if the drug can reduce symptoms and improve quality of life.
Peoria, ArizonaAges 16–80 - NCT00692939RecruitingPhase 1/Phase 2
Stem cell transplant for people with Crohn’s who need new options
This trial studies whether an “autologous” stem cell transplant (using your own cells) can improve Crohn’s disease that has not responded to standard treatments. It may help people who have ongoing, hard-to-control Crohn’s even after medicines and/or who have complications that make surgery risky.
Pittsburgh, PennsylvaniaAges 10–60 - NCT07504510Recruiting
Exclusive liquid nutrition for active Crohn's disease
This trial tests whether a special liquid-only diet (exclusive enteral nutrition) can help people with active Crohn's disease, including those with complications like fistulas or narrowing of the intestine. It aims to improve nutrition and reduce disease activity without medication.
Guangzhou, GuangdongAges 18 years+ - NCT07531342Recruiting
Brain Stimulation and Diet for Severe Crohn's Disease
This study tests whether repetitive transcranial magnetic stimulation (a non-invasive brain treatment) combined with an anti-inflammatory diet can help people with severe, treatment-resistant Crohn's disease feel better. The brain stimulation uses magnetic pulses on the scalp to reduce inflammation and improve symptoms.
Giza, Giza GovernorateAges 40–60 - NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+ - NCT06553053Recruiting
Acupuncture to prevent Crohn's disease relapse
This trial tests if acupuncture can help people with Crohn's disease stay in remission longer and avoid flare-ups. If you are in remission but have had frequent relapses, this study may be for you.
ShanghaiAges 16–75 - NCT07556718RecruitingPhase 2
Amitriptyline for IBS-like Symptoms in Stable Crohn's Disease
This study tests whether a medication called amitriptyline can help reduce belly pain and bowel problems in people whose Crohn's disease is well-controlled. Amitriptyline is an older antidepressant that may help with pain and bowel symptoms even when inflammation is quiet.
Ann Arbor, MichiganAges 18–65 - NCT07246460Recruiting
Ultrasound and protein tests to see if guselkumab works for Crohn's
This study tests whether guselkumab (a targeted drug) can effectively treat Crohn's disease in the ileum (last part of the small intestine). You will have ultrasound scans and blood tests to measure your response, which may help find the right dose and monitor for bowel healing.
Calgary, AlbertaAges Up to 80 years - NCT04779320RecruitingPhase 3
Vedolizumab for teens with moderate to severe Crohn's
This trial tests vedolizumab to treat children and teens with moderate to severe Crohn’s disease when standard treatments haven’t worked or caused side effects. It may help reduce gut inflammation and symptoms and help some patients stay healthier over time.
Phoenix, ArizonaAges 2–17 - NCT06764615RecruitingPhase 2
Long-term study of TAK-279 for ulcerative colitis and Crohn's disease
This study is for people who already completed 52 weeks of treatment with TAK-279 for ulcerative colitis or Crohn's disease and saw improvement. It gives them the option to continue the medication long-term to see if the benefits last.
Glen Burnie, MarylandAges 18–75 - NCT02421705Recruiting
Brain-gut sensitivity study in IBS and inflammatory bowel disease
This study checks how sensitive your gut is to normal stimuli in people with IBS, ulcerative colitis, Crohn’s disease, and in healthy volunteers. Results may help researchers understand why some people feel more abdominal discomfort and how that connects to inflammatory bowel conditions.
Leuven, Vlaams-BrabantAges 18–65 - NCT07522528Recruiting
Biologics and Nutrition Treatment for Active Crohn's in Young People
This study tests whether combining biologic medicines (TNF-alpha inhibitors like infliximab or adalimumab) with a special nutrition plan helps young people with active Crohn's disease feel better. The nutrition plan may include drinking special formula drinks instead of regular food (or alongside some regular food).
AberdeenAges 6–18 - NCT07483073RecruitingPhase 2
Study of new drugs for moderate to severe ulcerative colitis or Crohn's disease
This trial is testing multiple new drugs for people with moderate to severe ulcerative colitis or Crohn's disease who have not had success with at least one standard treatment. The goal is to find a better option that can help control symptoms and inflammation.
Scottsdale, ArizonaAges 18–80 - NCT04740541Recruiting
Diet study for adult men with Crohn’s disease
This study looks at how a specific amino-acid (threonine) diet affects adults with Crohn’s disease and signs of intestinal inflammation. It may help researchers understand what dietary protein needs could support more stable disease.
Toronto, OntarioAges 18–49 - NCT05903066Recruiting
MRI-based healing study in Crohn’s disease
This study looks at how Crohn’s disease healing shows up on a special MRI (MRE) and tries to better define what “healed” means. It may help your care team track healing more accurately, especially inside the bowel.
LiègeAges 18–75 - NCT06690632Recruiting
Water preparation for MRI in Crohn's disease
This trial tests if drinking water before an MRI scan works just as well as the usual bowel preparation for people with Crohn's disease. If you need an MRI to check on your Crohn's, this study might be an option for you.
ToulouseAges 18 years+ - NCT06856044Recruiting
Safety of a New Surgical Method for Crohn's Disease on Biologics
This study tests whether a special surgical technique (mesentery-embedding) is safe for people with Crohn's disease who need ileocolic surgery and are already on a biologic medication. It aims to see if this method can help reduce complications.
MontpellierAges 18 years+ - NCT07111715Recruiting
AI vs. standard reading for suspected Crohn disease
This study tests whether an artificial intelligence (AI) system can help doctors find signs of Crohn's disease better than standard reading of capsule endoscopy images. It is for people who have symptoms that might be Crohn's but whose colonoscopy didn't clearly show the problem.
BresciaAges 18–75 - NCT07289672Enrolling by invitation
Food limits in Crohn's and colitis
This study looks at how diet affects people with Crohn's disease or ulcerative colitis who have moderate inflammation. It aims to understand if certain foods make symptoms worse or better.
MalmöAges 18 years+
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Common questions
- Are there clinical trials for crohn’s disease?
- Yes. Clin2 currently lists 334 recruiting crohn’s disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a crohn’s disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a crohn’s disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.