Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05295888Recruiting
Temporal Interference treatment for moderate-to-severe depression
This study tests temporal interference (TI), a brain stimulation method, to treat depression. You may be a candidate if you have moderate-to-severe major depression and can follow the study schedule and safety screening.
Toronto, OntarioAges 18–65 - NCT05296356RecruitingPhase 2
Study drug for bipolar depression in people already on mood stabilizers
This trial tests whether OSU6162 can improve depressive symptoms in adults with bipolar depression who are already taking a stable mood-stabilizing medicine. It also checks safety by closely monitoring mood, heart rhythm, and other health factors during the study.
GothenburgAges 18–65 - NCT05356611Recruiting
Study for depression and mild memory thinking problems
This trial tests a program aimed at helping older adults with depression who also have mild thinking and memory difficulties. You may be asked to complete study sessions and tracking, with support for depression symptoms and thinking function.
Las Vegas, NevadaAges 60 years+ - NCT05377177Recruiting
Brain stimulation type test for suicidal thoughts in depression
This study tests whether stimulating the brain on both sides at once versus one side can reduce suicidal thoughts in people with treatment-resistant depression. It also looks at brain “inhibition” signals to help predict who benefits.
San Diego, CaliforniaAges 18–70 - NCT05423275Recruiting
Light treatment to help you stop antidepressants safely
This study tests whether a “light and ion” treatment can help people with major depression (MDD) who are doing well on antidepressants safely reduce or stop them. You must be in remission and be willing to discontinue for reasons like side effects or personal preference.
Vancouver, British ColumbiaAges 19–65 - NCT05426967Recruiting
Brain stimulation for depression after mild traumatic brain injury
This trial studies a noninvasive brain treatment (rTMS) to reduce depression symptoms in people with past mild traumatic brain injury from military service. It may help by changing brain activity, while also requiring stable mental health care and regular follow-up.
Palo Alto, CaliforniaAges 18–55 - NCT05432362Recruiting
Energy sensing brain study in depression and weight groups
This study tests how the brain and body respond to “energy sensing” in people with depression and in people with different body weights. You may be asked to do assessments and follow specific health and diet rules so the researchers can compare groups.
Graz, StyriaAges 18–40 - NCT05435222Recruiting
Male-only therapy program for major depression
This study tests a counseling/psychotherapy program designed specifically for men with major depression. If you qualify, you may be offered this structured therapy and followed to see whether it helps depressive symptoms.
Zurich, Canton of ZurichAges 25–50 - NCT05441969Recruiting
Brain stimulation study for major depression symptoms
This trial studies a way to change how excitable the brain is (through in-person brain stimulation) in people with major depression. It may help understand new treatments or symptom patterns that could be useful for major depression.
LisbonAges 18–65 - NCT05450432RecruitingPhase 4
Ketamine maintenance to help prevent suicidal thoughts
This Phase 4 study tests whether ongoing treatment with ketamine or esketamine can reduce suicidal thoughts in people with major depression who are at high risk. Because the study focuses on long-term maintenance, you’d receive treatment over time while being closely monitored for safety and mental health changes.
Boston, MassachusettsAges 18–70 - NCT05466851Recruiting
Study testing anxiety and depression biology and therapy markers
This study looks at “biopsychosocial markers” (biological, psychological, and social signs) in people with major depression and/or anxiety. It aims to understand what changes with treatment and how those changes connect to symptoms like anxiety and depression.
New York, New YorkAges 18–65 - NCT05523817Recruiting
Brain scan targeting to improve specific depression symptoms
This study uses brain-signal targeting (likely with MRI) to see whether it can improve certain symptoms of depression. You may be able to join if you’re 18–65 and currently have a depressive episode, and if you can safely complete the scan.
Boston, MassachusettsAges 18–65 - NCT05543083Recruiting
Therapy plus exercise for teens at risk of type 2 diabetes
This trial tests whether a combination of coaching (cognitive-behavioral therapy) and exercise can improve mood and help teens who are at higher risk for type 2 diabetes. It may be especially helpful if you’re dealing with depression symptoms and a family history of type 2 diabetes.
Aurora, ColoradoAges 12–17 - NCT05549102Recruiting
CBT therapy study for anxiety and brain circuit changes
This trial studies whether a specific form of talk therapy (CBT) changes brain activity in people with moderate anxiety. It may help your care team understand what works best and how brain “circuits” respond to treatment.
LondonAges 18–64 - NCT05559749Recruiting
Support program for anxiety and depression in people with epilepsy
This study tests a “collaborative care” program to help reduce anxiety and depression symptoms in adults with epilepsy. You would answer questionnaires and work with a care team, and the study is designed to see how well this approach can help over time.
Winston-Salem, North CarolinaAges 18 years+ - NCT05568498RecruitingPhase 2
Probiotic trial for depression in Parkinson’s disease
This Phase 2 study tests whether taking probiotics can improve depression and mood symptoms in people with Parkinson’s disease. It’s meant for those with mild to moderate depression and stable Parkinson’s and mood treatments.
Vancouver, British ColumbiaAges 40–80 - NCT05570344Recruiting
Texting support plus brain stimulation for hard-to-treat depression
This study tests whether adding supportive text messages to brain stimulation (repetitive TMS) helps people with depression that has not improved after at least two antidepressant tries. It may help some people by combining a brain-based treatment with ongoing daily encouragement and support.
Edmonton, AlbertaAges 18 years+ - NCT05570110RecruitingPhase 1/Phase 2
Enoxolone for depression, using body signals to track response
This study tests enoxolone, a medication related to licorice, in people with unipolar (non-bipolar) major depression. It also looks at your body “signals” (biomarkers) to see which ones match with whether treatment helps.
Marburg, HesseAges 18 years+ - NCT05573074Recruiting
Light treatment trial for brain blood flow in depression
This study tests whether shining near-infrared light through the head can change brain blood flow and reduce depression symptoms. If you have major depression, you may be offered a non-drug, device-based approach to see how well it helps.
Boston, MassachusettsAges 18–65 - NCT05577247Recruiting
Study of new thinking skills in hard-to-treat depression
This trial looks at how people with treatment-resistant major depression respond when starting a new depression medicine that affects glutamate signaling. It also involves brain scans and thinking/learning tasks, aiming to understand what helps people improve when standard treatments haven’t worked.
ParisAges 18–70 - NCT05583747Recruiting
Brain stimulation therapy with guidance for treatment-resistant depression
This study tests a type of brain stimulation (guided iTBS) to improve depression when standard antidepressant treatments haven’t helped. It also checks that the treatment is safe for people who can meet the study and scan safety requirements.
Toronto, OntarioAges 18–65 - NCT05585164Recruiting
Therapy program for postpartum depression up to one year
This trial tests a structured talk-therapy program for postpartum depression in the first year after having a baby. It may help by reducing depressive symptoms and improving day-to-day functioning.
New York, New YorkAges Any age - NCT05589337Recruiting
Baduanjin exercise program for depression and anxiety symptoms
This study tests whether practicing Baduanjin (a gentle movement/exercise) can reduce symptoms of depression and anxiety. It may help people who are able to follow instructions and communicate clearly.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05598034Recruiting
Brain stimulation with tDCS for moderate depression
This study tests whether a noninvasive brain stimulation called tDCS can improve depression symptoms. It also uses MRI scans, aiming to understand how brain changes may relate to symptom improvement.
Los Angeles, CaliforniaAges 20–55
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,509 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.