Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07228468Recruiting
Home brain stimulation for depression
This trial tests if a gentle electrical current applied to the head at home can help reduce symptoms of major depression. You would use a device for short sessions over several weeks, while continuing your usual care.
CardiffAges 18 years+ - NCT07221929Recruiting
Exercise plus CBT for depression: The CBT+ Trial
This study tests whether adding exercise before standard talk therapy (CBT) helps treat depression more effectively than CBT alone. You will be asked to do moderate exercise and then receive CBT sessions over 8 weeks.
Madison, WisconsinAges 18–65 - NCT07227389Recruiting
Opioid Timing and Breathing Risk After Surgery
This study looks at when opioids are given during surgery and how it affects breathing problems after surgery. It might help understand how to make pain control safer.
Detroit, MichiganAges 18–85 - NCT07226661RecruitingPhase 2
Study of an investigational drug for depression
This trial tests an investigational medication for adults with major depressive disorder who are currently taking an antidepressant but still have symptoms. It aims to see if adding this new drug can improve mood better than a placebo.
Garden Grove, CaliforniaAges 18–70 - NCT07227454RecruitingPhase 3
Esketamine for teens with severe depression and suicidal thoughts
This trial tests if esketamine (a nasal spray) can quickly reduce symptoms of major depression and suicidal thoughts in teenagers who need urgent hospital care.
Birmingham, AlabamaAges 12–17 - NCT06879977Recruiting
Body Awareness Study for People with Depression
This trial studies how people with depression experience body awareness while in the hospital. It may help us understand the connection between body and mind in treating depression.
LinzAges 18–69 - NCT07218055Recruiting
Music for mood in children with depression
This study looks at how listening to or making music might help children with depression. Your child would answer questions or keep a diary about their mood and music experiences.
New York, New YorkAges 7–15 - NCT07216326Recruiting
Depression help for Black and Latinx youth
This trial tests a program to help Black and Latinx teens and young adults with depression. It involves in-person sessions to learn coping skills and support.
Chicago, IllinoisAges 15–20 - NCT07217444Recruiting
Deep TMS for depression in teens
This trial tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) can help teens with moderate to severe depression feel better. It involves wearing a special magnetic coil on the head during several sessions.
Cincinnati, OhioAges 14–18 - NCT07216404RecruitingPhase 2
Psilocybin therapy for depression in lung cancer patients
This trial tests whether a psychedelic-assisted therapy can help treat major depression in people with non-small cell lung cancer. If you have moderate to severe depression and are receiving cancer treatment, you may be able to join.
Columbus, OhioAges 18 years+ - NCT07212465Recruiting
Brain stimulation for depression in older adults
This study tests a new, faster brain stimulation method for depression in adults aged 60-85 who haven't improved with medication. The treatment targets a part of the brain linked to mood and may offer relief for those who have not found other treatments effective.
Toronto, OntarioAges 60–85 - NCT07210255Recruiting
SAINT TMS for postpartum depression
This trial tests a special type of TMS (brain stimulation) called SAINT for severe depression that started around childbirth. It may help new mothers who are still within a year postpartum and have not found relief from other treatments.
Worcester, MassachusettsAges 18–45 - NCT07204314RecruitingPhase 3
Study of vortioxetine for teens with depression in Japan
This trial tests whether vortioxetine helps reduce symptoms of major depression in Japanese teenagers aged 12-17. It compares the study drug to a placebo to see if it is safe and effective.
Nagoya, Aichi-kenAges 12–17 - NCT07211438RecruitingPhase 2
Psilocybin with Monitors for Treatment-Resistant Depression
This study tests whether trained monitors improve the safety and outcomes of psilocybin therapy for people with depression that hasn't responded to other treatments. Participants will receive psilocybin in a supervised setting and will need to temporarily stop other psychiatric medications.
Toronto, OntarioAges 18–70 - NCT06022913Recruiting
Behavioral activation therapy for bipolar depression
This trial tests a therapy called behavioral activation to help people with bipolar depression feel better. The therapy focuses on increasing positive activities and routines to improve mood.
ReykjavikAges 18 years+ - NCT07196501RecruitingPhase 3
Study of a new add-on treatment for depression maintenance
This trial tests a new medication (NBI-1065845) added to your current antidepressant to see if it helps maintain improvement in depression. It is for people whose depression hasn't fully responded to their current oral antidepressant.
Oceanside, CaliforniaAges 18 years+ - NCT03276793Recruiting
Brain connectivity study in people with depression
This study looks at brain “connectivity” (how different brain areas talk to each other) in people with depression. You may be able to join if you are already getting once-daily TMS to a specific brain area at Brigham and Women’s or Massachusetts General, and you can safely complete MRI scans.
Boston, MassachusettsAges 18 years+ - NCT07198438Enrolling by invitation
Deep vs standard brain stimulation for depression
This trial compares two types of brain stimulation (deep vs standard theta burst stimulation) to see which works better for people with depression who haven't gotten enough help from antidepressant medication. It aims to find a more effective treatment option.
Douliu, Yunlin CountyAges 18–70 - NCT07195721Recruiting
How special contact lenses affect mental health
This study looks at whether PROSE or scleral lenses can improve mental health in people with certain eye surface conditions. It may be a good fit if you have a dry eye or related disease and are considering these lenses.
Needham, MassachusettsAges Any age - NCT07197138Recruiting
TMS for depression with long COVID
This trial tests whether accelerated TMS (a brain stimulation treatment) can help people with depression who also have long COVID. It may be an option if your depression hasn't improved enough with medication alone.
Munich, BavariaAges 18–65 - NCT07201480Recruiting
Thinking about death and emotions: a lab study
This study looks at how thinking about death affects feelings of anxiety and sadness. You'll do a short lab task and answer questions.
Cluj-NapocaAges 18–65 - NCT05295888Recruiting
Temporal Interference treatment for moderate-to-severe depression
This study tests temporal interference (TI), a brain stimulation method, to treat depression. You may be a candidate if you have moderate-to-severe major depression and can follow the study schedule and safety screening.
Toronto, OntarioAges 18–65 - NCT07191392Recruiting
Brain stimulation for depression using focused electric fields
This trial tests whether temporal interference stimulation (a noninvasive brain stimulation method) can improve symptoms of depression. It focuses on people who are currently experiencing moderate to severe depression.
Hefei, AnhuiAges 12–60 - NCT07186309Recruiting
At-home test for postpartum depression study
This trial is testing a way to screen for postpartum depression from the comfort of your home. You would take a test during pregnancy to see if it can help find women who may be at risk.
Charlottesville, VirginiaAges 18 years+
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.