Clinical trials
Depression Disorders clinical trials
Below are recruiting depression disorders clinical trials, each written for real people, not researchers. We’re tracking 669 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05497115Recruiting
Care model to improve access to mental health after trauma
This trial tests a practical care plan to help people get mental health support after a traumatic injury, especially if screening suggests risk for PTSD or depression. It may help you connect faster to the right kind of treatment after your injury.
Washington, VirginiaAges 16 years+ - NCT05437705Recruiting
Brain scan and stimulation study for low mood
This study uses brain imaging (MRI) and a brain-stimulation method (TMS) to understand and possibly change brain patterns linked with low mood. You may be eligible if you have moderate to severe depression symptoms and can safely complete the scans and stimulation sessions.
Philadelphia, PennsylvaniaAges 18–65 - NCT05327699RecruitingEarly Phase 1
Ketamine study for depression with reduced pleasure
This early-phase study tests whether ketamine can help people with major depression who have trouble feeling pleasure. It also studies how the brain may change in response to stress, to better understand who might respond to treatment.
Atlanta, GeorgiaAges 18–65 - NCT05004987RecruitingPhase 4
Study brain and blood changes in older adults with depression
This study looks at how a brain protein linked to Alzheimer’s disease changes over time in older adults who have major depression but no major memory problems. It involves brain scans, blood and urine tests, and a spinal fluid sample to better understand the connection between depression and brain aging.
New York, New YorkAges 60 years+ - NCT04956016Recruiting
Compare two rTMS treatments for moderate to severe depression
This study tests whether a classic type of brain stimulation (rTMS) works better or the same as a deeper version for depression that keeps coming back or is ongoing. You may be offered one of the two stimulation options to see which helps reduce depressive symptoms.
PoitiersAges 18 years+ - NCT04877977Recruiting
Long-Term Follow-Up for People With Mood Disorders
This study follows people with mood disorders over a long time to better understand how symptoms and functioning change. You may be able to join if you already agreed to take part in an earlier mood/anxiety study and you meet basic participation needs.
Bethesda, MarylandAges 18–99 - NCT04923685Recruiting
Study looks at blood markers linked to childhood trauma and suicide risk
This study checks whether tiny genetic signals in blood (microRNAs) are linked to childhood maltreatment and thoughts or risk of suicide, especially in people with major depression. It may help researchers understand biological clues that could someday guide better care.
Birmingham, AlabamaAges 18–60 - NCT02604277Recruiting
Study of suicidal behavior in people with bipolar disorder
This study looks at suicidal thoughts or behaviors in people diagnosed with bipolar disorder. It may help researchers understand what leads to suicidal risk and how to better support safety and treatment.
Atlanta, GeorgiaAges 18–64 - NCT04040062Enrolling by invitation
Tested deep brain–stimulating treatment for hard-to-treat depression
This study tests a specialized type of magnetic brain stimulation (spectral TMS) to treat severe major depression when standard treatments haven’t worked. You may be eligible if you’ve tried several antidepressants and other add-on treatments but still have symptoms.
Los Angeles, CaliforniaAges 18–65 - NCT05866991Recruiting
Study tracking sleep and mood in depression
This study looks at people with a current episode of major depression and measures sleep and daily body-clock patterns, along with other mental health symptoms. They may help researchers better understand how sleep and mood changes relate, which could improve future care.
Paris, ParisAges Any age - NCT05651295Recruiting
Smartphone precision study to improve emotion regulation
This trial tests a precision approach delivered through a smartphone to better track and target how you manage strong emotions. It may help if you have ongoing difficulty regulating emotions day to day.
Columbus, OhioAges 18 years+ - NCT06142955Recruiting
TMS therapy for depression in autism spectrum disorder
This study tests whether transcranial magnetic stimulation (TMS), a noninvasive brain stimulation technique, can help treat depression in people with autism spectrum disorder. It may help if you are between 18 and 40, have autism and depression, and are not taking medications that could interfere.
New Haven, ConnecticutAges 18–40 - NCT07721753Recruiting
Online exercise and therapy for breast cancer mood
This study tests an online program that combines fun video-game exercises with talk therapy to help breast cancer patients who feel depressed or anxious. It takes place in Malaysia and is for Chinese-speaking adults.
Xinxiang, HenanAges 18 years+ - NCT06706323Recruiting
Depression after heart surgery study
This study looks at depressive symptoms in people who have had heart bypass surgery. It aims to understand how patients feel emotionally after surgery and may help improve care.
ZurichAges 18–90 - NCT07413874Recruiting
Music therapy over video for depression and hormone disorder
This trial tests if telehealth music therapy can help adults who have both an endocrine autoimmune disease and depression. You'll join sessions from home using Zoom.
Boone, North CarolinaAges 18–65 - NCT03678194Recruiting
Smartphone app tool for doctors managing daily depression
This trial tests a smartphone app that helps doctors manage depression in everyday life. It may help improve how care is tracked and adjusted soon after starting antidepressant treatment.
BordeauxAges 18–65 - NCT07852728RecruitingPhase 2
Oxygen therapy for first responders after head injuries
This trial tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve thinking, mood, and overall well-being in first responders who have had a traumatic brain injury and still have symptoms. If you are a first responder dealing with ongoing brain injury symptoms, this study could help you find new ways to feel better.
Boise, IdahoAges 18–75 - NCT07653022Enrolling by invitation
Turkish symptom questionnaire for Turkish speakers with language barriers
This study tests a Turkish version of a questionnaire for Turkish-speaking patients who have psychological complaints but face language barriers. It aims to help doctors better understand their symptoms.
Jette, Brussels CapitalAges 18 years+ - NCT07613008Recruiting
Mobile app to prevent perinatal depression and anxiety
This study tests a personalized smartphone app designed to help pregnant women and their partners prevent depression and anxiety during pregnancy and after birth. Participants use the app for support and receive check-ins from healthcare providers.
Mairena del Aljarafe, SevillaAges 18 years+ - NCT07556692Recruiting
Home Brain Stimulation for Bipolar Depression
This study tests whether a device you use at home can help reduce depression symptoms in people with bipolar disorder. The device uses gentle electrical stimulation on the scalp to potentially improve mood.
LondonAges 18 years+ - NCT07544563Recruiting
Brain Activity During Sound Testing
This study measures how your brain responds to sounds in a specially designed quiet room. Researchers want to understand how epilepsy affects sound processing, which could help improve treatment in the future.
ParisAges 18 years+ - NCT07503951Recruiting
Talking therapy for inpatients in psychiatric care
This trial tests whether cognitive behavioral therapy (CBT) works for people staying in a psychiatric hospital. You should be staying for at least three days and able to talk through your thoughts and feelings.
StockholmAges Any age - NCT07409298Enrolling by invitation
AI support for breast cancer patients on CDK4/6 inhibitors
This trial tests whether an AI-powered management program can improve mental health and daily habits for people with HR+/HER2- breast cancer who are taking CDK4/6 inhibitor pills at home. It is designed to help you feel supported and stay on track with your rehabilitation plan.
TianjinAges 18–80 - NCT07280416Recruiting
Sleep changes in first year after cancer diagnosis
This study follows people who are newly diagnosed with cancer to see how their sleep changes during the first year. It looks at whether treatments like chemo or immunotherapy affect insomnia.
Le Puy-en-VelayAges 18–80
Hear when a new Depression Disorders trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for depression disorders?
- Yes. Clin2 currently lists 669 recruiting depression disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.