Clinical trials
Depression Disorders clinical trials
Below are recruiting depression disorders clinical trials, each written for real people, not researchers. We’re tracking 669 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07204314RecruitingPhase 3
Study of vortioxetine for teens with depression in Japan
This trial tests whether vortioxetine helps reduce symptoms of major depression in Japanese teenagers aged 12-17. It compares the study drug to a placebo to see if it is safe and effective.
Nagoya, Aichi-kenAges 12–17 - NCT07211750Recruiting
Integrated care for older adults with depression and multiple health conditions
This trial tests a new integrated care program for older adults who have depression or bipolar disorder along with at least two other long-term physical health problems. The program aims to bring together your doctors and psychiatrist to improve your overall health.
LeuvenAges 65 years+ - NCT07180537Recruiting
Health course for joint and mood conditions
This study tests an online health course that helps improve diet and self-care to support cell health and wellbeing. It is for people with certain rheumatological conditions like rheumatoid arthritis, lupus, or psoriatic arthritis, who also have mood concerns.
Iowa City, IowaAges 18–100 - NCT06958692RecruitingPhase 3
Testing a new antidepressant combination for depression
This study tests a new combination of two medications (dextromethorphan and bupropion) as a treatment for major depressive disorder. It may be an option if you have not already tried many antidepressants that didn't work.
Beijing, Beijing MunicipalityAges 18–65 - NCT07139834RecruitingPhase 1
Memory and mood study for depression
This study tests how a medication called memantine affects memory and mood in people with major depression who are not currently taking antidepressants. It involves MRI scans and may help find new ways to treat depression.
New York, New YorkAges 18–50 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Phoenix, ArizonaAges 18–64 - NCT07104916RecruitingPhase 2
Mindfulness and psilocybin therapy for PTSD
This study tests whether a combination of mindfulness training and a single dose of psilocybin can help reduce PTSD symptoms. It is for people with moderate-to-severe PTSD who are not on certain medications and do not have major health problems.
Columbus, OhioAges 21–65 - NCT06592833RecruitingPhase 2
Psilocybin with or without pimavanserin for depression
This study tests whether combining psilocybin (a psychedelic substance) with pimavanserin (a medication that may help reduce side effects) works better than psilocybin alone for treating major depressive disorder. It may help people who have not responded well to other treatments.
New York, New YorkAges 21–80 - NCT07080489Recruiting
Decision-making brain activity study for adults
This study uses brain imaging to understand how the prefrontal cortex helps with decision-making. Researchers are looking at healthy adults and people with mild to moderate depression to see if decision-making differs between groups.
BernAges 20–75 - NCT07002684Recruiting
Esketamine study for depression
This trial tests how treatment with esketamine affects metabolism in people with depression. It may help if you have not responded to at least two standard antidepressants.
ZagrebAges 18–70 - NCT06976697Recruiting
Home-based tDCS for major depression
This trial tests a home-use device that sends a small electrical current to the brain to treat major depression. It may be a good option if you are already on antidepressant medication and have a smartphone.
Boston, MassachusettsAges 22–70 - NCT05549102Recruiting
CBT therapy study for anxiety and brain circuit changes
This trial studies whether a specific form of talk therapy (CBT) changes brain activity in people with moderate anxiety. It may help your care team understand what works best and how brain “circuits” respond to treatment.
LondonAges 18–64 - NCT06860958RecruitingPhase 3
Adding roflumilast to antidepressants for depression
This study tests if adding roflumilast, a medicine that reduces inflammation, can help people with major depression feel better when taken with their current antidepressant. It is for adults with moderate to severe depression.
TantaAges 18–65 - NCT06830044RecruitingPhase 3
Adding an experimental drug for major depression
This trial tests if adding a new medicine called milsaperidone can help people with major depression who haven't gotten enough relief from their current antidepressant. It aims to see if the combination works better than the antidepressant alone.
Phoenix, ArizonaAges 18–65 - NCT06698666RecruitingPhase 3
Can statins help treat depression?
This trial tests if adding a statin (a cholesterol-lowering medicine) to your current depression treatment improves symptoms. It is for adults aged 20 to 45 with mild to moderate depression who are not already taking a statin.
Cairo, Al AbbasiaAges 20–45 - NCT06547489RecruitingPhase 2
Testing zelquistinel for major depression
This study tests whether zelquistinel, an investigational drug, can reduce symptoms of major depressive disorder (a type of clinical depression). It is for people who are currently experiencing a moderate to severe depressive episode and are not taking other antidepressants.
Birmingham, AlabamaAges 18–64 - NCT06450704Recruiting
Exercise for depression: brain and body health
This trial tests if a 12-week exercise program can reduce inflammation and improve brain function in people with depression. It's for adults currently taking antidepressant medication and looking for extra help through physical activity.
Alcalá de Henares, MadridAges 18–65 - NCT06247839RecruitingPhase 3
Psilocybin for depression: changing self-focus
This trial tests whether a single dose of psilocybin can help people with treatment-resistant depression by changing how they focus on themselves. It aims to understand how psilocybin affects brain activity and self-related thinking.
Charlestown, MassachusettsAges 18–55 - NCT06152705Recruiting
fMRI-Guided vs. Standard Brain Stimulation for Depression
This study compares two types of repetitive transcranial magnetic stimulation (rTMS) to treat depression. One type uses a brain scan (fMRI) to guide the treatment, while the other uses a standard approach. It may help people whose depression hasn't improved with medication.
Ottawa, OntarioAges 18 years+ - NCT06132178RecruitingPhase 2
Psilocybin and rTMS for hard-to-treat depression
This study tests whether a combination of psilocybin (a psychedelic substance) and transcranial magnetic stimulation (rTMS, a noninvasive brain stimulation) can help people with treatment-resistant depression. It involves daily visits to the research center for about 2 weeks.
Austin, TexasAges 22–65 - NCT05850689RecruitingPhase 3
Lumateperone add-on for major depression that didn’t improve
This study tests whether adding lumateperone to an antidepressant helps adults with major depressive disorder (MDD) who haven’t improved enough after trying at least two different antidepressants. It may help reduce depressive symptoms more than antidepressants alone.
Huntsville, AlabamaAges 18–65 - NCT04751331RecruitingPhase 1/Phase 2
Study brain response to inflammation in depression
This early-stage study tests how your brain responds to an “inflammatory challenge” in people with major depressive disorder and in healthy volunteers. It may help researchers understand the immune-to-brain link in depression and guide future treatments.
Tulsa, OklahomaAges 18–65 - NCT04509102Enrolling by invitationEarly Phase 1
Test added stimulant medicine with rTMS for depression
This early study tests whether adding a stimulant medicine to repetitive TMS (a non-drug brain stimulation) can improve depression. It is aimed at people whose depression has not improved after at least two antidepressant tries.
Los Angeles, CaliforniaAges 18–65 - NCT04556890Recruiting
Brain stimulation for treatment-resistant depression and chronic pain
This study tests a non-invasive brain stimulation treatment, called transcranial magnetic stimulation (TMS), to see if it can help people who have both major depression that hasn't improved with medication and chronic pain from fibromyalgia or chronic fatigue syndrome. It aims to reduce both depression and pain symptoms.
Los Angeles, CaliforniaAges 18–75
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Common questions
- Are there clinical trials for depression disorders?
- Yes. Clin2 currently lists 669 recruiting depression disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.