Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06526078Recruiting
Combining brain training with ketamine for depression
This study tests if adding computer-based cognitive training to ketamine treatment can improve mood in people with depression that hasn't responded to other treatments. It aims to see if the combination works better than ketamine alone.
Oakland, CaliforniaAges 18–80 - NCT06093906Recruiting
Positive processes and transition to health (PATH) study
This study tests a new therapy that may help people recover after a stressful life event. Over about 6 weeks, you'll work with a coach to retrain your brain's patterns and feel more in control again, as well as reconnect with positive activities.
Newark, DelawareAges 18–65 - NCT07606248Recruiting
Virtual forest mindfulness for pregnant women's mental health
This study tests whether using virtual reality to explore a calming digital forest helps reduce stress and improve mood during pregnancy. You'd use a VR headset a few times to practice mindfulness (focused breathing and relaxation) and complete short surveys about how you're feeling.
HsinchuAges 18 years+ - NCT05426057Recruiting
Mental health support for Hispanic teens with caregiver involvement
This study looks at improving mental health in primary care by involving both a teen and an adult caregiver. It may help families who are struggling with communication, depression or anxiety symptoms, or past suicidal thoughts or behaviors.
Miami, FloridaAges 12–16 - NCT06221020Recruiting
Enhanced recovery after pituitary tumor surgery
This study tests a standard care plan to help patients recover faster after surgery to remove a pituitary tumor. It may reduce hospital stay and improve recovery.
Kaohsiung CityAges 20–75 - NCT05613972Recruiting
Combined therapy for adults with suicidal thoughts and childhood trauma
This study tests a new combination of talk therapies for adults who have both suicidal thoughts and a history of childhood trauma. The goal is to see if this combined approach reduces suicide risk better than usual care.
Toronto, OntarioAges 18 years+ - NCT07765355Recruiting
Virtual nature for anxiety in hospitalized older adults
This trial tests whether watching virtual nature scenes or guided imagery can help reduce anxiety and improve well-being in older adults while they are in the hospital. It may offer a calming, drug-free way to support your mental health during a hospital stay.
BudapestAges 65 years+ - NCT06899165RecruitingPhase 2
Psilocybin therapy for inherited trauma
This trial tests whether psilocybin (a psychedelic substance) combined with therapy can help adult children of genocide survivors who experience symptoms of trauma, depression, or anxiety. The goal is to see if this approach can reduce the emotional impact of intergenerational trauma.
New York, New YorkAges 18 years+ - NCT07762066Recruiting
Peer support to reduce loneliness and depression in older gay and bisexual men with HIV
This study tests whether meeting with a trained peer supporter can help reduce loneliness and depression in older gay and bisexual men living with HIV. You will be paired with someone who has similar experiences, and together you'll work on building connections and improving your mood.
Boston, MassachusettsAges 50 years+ - NCT05669703Recruiting
Tracking mood and activity patterns in bipolar disorder families
This study watches how a person’s mood and movement change over time, and how those patterns relate to bipolar disorder. It may help researchers better understand the condition in families and potentially improve future care.
Bethesda, MarylandAges 8–70 - NCT07359157Recruiting
Support program for WRCH patients with legal history
This study offers a group program at Worcester Recovery Center and Hospital (WRCH) aimed at helping people who have been involved with the legal system. It is designed for current patients at WRCH who are at least 18 years old and comfortable speaking English.
Worcester, MassachusettsAges 18 years+ - NCT06529029RecruitingPhase 2/Phase 3
Comparing new low-pulse ECT to standard ECT for depression
This trial tests a new type of seizure therapy (low amplitude pulse seizure therapy) against the standard ultra-brief right unilateral ECT for people with severe depression, including those with suicidal thoughts. The goal is to see which treatment works better.
Grand Rapids, MichiganAges 18–90 - NCT06687291Recruiting
Thinking and memory after stomach or esophagus cancer surgery
This study looks at how surgery and chemotherapy for stomach or esophageal cancer may affect your thinking, memory, and other cognitive functions. Researchers want to understand these changes to better support patients.
HuddingeAges 18 years+ - NCT06262178Recruiting
Parenting support for mothers in military families
This study tests a parenting program designed to help mothers in military families cope with past trauma and improve their relationship with their child. The program aims to reduce PTSD and depression symptoms while increasing parenting confidence.
El Paso, TexasAges 18 years+ - NCT06929208Recruiting
Music and heart rate during procedures
This trial studies how listening to music affects your heart rate and stress response during a procedure like surgery or a pain treatment. It may help you relax and feel more comfortable.
SingaporeAges 21–90 - NCT07745920Recruiting
An online program for depression in people with adpkd
This study tests an internet-based program to help manage depression symptoms in people with ADPKD. The program may be a convenient way to get support for your mood without traveling to a clinic.
Rochester, MinnesotaAges 18–70 - NCT04106713Recruiting
Understanding change across different psychotherapies for anxiety and depression
This study looks at how people change during different types of psychotherapy for anxiety and depression. It aims to understand which treatments work best for different people.
Singapore, SingaporeAges 18–99 - NCT07222306Enrolling by invitation
Cannabis, brain inflammation, and suicidal thoughts brain imaging study
This study uses brain scans to see how cannabis affects inflammation and suicidal thoughts. You may join if you're already in a related study and can safely undergo MRI and PET scans.
Detroit, MichiganAges 19–69 - NCT06902636Recruiting
Trauma care program for older adults living alone
This trial tests a special care program for older adults who live alone and have limb injuries. It aims to help them recover safely at home using smartphone support for three months.
Kaohsiung City, KaohsiungAges 65 years+ - NCT06907654Recruiting
Couples' affect and relationships study
This study looks at how couples' moods and relationships interact over time. You and your partner will use a smartphone app and respond to daily text surveys for 3 weeks.
Madison, WisconsinAges 18 years+ - NCT07032480Recruiting
Sleep, Neck Pain, and Depression Study
This study looks at how sleep problems, neck pain, and depression might be connected in healthy young adults. It aims to help understand these common issues better.
Istanbul, ÜsküdarAges 18–28 - NCT06726304Enrolling by invitation
Increasing physical contact for mothers with anxiety or depression
This study tests whether using a baby carrier more often helps mothers with anxiety or depression feel more connected to their babies. It is for mothers who had a healthy baby and were diagnosed with anxiety or depression during pregnancy.
Montreal, QuebecAges 18 years+ - NCT06584253Recruiting
Digital addiction study for university students
This study looks at how university students use smartphones and whether they develop digital addiction. It's a simple survey-based study to understand patterns and risks.
Iğdır, IğdırAges 18 years+ - NCT06464445Recruiting
Optimizing brain stimulation for mood health
This study tests a type of brain stimulation (iTBS) to see if it can improve mood in healthy young adults. Researchers want to understand how the treatment works in the brain before testing it on people with depression.
Sherbrooke, QuebecAges 18–35
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,509 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.