Clinical trials
Depression Disorders clinical trials
Below are recruiting depression disorders clinical trials, each written for real people, not researchers. We’re tracking 669 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05603104RecruitingPhase 3
Medication intensification after first treatment failure in mood and psychosis
This Phase 3 study tests a stronger medication approach after your first current treatment hasn’t worked well enough. It targets people with schizophrenia, major depressive disorder, or bipolar depression who still have significant symptoms and life impact.
Ramat GanAges 18–70 - NCT05543083Recruiting
Therapy plus exercise for teens at risk of type 2 diabetes
This trial tests whether a combination of coaching (cognitive-behavioral therapy) and exercise can improve mood and help teens who are at higher risk for type 2 diabetes. It may be especially helpful if you’re dealing with depression symptoms and a family history of type 2 diabetes.
Aurora, ColoradoAges 12–17 - NCT04984512RecruitingPhase 2/Phase 3
Testing mitizodone tablets for major depression symptoms
This trial studies whether mitizodone phosphate tablets can improve symptoms of major depressive disorder (MDD). It also checks the treatment’s safety, including mood and physical health effects.
Dongguan, GuangdongAges 18–65 - NCT04572321Enrolling by invitation
Teen depression and suicide research study for youth
This study looks at depression and suicidal thoughts or behaviors in children and teens. It may help researchers better understand these risks and improve supports for young people.
Dallas, TexasAges 8–20 - NCT04480918Recruiting
Registry for people with depression or bipolar to receive psychiatry care
This is a patient registry that enrolls people being evaluated for treatment options from an Interventional Psychiatry Service. It helps track patients with depression, bipolar disorder, or treatment-resistant OCD who are suitable for these psychiatry treatments.
Iowa City, IowaAges 18–99 - NCT04159662Recruiting
Brain scans to study thinking in schizophrenia and depression
This study uses brain imaging to better understand how thinking works in people with schizophrenia or major depression. Your results may help researchers learn what brain patterns match different thinking and symptoms.
Ottawa, OntarioAges 18–60 - NCT03065335RecruitingPhase 1
Ketamine plus brain imaging to study response in depression
This early-stage study tests how ketamine given once and then repeatedly may change brain signals and related biomarkers in people with major depression. If you’re eligible, the team will use brain imaging and assessments to see who responds and why.
Bethesda, MarylandAges 18–65 - NCT07768397Recruiting
Comparing two brain-stimulation schedules for depression
This study tests two different schedules of a treatment called theta burst stimulation, which uses magnetic pulses to gently stimulate the brain. It aims to find out if the faster schedule works better than the standard one for people with major depression.
Ho Chi Minh CityAges 18–65 - NCT05644301RecruitingPhase 3
Blood-marker guided add-on treatment for major depression
This study tests whether doctors can choose the best add-on immune-related treatment for people with major depressive disorder by using inflammation blood tests. It’s meant for people whose depression has not improved enough with their current antidepressant.
Duffel, AntwerpenAges 18–65 - NCT07684911Recruiting
Long-term effects of TMS for depression
This study looks at how well the benefits of transcranial magnetic stimulation (TMS) last over time for people with depression that didn't get better with other treatments. It also uses brain scans to find markers that might predict who will keep doing well.
RennesAges 18 years+ - NCT06668688Recruiting
Testing a school mental health website
This study looks at how users naturally interact with a website called 'ich Bin Alles @Schule' (I Am Everything @school). It aims to understand the user experience, which may help improve the site for students.
MunichAges Any age - NCT07633080Recruiting
Magnesium supplement added to antidepressants for depression
This study tests whether adding magnesium bisglycinate (a mineral supplement) to your current antidepressant medication can help improve depression symptoms. Researchers want to see if this combination works better than antidepressant alone.
Bhubaneswar, OdishaAges 18–65 - NCT07523048RecruitingPhase 2
Dextromethorphan-Bupropion for Moderate-to-Severe Depression
This study tests a combination medication (dextromethorphan plus bupropion) to see how it affects brain activity in people with moderate-to-severe depression. Researchers use brain imaging (fMRI) to understand how the drug works and whether it may help relieve depression symptoms.
Toronto, OntarioAges 18–65 - NCT06695767Recruiting
Behavioral therapy for epilepsy and depression in veterans
This trial tests a special therapy program for veterans who have both epilepsy and major depression. It uses talk therapy and text message support to help improve mood and seizure control.
Houston, TexasAges 18 years+ - NCT07474363Recruiting
Depression differences between men and women
This study looks at how depression affects men and women differently, including symptoms, strength to cope (resilience), and feelings of stigma. It aims to understand these differences to improve treatment.
Eskişehir, EskişehirAges 18–65 - NCT07416747Recruiting
Probiotic supplement with talk therapy for mild to moderate depression
This study tests whether adding a probiotic supplement to supportive talk therapy helps improve symptoms of mild to moderate depression. It may offer an additional option for people who are not currently taking antidepressant medication.
CréteilAges 18–65 - NCT07398365Recruiting
Medical study of psychiatry inpatients
This study looks at the medical and mental health patterns of adults admitted to general adult psychiatry wards. It aims to better understand their health needs.
Livingston, West LothianAges 18–65 - NCT04637620RecruitingPhase 2
NMDA-based treatment study for major depression
This Phase 2 trial tests whether an NMDA-targeted treatment can improve symptoms of major depressive disorder (MDD). You may be able to join if your depression diagnosis and symptom score fit, and you meet several safety and study-following requirements.
TaichungAges 18–55 - NCT05136755RecruitingPhase 2
NMDA treatment for depression that did not improve
This trial studies an NMDA-based treatment for people with major depressive disorder who did not respond to at least one antidepressant. It may help by changing brain signaling linked to depression symptoms.
TaichungAges 18–65 - NCT05441969Recruiting
Brain stimulation study for major depression symptoms
This trial studies a way to change how excitable the brain is (through in-person brain stimulation) in people with major depression. It may help understand new treatments or symptom patterns that could be useful for major depression.
LisbonAges 18–65 - NCT07276997RecruitingPhase 2
Study of Icalcaprant for major depressive disorder
This trial tests an oral medication called icalcaprant for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms and what side effects may occur.
Dothan, AlabamaAges 18–65 - NCT06844058Recruiting
Religious vs. standard hypnosis for anxiety and depression
This study compares two types of hypnosis (one that includes Islamic themes and one that follows a standard approach) to see which works better for anxiety and depression. It is designed for Muslim adults who are feeling stressed but do not have a formal mental health diagnosis.
IstanbulAges 18–65 - NCT05435222Recruiting
Male-only therapy program for major depression
This study tests a counseling/psychotherapy program designed specifically for men with major depression. If you qualify, you may be offered this structured therapy and followed to see whether it helps depressive symptoms.
Zurich, Canton of ZurichAges 25–50 - NCT07226661RecruitingPhase 2
Study of an investigational drug for depression
This trial tests an investigational medication for adults with major depressive disorder who are currently taking an antidepressant but still have symptoms. It aims to see if adding this new drug can improve mood better than a placebo.
Garden Grove, CaliforniaAges 18–70
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Common questions
- Are there clinical trials for depression disorders?
- Yes. Clin2 currently lists 669 recruiting depression disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.