Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06362538Recruiting
Heart health prevention program
This trial tests a program to help prevent heart problems in people who have not had a heart attack or stroke. It is for adults aged 30 and older.
Cotignola, RavennaAges 18–30 - NCT07762066Recruiting
Peer support to reduce loneliness and depression in older gay and bisexual men with HIV
This study tests whether meeting with a trained peer supporter can help reduce loneliness and depression in older gay and bisexual men living with HIV. You will be paired with someone who has similar experiences, and together you'll work on building connections and improving your mood.
Boston, MassachusettsAges 50 years+ - NCT07765355Recruiting
Virtual nature for anxiety in hospitalized older adults
This trial tests whether watching virtual nature scenes or guided imagery can help reduce anxiety and improve well-being in older adults while they are in the hospital. It may offer a calming, drug-free way to support your mental health during a hospital stay.
BudapestAges 65 years+ - NCT07745920Recruiting
An online program for depression in people with adpkd
This study tests an internet-based program to help manage depression symptoms in people with ADPKD. The program may be a convenient way to get support for your mood without traveling to a clinic.
Rochester, MinnesotaAges 18–70 - NCT07741981Recruiting
Biological markers for treatment-resistant psychiatric disorders
This study looks for biological markers in the blood or spinal fluid that might predict how well a new psychiatric treatment will work. If you have a psychiatric condition that hasn't improved with previous treatments, this research could help find better ways to match treatments to individuals in the future.
ParisAges 18 years+ - NCT07717385Recruiting
90-day trial of a probiotic for stress and sleep
This study tests whether a daily probiotic capsule called Neuralli Mood can help adults who feel stressed, have trouble sleeping, or experience low mood. It lasts 90 days and involves taking two capsules each day and filling out online surveys.
New York, New YorkAges 18 years+ - NCT07717723Recruiting
Support for caregivers of heart disease patients
This study tests a program to help caregivers of people with heart disease manage stress and challenges. It aims to support your mental health while caring for a loved one.
Sacramento, CaliforniaAges 18 years+ - NCT07719517Recruiting
Morning activities to boost mood after stroke
This study tests if doing simple, guided activities in the morning can help improve your mood after a stroke. If you often feel down and have trouble getting going in the morning, this program might offer a way to feel better.
Hong KongAges 18 years+ - NCT07722949Recruiting
A nurse-led program for caregivers of children with autism
This study tests a culturally adapted program where nurses help caregivers build skills to support a child with autism. It aims to reduce stress and improve well-being for both the caregiver and the child.
Faisalābad, Punjab ProvinceAges 18 years+ - NCT07717541Recruiting
Virtual poetry workshops for anxiety and stomach issues
This study tests if joining a facilitated online poetry workshop can help reduce anxiety and improve well-being for people with stomach discomfort. You would attend virtual group sessions and share poems you create.
Columbus, OhioAges 18 years+ - NCT04621877Recruiting
Lay-led therapy for depression and anxiety at senior centers
This trial tests a structured, coach-led program called behavioral activation delivered in senior centers. It aims to improve symptoms of depression and generalized anxiety by teaching practical, step-by-step activity planning.
Brandon, FloridaAges 60 years+ - NCT07707453Recruiting
Studying work and well-being of internal medicine residents
This study follows resident doctors in general internal medicine over time to understand their professional and personal experiences, including stress and career growth. It aims to improve support for doctors in training.
BernAges Any age - NCT07706816Recruiting
Remote stress recovery program for young heart attack survivors
This study tests a remote program to help people under 55 recover from the stress of a heart attack. It aims to see if the program is practical and helpful for reducing distress after a heart attack.
UppsalaAges 18–55 - NCT07707037Recruiting
Helping parents cope after a child's cardiac arrest
This study tests if providing clearer information to parents after their child's cardiac arrest can reduce fear and anxiety. It is for parents of children under 17.5 years old who are expected to leave the hospital soon.
Philadelphia, PennsylvaniaAges birth–17 years - NCT07713849Recruiting
Transition care for recent psychosis
This study tests a program to help people recently diagnosed with psychosis (within the last two years) transition from hospital to community care. If you have a psychotic disorder and a caregiver involved in your discharge planning, this could help you.
Chicago, IllinoisAges 18–40 - NCT07702448Recruiting
Jaw surgery and its effect on mood and looks
This study looks at how jaw surgery affects your mood and how you feel about your appearance. You will answer questions one week before surgery and again 6 months after, and you need to use social media as part of the research.
Kirikkale, KırıkkaleAges 18–40 - NCT07698379Recruiting
Preventing burnout in healthcare workers with compassion therapy
This trial tests whether an online compassion-based therapy program can prevent burnout in Spanish doctors and nurses. It aims to help you manage stress and emotional exhaustion from work.
Zaragoza, SpainAges 18–75 - NCT07704138Recruiting
Testing process-based therapy for depression and anxiety
This trial tests a type of talking therapy called process-based therapy to see how well it works in everyday care. It focuses on treating depression or anxiety and helps therapists learn how to make better treatment decisions.
Frankfurt am Main, HesseAges 18–65 - NCT07705776Recruiting
SanaMente: A peer-led program for Latino/a well-being
This trial tests a peer-led program called SanaMente to help rural Latino/a adults manage stress, improve mood, and prevent or manage chronic health conditions like diabetes or heart disease. You'll join either group or one-on-one sessions focused on emotional and physical health.
Carbondale, ColoradoAges 18 years+ - NCT06650436Recruiting
Stroke, Delirium, and Long-Term Thinking Changes
This study looks at the link between stroke, delirium (sudden confusion), and long-term thinking problems. It tests whether EEG and MRI scans can help predict who may have trouble thinking clearly after a first stroke.
BrusselsAges 18 years+ - NCT07692269Recruiting
Mindfulness for emotional distress study
This study tests whether mindfulness can help reduce emotional distress. You will practice mindfulness and have your brain activity measured with EEG, a safe and painless way to record brainwaves.
Beijing, Beijing MunicipalityAges 18–50 - NCT07682753Recruiting
Mental health support for autistic college students
This study tests a mental health program for autistic college students who feel stressed, anxious, or down. You would join weekly sessions for 8 weeks to see if the program helps improve your well-being.
Edinburg, TexasAges 18–30 - NCT07685860Recruiting
PET scan study for depression with MAO-A
This study uses a special PET scan to look at MAO-A, a brain chemical linked to depression. It may help doctors better understand and diagnose depression.
Hefei, AnhuiAges 18–90 - NCT07682935Recruiting
Fishing therapy for schizophrenia: mood and quality of life
This study tests if fishing, as a supportive therapy, can help people with schizophrenia improve mood, reduce anxiety, and boost quality of life. It looks at changes in blood markers and well-being.
Elâzığ, CenterAges 18–60
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.