Clinical trials
Cystic Fibrosis clinical trials
Below are recruiting cystic fibrosis clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06683092Recruiting
Restarting triple therapy with close monitoring for side effects
This trial tests whether carefully restarting a triple-combination CFTR modulator (VTD) is safe and helpful for people with cystic fibrosis who had to stop or change Trikafta because of mental health side effects or liver injury. You will be closely monitored with surveys and daily diaries to ensure your safety.
Birmingham, AlabamaAges 6 years+ - NCT06242795RecruitingPhase 4
Hypertonic saline for non-cystic fibrosis bronchiectasis
This trial tests whether inhaling a saltwater solution (hypertonic saline) twice a day for 12 weeks can help people with bronchiectasis who have a chronic cough and have had flare-ups in the past. It aims to see if this treatment reduces mucus and improves quality of life.
Chapel Hill, North CarolinaAges 18 years+ - NCT06654752Recruiting
Simpler treatment for lung flare-ups in kids with CF
This study tests a streamlined approach to managing sudden lung symptoms (pulmonary exacerbations) in children with cystic fibrosis. It aims to see if a simpler treatment plan works as well as standard care, which could mean less time in the hospital and fewer disruptions to daily life.
Birmingham, AlabamaAges 3–18 - NCT06603246RecruitingPhase 1
Study of inhaled GDC-6988 for mucus lung diseases
This study tests an inhaled medicine (GDC-6988) to see if it is safe and helps clear mucus from the lungs in people with mucus-related lung diseases like chronic bronchitis, COPD, or bronchiectasis. You may qualify if your lung function is fairly stable and you produce daily mucus.
Birmingham, AlabamaAges 18 years+ - NCT06504589Recruiting
Study for CF treatments for people without modulators
This study tests new treatments for cystic fibrosis in people who cannot take or choose not to take current CFTR modulators. It aims to find better options for managing CF.
Birmingham, AlabamaAges 12 years+ - NCT06512064Recruiting
Breath sound analysis for lung health
This study tests a new device that listens to your breathing to check how well your lungs are working. It might help diagnose lung conditions without the need for forceful blowing tests, making it easier for patients.
Indianapolis, IndianaAges 8–70 - NCT06339593RecruitingEarly Phase 1
Using MRI to Monitor CF Lung Health
This study uses MRI scans to monitor lung health in teens and young adults with cystic fibrosis who are taking Trikafta. It aims to find better ways to track how the disease affects the lungs over time.
Cincinnati, OhioAges 12–21 - NCT06262282Enrolling by invitation
Phage therapy for stubborn NTM infection in cystic fibrosis
This trial tests whether a special virus therapy (phage) can help clear stubborn NTM lung infections in people with cystic fibrosis who have been on antibiotics for over a year without success. Participants will continue their antibiotics while receiving the phages.
Birmingham, AlabamaAges 6 years+ - NCT06273566Recruiting
Validating a questionnaire for adults with cystic fibrosis
This study is checking if a French questionnaire about physical therapy and daily life works well for people with cystic fibrosis. You would answer questions to help doctors better understand your experience.
CaenAges 18–100 - NCT04294043RecruitingPhase 1
Gallium IV study for adults with cystic fibrosis and NTM lung infection
This Phase 1 study tests whether an IV medicine called gallium can treat hard-to-treat lung infections (NTM) in adults with cystic fibrosis. It is mainly for people who have not been treated yet for NTM or who have NTM that has not cleared despite antibiotics.
Birmingham, AlabamaAges 18 years+ - NCT06147414Recruiting
Blood test for genetic disorders in pregnancy
This study tests a safer blood test to check for certain genetic disorders during pregnancy, instead of an invasive procedure like amniocentesis. It's for pregnant women who are at risk of passing on a known genetic condition.
ParisAges 18 years+ - NCT01851642Recruiting
Study how lung disease affects white blood cells
This study looks at how lung disease changes a type of blood cell called white blood cells. It may help researchers understand what’s happening in the lungs and how to better monitor or treat lung problems.
Gainesville, FloridaAges 18 years+ - NCT05704036RecruitingPhase 4
Estrogen use and bone health in women with cystic fibrosis
This observational study looks at how taking (or not taking) estrogen affects bone health in women with cystic fibrosis (CF). If you may have low estrogen, it also explores whether estrogen levels and symptoms relate to bone density over time.
Baltimore, MarylandAges birth–100 years - NCT06045702Recruiting
Study of CFTR gene in epididymal cells from surgery
This study collects a small tissue sample from the epididymis during planned surgery. The sample is used to study how the CFTR gene works, which may help understand fertility problems in men with cystic fibrosis.
BrestAges 18 years+ - NCT05860803Recruiting
Breathing training plus exercise to improve breathing capacity
This study looks at whether breathing exercises combined with exercise training can improve how much and how well you can breathe during activity in people with non-cystic fibrosis bronchiectasis. It may help by improving breathing efficiency and exercise tolerance, but you must be stable and healthy enough to safely exercise.
Jacksonville, FloridaAges 21–80 - NCT05727852Enrolling by invitation
Breath and heart tests to study lung disease stiffness
This study uses breath analysis and heart/electrical heart testing to look at how stiff the arteries are in people with long-term lung conditions. It may help researchers better understand lung disease effects on the cardiovascular system.
MoscowAges 18 years+ - NCT05686837Enrolling by invitation
Study of how lung bacteria spreads in people with cystic fibrosis
This trial follows people with cystic fibrosis to better understand how “nontuberculous mycobacteria” (a type of lung germ) spreads between healthcare visits and care settings. It may help improve future prevention and monitoring strategies for CF patients who have had these bacteria.
Denver, ColoradoAges 1 month–99 years - NCT05359991Recruiting
Exercise study in children and teens with lung or blood conditions
This study tests how safe and effective a structured exercise program is for children and teens. It also compares results between children with sickle cell disease, cystic fibrosis, and healthy peers (and some teens after COVID-19 infection).
Irvine, CaliforniaAges 10–17 - NCT04793867Recruiting
MRI study of lung differences in cystic fibrosis and bronchiectasis
This study uses MRI scanning to better understand how the lungs differ in people with cystic fibrosis (CF) and in people with non-CF bronchiectasis. The results may help doctors understand disease changes over time and guide future care, especially for children and teens.
Cincinnati, OhioAges 5–100 - NCT04624490RecruitingPhase 1
Lung function MRI using a special gas in volunteers
This Phase 1 study tests a lung scan that uses a special gas and MRI to measure how well your lungs work. It includes healthy volunteers and people with lung disease to see how well the scan works and how safe it is.
Kansas City, KansasAges 3 years+ - NCT04509050Recruiting
Testing a highly effective CF medicine in young children
This study looks at how well a highly effective cystic fibrosis (CF) medicine works in infants and young children, and what biological changes it causes. It may help families understand whether the medicine improves CF function and related measures early in life.
Birmingham, AlabamaAges Up to 10 years - NCT04579211Enrolling by invitation
Urine testing to skip repeated NTM sputum checks in cystic fibrosis
This study looks at whether a urine test (instead of repeated sputum—mucus—from the lungs testing) can help determine who with cystic fibrosis does not have certain lung germs called NTM. If the urine test works, it could reduce the need for lung sample testing while still keeping people safe.
Denver, ColoradoAges 18 years+ - NCT03587961RecruitingEarly Phase 1
Personalized testing to find the best CF medicine for you
This early study tests an individualized approach (“theratyping”) to match your cystic fibrosis (CF) to the CFTR medicine that may work best for your specific genetic change. It may help find a more tailored treatment plan and see how your body responds, while using medicines that are already approved for some people with CF.
Birmingham, AlabamaAges 6 years+ - NCT03161808Recruiting
CF rare mutation blood and tissue sample collection study
This study collects cells from people with cystic fibrosis (CF) caused by rare CFTR gene changes. The goal is to build a cell bank for future research, which may help scientists develop better tests and treatments for rare CF types.
Birmingham, AlabamaAges 17 years+
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Common questions
- Are there clinical trials for cystic fibrosis?
- Yes. Clin2 currently lists 148 recruiting cystic fibrosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cystic fibrosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cystic fibrosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.