Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07033741Recruiting
EMDR therapy for depression symptoms study
This trial studies whether EMDR therapy helps reduce depressive symptoms and what factors predict improvement. It is open to patients with anxiety, depression, PTSD, or dissociation symptoms.
Turin, TurinAges 18 years+ - NCT07025720Recruiting
Brain stimulation for depression and suicide risk in young people
This study tests a new type of brain stimulation called TMS (transcranial magnetic stimulation) for young people ages 15-25 who are having serious depression and suicidal thoughts. The goal is to see if this treatment can help reduce risk and improve mood.
Sacramento, CaliforniaAges 15–25 - NCT07033780RecruitingPhase 1
Brain stimulation study for depression treatment
This trial tests a new type of brain stimulation called theta-burst stimulation to see if it helps treat depression. It is for people aged 18-50 who are currently experiencing a major depressive episode and are on a stable antidepressant regimen.
Toronto, OntarioAges 18–50 - NCT07022925Recruiting
Wearable device for tracking hot flushes in perimenopause
This study will test if a wearable device can accurately track symptoms like hot flushes and night sweats in women going through perimenopause. If you are between 35 and 55 and experiencing these symptoms, your participation could help improve future symptom monitoring.
London, OntarioAges 35–55 - NCT07022184Recruiting
Lifestyle app for depression with GP support
This trial tests a lifestyle app to help people with depression who are under a GP's care. It looks at whether using the app alongside your usual treatment can improve your mood.
Nijmegen, GelderlandAges 18 years+ - NCT07022171Recruiting
Ear stimulation for depression
This study tests if a gentle electrical device worn on the ear can help improve depression symptoms. It uses a non-invasive method to stimulate the vagus nerve, which may affect mood.
MunichAges 18–65 - NCT07021508Recruiting
Testing a new brain stimulation for bipolar depression
This trial tests a new type of brain stimulation called temporal interference stimulation to see if it can safely and effectively improve symptoms of bipolar depression. It may be an option for people who are not taking medication or who are willing to stop their current medication for a short time.
Hangzhou, ZhejiangAges 18–45 - NCT07022405RecruitingPhase 2
Medication study for depression with brain scans
This study tests whether a targeted medication can improve mood and brain function in adults with major depression. If you qualify, you'll receive a study drug and have fMRI brain scans to see how your brain responds.
Palo Alto, CaliforniaAges 18–65 - NCT07015944Recruiting
Moving on after breast cancer: a depression trial for survivors in Pakistan
This study tests a program called "Moving on After Breast Cancer" for women in Pakistan who have finished breast cancer treatment and now have depression. The goal is to see if this program helps them feel better emotionally.
Karachi, SindhAges 18 years+ - NCT07007234Recruiting
Sedentary behavior and depression study
This study looks at how sitting or being inactive (sedentary behavior) affects depressive symptoms. If you have mild to severe depression, you may be able to join and help find out if moving more can improve your mood.
São Paulo, SOAges 18 years+ - NCT07003763Recruiting
Electroacupuncture for depression in cancer patients
This trial tests whether electroacupuncture can help treat depression caused by cancer or its treatments. It may be a safe option for people who have not tried acupuncture before and are not currently receiving active cancer treatments.
ShanghaiAges 18–75 - NCT07003997RecruitingPhase 2
Targeting inflammation for depression treatment
This trial tests whether a medication that targets inflammation in the body can help relieve depression symptoms. You will have blood tests and an MRI to see how your brain and immune system respond.
Atlanta, GeorgiaAges 25–55 - NCT07002684Recruiting
Esketamine study for depression
This trial tests how treatment with esketamine affects metabolism in people with depression. It may help if you have not responded to at least two standard antidepressants.
ZagrebAges 18–70 - NCT06997549Recruiting
Review of mental health treatment outcomes
This study looks back at information from a large database of people who received mental health treatments. It aims to understand how well treatments worked and what factors influenced outcomes.
Malvern, PennsylvaniaAges 5–100 - NCT06995807Recruiting
EL-SHIN therapy for depression and stress
This trial tests a new therapy called EL-SHIN for people with moderate depression, anxiety, and stress. It may help if you are a non-Muslim who believes in creationism.
Kuala LumpurAges 18 years+ - NCT06996925Enrolling by invitation
Depression, illness beliefs, and erectile function
This study looks at how your feelings about your health and your mood may affect erectile dysfunction. It could help doctors understand the link between depression and erectile problems.
IstanbulAges 18 years+ - NCT07002554Enrolling by invitationPhase 2
Bright light therapy for older adults with depression in the hospital
This study tests whether bright light therapy helps reduce depression in adults aged 60 and older who are hospitalized for depression. If you are currently staying on the Senior Care Unit at MUSC and have a depression diagnosis, this treatment might be an option for you.
Charleston, South CarolinaAges 60 years+ - NCT06982820Recruiting
Brain training therapy for depression with loss of interest
This trial tests a new type of brain training (self-neuromodulation) to help people with major depression who also have a significant loss of interest or pleasure (anhedonia). If you qualify, you may get a non-invasive treatment that uses real-time brain feedback to improve symptoms.
Providence, Rhode IslandAges 22–75 - NCT06983405Recruiting
Physical therapy for depression and quality of life pilot
This study is testing whether adding physical therapy to your usual depression care can improve your quality of life while you are in the hospital. If you are an adult admitted to the psychiatry unit with major depression, you may be able to join.
Zaragoza, AragonAges 18 years+ - NCT06991166Recruiting
A therapy study for new mothers with depression whose baby is in the NICU
This study tests a new talk therapy program to help new mothers with depression whose babies are in the neonatal intensive care unit (NICU). You may join if you gave birth in the last year and have signs of depression, like a diagnosis or certain feelings.
Hackensack, New JerseyAges 18 years+ - NCT06976697Recruiting
Home-based tDCS for major depression
This trial tests a home-use device that sends a small electrical current to the brain to treat major depression. It may be a good option if you are already on antidepressant medication and have a smartphone.
Boston, MassachusettsAges 22–70 - NCT06728774Recruiting
Cognitive rehab for veterans with depression and memory problems
This trial tests a cognitive rehabilitation program for veterans who have depression (MDD) and are experiencing trouble with memory, attention, or thinking. The goal is to see if the program can improve these cognitive issues.
Portland, OregonAges 18 years+ - NCT06976840Recruiting
Rapid antidepressant effects of new brain stimulation methods
This trial tests whether two types of non-invasive brain stimulation can quickly improve depression symptoms. It may be an option for adults with major depression who are not currently taking psychiatric medication.
Pittsburgh, PennsylvaniaAges 18–55 - NCT06973759Recruiting
Bright light therapy for teens with depression who are night owls
This study tests whether bright light therapy in the morning can help Chinese teenagers with depression who tend to stay up late and feel more energetic in the evening. It aims to see if adjusting your body clock with light can improve mood.
Hong Kong, Hong KongAges 12–19
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.