Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07002554Enrolling by invitationPhase 2
Bright light therapy for older adults with depression in the hospital
This study tests whether bright light therapy helps reduce depression in adults aged 60 and older who are hospitalized for depression. If you are currently staying on the Senior Care Unit at MUSC and have a depression diagnosis, this treatment might be an option for you.
Charleston, South CarolinaAges 60 years+ - NCT06996925Enrolling by invitation
Depression, illness beliefs, and erectile function
This study looks at how your feelings about your health and your mood may affect erectile dysfunction. It could help doctors understand the link between depression and erectile problems.
IstanbulAges 18 years+ - NCT06928428Enrolling by invitation
Online talk therapy for depression or anxiety
This study tests if a type of talk therapy called metacognitive therapy, delivered partly online, helps adults with depression or generalized anxiety. It aims to see if this blended approach works well in primary care.
Stockholm, Stockholm CountyAges 18 years+ - NCT06821646Enrolling by invitation
Brain responses in depression and autism with TMS and EEG
This study uses brain stimulation (TMS) and brain wave recording (EEG) to understand how the brain works in people with autism, depression, or both. It may help find better ways to treat these conditions.
TaipeiAges 20–50 - NCT06792175Enrolling by invitation
Using speech to detect mental health conditions
This study uses a computer program to listen to your speech and see if it can help detect mental health or neurodevelopmental conditions. It may help find new ways to diagnose conditions like ADHD, anxiety, depression, and others earlier.
Brookline, MassachusettsAges 13–60 - NCT06770244Enrolling by invitation
Positive psychology for postpartum depression in primary care
This trial tests a program based on positive psychology to help prevent or reduce postpartum depression. It is offered within the primary healthcare system and focuses on supporting mothers early in pregnancy.
Wuhan, HubeiAges 18 years+ - NCT06660888Enrolling by invitation
Study of fatigue, depression, and anxiety in people with low thyroid
This study looks at how common fatigue, depression, and anxiety are in people with hypothyroidism (underactive thyroid). It aims to understand if these symptoms are linked to thyroid hormone levels.
Asyut, AssuitAges 18–60 - NCT06628830Enrolling by invitation
App for depression and anxiety in college students
This trial tests if a mobile phone app can help college students with mild to moderate depression and anxiety. You may be eligible if you are a student with moderate symptoms and not currently in treatment.
Santiago, Santiago MetropolitanAges 18–29 - NCT06512324Enrolling by invitation
TMS with remote viewing for depression and anxiety
This trial tests whether adding 'remote viewing' (a technique where a person tries to perceive a distant target) to standard TMS brain stimulation can improve depression and anxiety symptoms. It is for people already getting TMS and who can attend weekly visits.
Encinitas, CaliforniaAges 12 years+ - NCT06389175Enrolling by invitation
Non-invasive ear stimulation for depression
This study uses a gentle, non-invasive device that stimulates the vagus nerve in your ear to see if it can improve how your stomach and brain communicate, which may help with depression symptoms.
BonnAges 18–55 - NCT06234371Enrolling by invitation
Financial rewards for veterans finishing therapy
This trial tests whether offering money helps veterans stick with their counseling sessions. If you're a veteran in individual therapy, you may be able to earn financial incentives for completing your treatment.
Dallas, TexasAges 18 years+ - NCT06221280Enrolling by invitation
Nerve blocks for pain after cesarean and depression
This study tests whether a nerve block (extra numbing medicine) given during a cesarean section can help with pain after delivery and may reduce the risk of postpartum depression. The trial compares the nerve block to standard care.
Kahramanmaraş, KahramanmaraşAges 18 years+ - NCT06145555Enrolling by invitation
Sleep stabilization therapy for hospitalized depression
This study tests a quick, non-drug sleep therapy for people in the hospital for depression. It aims to help stabilize your sleep to improve your mood and recovery.
StockholmAges 18 years+ - NCT06044324Enrolling by invitation
Imaging brain activity in TMS for depression
This trial uses PET scans to see how transcranial magnetic stimulation (TMS) affects the brain in people whose depression hasn't improved with at least two different antidepressants. It aims to find markers that could predict who might benefit from TMS.
Hangzhou, ZhejiangAges 18–45 - NCT05989412Enrolling by invitation
Mobile screening for depression in Rotterdam Zuid
This study uses a mobile app to screen for signs of major depression in adults from diverse backgrounds in Rotterdam Zuid. The goal is to find people who might have undiagnosed depression and guide them to care.
RotterdamAges 18 years+ - NCT05487911Enrolling by invitation
Brain stimulation (rTMS) for depression symptoms
This trial tests whether a non-surgical brain stimulation technique (rTMS) can reduce depression symptoms in adults with major depression. You would likely have several study visits that include brain scans (MRI) and treatment sessions to see if symptoms improve.
Houston, TexasAges 18–64 - NCT05183503Enrolling by invitation
Study of pain, stress, anxiety, and depression in jaw disorder
This study looks at how chronic jaw pain from temporomandibular disorder (TMD) relates to stress, anxiety, and depression in adults. Your results may help researchers better understand what affects symptoms and how people respond to care.
WroclawAges 18–80 - NCT04959227Enrolling by invitation
Study of mood and movement in whirling dervishes
This study looks at how anxiety and depression, along with physical activity, may relate to regular whirling dervish (Sema) practice. You might be able to join if you’re an adult who has practiced Sema regularly for a long time and don’t have certain health conditions.
BalıkesirAges 18–60 - NCT04509102Enrolling by invitationEarly Phase 1
Test added stimulant medicine with rTMS for depression
This early study tests whether adding a stimulant medicine to repetitive TMS (a non-drug brain stimulation) can improve depression. It is aimed at people whose depression has not improved after at least two antidepressant tries.
Los Angeles, CaliforniaAges 18–65 - NCT03736538Enrolling by invitationPhase 1
Nitrous oxide for suicidal thoughts in depression
This Phase 1 study tests whether breathing nitrous oxide can safely reduce suicidal thoughts in adults with major depression. It may help people whose depression is causing moderate to severe suicidal thinking, by studying a fast-acting treatment approach.
St Louis, MissouriAges 18–65 - NCT07149428Enrolling by invitation
Deep study of smell loss causes using brain scans
This study uses brain imaging and electrical recordings to understand the brain's role in smell loss from any cause—like COVID, sinus problems, or chemotherapy. You may be eligible if you have any degree of smell loss lasting under a year.
Bethesda, MarylandAges 18–99 - NCT07226128Recruiting
Can therapy help HIV patients with depression and insulin resistance?
This study tests if cognitive behavioral therapy (a type of talk therapy) can improve how your body handles sugar (insulin resistance) for people living with HIV who also have depression. You may join if you have HIV, are on stable HIV meds, feel depressed, and do not have diabetes.
Indianapolis, IndianaAges 18 years+ - NCT07768670Recruiting
Smartphone exercise program for older adults
This study tests a personalized exercise program delivered through a smartphone app to help older adults become more active. You would use the app to get exercise recommendations and track your progress.
Knoxville, TennesseeAges 65 years+ - NCT06898879Recruiting
Working together to improve mental health care for veterans
This study is for veterans getting mental health support through VA programs. It tests a way to improve teamwork between veterans and their care teams to make the care better.
San Diego, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,509 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.