Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06963021RecruitingPhase 3
Study of NBI-1065845 for depression that hasn't fully responded to treatment
This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.
Chino, CaliforniaAges 18 years+ - NCT06966401RecruitingPhase 3
Long-term safety study of a new depression treatment
This study tests a new oral medication (NBI-1065845) added to your current antidepressant to see if it's safe and tolerable over a long period for people with depression that hasn't fully responded to treatment.
Huntsville, AlabamaAges 18 years+ - NCT06972368Recruiting
Home brain stimulation for depression in borderline personality disorder
This trial tests whether a gentle brain stimulation device (tDCS) used at home can help with depression in people with borderline personality disorder. If you have BPD and current depression, you may be able to participate from home using your smartphone.
Montreal, QuebecAges 18–65 - NCT06963463Recruiting
Sleep & light therapy for teens with depression
This study tests a program that combines sleep and light therapy to help teens with depression and sleep problems feel better. It focuses on improving your sleep schedule and adding bright light exposure to boost mood.
Philadelphia, PennsylvaniaAges 12–18 - NCT06951542Enrolling by invitation
Reducing HIV and mental health stigma in Malawi
This study tests a program to reduce stigma for people living with HIV who also have symptoms of depression. It aims to improve mental health and HIV outcomes.
MulanjeAges 18 years+ - NCT06943573RecruitingPhase 2
Psilocybin therapy for bipolar ii depression
This study tests whether a psychedelic drug called psilocybin (the active ingredient in 'magic' mushrooms), combined with therapy, can help relieve depression in people with bipolar II disorder who haven't gotten better with other treatments. You'll receive the drug in a supervised setting and attend follow-up visits to see how it affects your mood.
Vancouver, British ColumbiaAges 19–65 - NCT06928428Enrolling by invitation
Online talk therapy for depression or anxiety
This study tests if a type of talk therapy called metacognitive therapy, delivered partly online, helps adults with depression or generalized anxiety. It aims to see if this blended approach works well in primary care.
Stockholm, Stockholm CountyAges 18 years+ - NCT06923995Recruiting
AI-based depression and anxiety assessment study
This study tests an AI tool that analyzes video and audio recordings to measure depression and anxiety. It is for people starting a new treatment for depression or anxiety and aims to see if the AI can accurately track their progress.
Houston, TexasAges 18–65 - NCT06786936Recruiting
Study of IL-17 in depression with psoriasis
This study explores whether a protein called IL-17 might link skin/joint inflammation with depressive symptoms. If you have psoriasis or psoriatic arthritis and are starting a specific biologic (secukinumab, bimekizumab, or ixekizumab), this could help understand how treatment affects your mood.
Glasgow, ScotlandAges 18–74 - NCT04057378RecruitingPhase 4
Testing the best electrical settings for ECT for depression
This trial studies which electrical “pulse settings” work best during electroconvulsive therapy (ECT) for people with depression. It may help doctors personalize ECT so the treatment is safer and works as well as possible for you.
ÖrebroAges 18 years+ - NCT03522545RecruitingPhase 1
Stem cell add-on for hard-to-treat bipolar depression
This Phase 1 study tests whether adding allogeneic (donor) stem cells to standard care is safe and may help adults with bipolar depression that has not improved with usual treatments. It mainly targets people with more severe symptoms and certain blood inflammation levels.
Houston, TexasAges 18–65 - NCT06917339Recruiting
A study looking at past treatment records
This trial looks back at medical records in the TrakStar database to understand how treatments were given. It does not test a new drug, but helps researchers learn from past treatment experiences.
Malvern, PennsylvaniaAges 5–120 - NCT06913309Recruiting
Home bright light therapy for teen depression
This study tests whether a bright light therapy device you can use at home can help improve depression symptoms in teenagers aged 13-17. It compares the results of using the light with a non-active placebo device.
Beijing, Beijing MunicipalityAges 13–17 - NCT06911112RecruitingPhase 3
A new pill for depression when current treatment isn't working well enough
This trial tests an investigational medication (NBI-1065845) added to your current antidepressant to see if it can improve depressive symptoms. It is for people with moderate to severe depression who have not fully responded to their current antidepressant.
Huntsville, AlabamaAges 18 years+ - NCT06909669Recruiting
Brief therapy for anxiety, depression, or physical symptoms
This study tests short-term psychological treatments to help people with mild or moderate emotional symptoms like anxiety, depression, or physical complaints (such as pain or fatigue) that may be linked to stress. The goal is to see if these brief therapies can improve how you feel.
Córdoba, CórdobaAges 18 years+ - NCT06910267Recruiting
Depression treatment study for older adults in APS
This study tests if a proven depression treatment can help older adults who are involved with Adult Protective Services due to neglect or self-neglect. If you are feeling depressed and have an open APS case, you may qualify.
Houston, TexasAges 65 years+ - NCT06901687RecruitingPhase 2
Home brain stimulation for depression in MS
This study tests whether a special, gentle brain stimulation device you can use at home (called tDCS) can help improve depression symptoms in people with multiple sclerosis. You will be supervised over video during the sessions to make sure everything goes smoothly.
New York, New YorkAges 18–65 - NCT06906003Recruiting
Vision rehab and depression in age-related macular degeneration
This trial tests whether visual rehabilitation can help improve both vision and mood in people with advanced dry age-related macular degeneration. It aims to understand the link between vision loss and depression.
Rome, ItalyAges 55 years+ - NCT06906939RecruitingEarly Phase 1
Brain stimulation and tai chi for knee arthritis and depression
This pilot study tests if combining brain stimulation (rTMS) with Tai Chi can help knee arthritis pain and improve depression. It compares these two treatments to see which works better for people with both pain and low mood.
Los Angeles, CaliforniaAges 50–95 - NCT06892847Recruiting
Brain stimulation for anxiety and depression in youth
This study tests if a non-invasive brain stimulation technique called TMS can help reduce symptoms of anxiety or depression in children and teens. It involves sessions where a magnetic field is used to gently stimulate parts of the brain, and is designed for young people aged 6 to 18 who have been diagnosed with these conditions.
Calgary, AlbertaAges 6–18 - NCT06895863Recruiting
Personalized magnetic brain therapy for hard to treat depression
This study tests a new way to use magnetic brain stimulation tailored to each patient to treat depression that hasn't improved with at least two different medications. It may help people who are still struggling with moderate to severe depression.
Glostrup MunicipalityAges 18–95 - NCT06898788RecruitingEarly Phase 1
Probiotics for depression in teens and young adults
This study tests whether a probiotic supplement can help improve depression in young people who are already taking an SSRI antidepressant. If you join, you will take a probiotic or placebo for several weeks and have your mood and brain activity checked.
San Francisco, CaliforniaAges 15–24 - NCT06898606RecruitingPhase 1/Phase 2
Psilocybin mushrooms with or without Prozac for stubborn depression
This study tests whether a dose of psilocybin (the active ingredient in magic mushrooms) can help treat depression that hasn't improved with standard antidepressants. Some participants will also take the antidepressant fluoxetine (Prozac) to see if it changes the effects.
Foz do Iguaçu, ParanáAges 25–65 - NCT05549102Recruiting
CBT therapy study for anxiety and brain circuit changes
This trial studies whether a specific form of talk therapy (CBT) changes brain activity in people with moderate anxiety. It may help your care team understand what works best and how brain “circuits” respond to treatment.
LondonAges 18–64
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.