Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06292637Recruiting
Faith-focused counseling for depression in African Americans
This study tests whether adding a faith-based support group to a counseling program helps African American adults with depression feel better. You would join group sessions that combine talking through your thoughts (cognitive behavioral therapy) with fellowship and spiritual support.
Madison, WisconsinAges 18 years+ - NCT06273137Recruiting
Positive affect treatment for teens with early adversity
This trial tests a treatment designed to improve positive emotions in adolescents who have experienced stressful early life events. It may help your teen build resilience and emotional wellbeing.
Irvine, CaliforniaAges 12–16 - NCT06248710RecruitingPhase 2/Phase 3
Dog presence and oxytocin spray for trust in therapy
This study explores whether being with a friendly dog and getting a nasal spray of oxytocin (a natural hormone) can help you feel more trust toward a therapist. It's looking for healthy adults who are comfortable around dogs.
Basel, Canton of Basel-CityAges 18 years+ - NCT06257095Recruiting
Phone Support Program for Older Adults Leaving APS
This study is testing a phone-based support program for older adults who have been helped by Adult Protective Services and are now moving on. College students in health fields will provide friendly, weekly check-in calls to help with social and emotional needs.
Houston, TexasAges 65 years+ - NCT06057337Recruiting
Families with pride for Hispanic LGBTQ+ teens
This study helps Hispanic LGBTQ+ teens and their families build stronger bonds and pride. It includes family activities and conversations to support your identity and well-being.
Coral Gables, FloridaAges 13–19 - NCT06034821Enrolling by invitationPhase 4
ECT vs. ketamine for suicidal depression in adults
This trial compares two treatments—ECT (electroconvulsive therapy, which uses electrical stimulation) and ketamine (a medicine given as a shot)—to see which works better for quickly reducing suicidal depression. It is for adults who are in a severe depressive episode with active suicidal thoughts.
San Francisco, CaliforniaAges 18–90 - NCT06085937RecruitingPhase 1
Ketamine for suicidal patients in the ER
This trial tests if a single dose of ketamine can quickly reduce suicidal thoughts in people who come to the emergency department. If you are having active suicidal thoughts and need inpatient care, you may be able to join.
Kansas City, KansasAges 18–65 - NCT05748730Recruiting
Care team support program for teens at risk of depression
This study tests an “integrated care” program that supports teens who are dealing with depression symptoms or recent suicidal thoughts. It also involves a parent or caregiver to help improve support at home and connect teens to the right help.
Gibbsboro, New JerseyAges 12–18 - NCT05655390Recruiting
Study after a suicide attempt testing a new treatment link
This study looks at how well an approach helps people after a suicide attempt, and how certain measurements in the body and thinking relate to outcomes. You may be able to join if you’re an adult and can safely complete the study assessments.
Barcelona, BarcelonaAges 18 years+ - NCT05652153Recruiting
Brain-signal study for teens with depression and suicide thoughts
This study looks at how certain brain “inhibitory” signals work in teenagers and young adults who have depression and either suicide thoughts or past suicide behavior. The goal is to better understand suicide risk and what might help reduce it, using brain and brainwave testing.
Minneapolis, MinnesotaAges 13–21 - NCT05280028Recruiting
Hormone treatment for overactive bladder and mood symptoms
This trial studies whether hormone treatment can improve overactive bladder symptoms, sexual well-being, mood (depressive symptoms), and body “autonomic” function (automatic body functions like heart rate and sweating) in post-menopausal women. It may help by targeting menopausal changes that can affect these symptoms.
Banqiao District, New TaipeiAges 20 years+ - NCT06378450Recruiting
Mindfulness meditation: finding the right dose
This study tests how different amounts of mindfulness meditation affect people's mental health. It is for Australian adults who are new to meditation and do not have severe mental or physical health conditions.
Carlton, VictoriaAges 18–65 - NCT05553197Recruiting
Track mood during therapy using smartphone check-ins
This study looks at how mood changes between therapy sessions by having you answer short mood questions on your smartphone. It may help the researchers understand what support works best for people with mild-to-moderate depression.
Zurich, Canton of ZurichAges 18 years+ - NCT04857775Recruiting
Test a parent-training app for infants and toddlers
This study tests a web and mobile program that supports parents with training for their child’s early development. It uses parent sessions over about 10–12 weeks and includes a small blood sample to help researchers measure effects.
Calgary, AlbertaAges Any age - NCT05183230Recruiting
Mobile program to help prevent suicide after hospital stay
This trial tests a phone-based (mobile) support program for middle-aged and older adults after a recent hospital stay for suicidal thoughts or an attempt. The goal is to reduce the chance of another suicidal crisis by providing structured support after discharge.
New York, New YorkAges 50–90 - NCT04621877Recruiting
Lay-led therapy for depression and anxiety at senior centers
This trial tests a structured, coach-led program called behavioral activation delivered in senior centers. It aims to improve symptoms of depression and generalized anxiety by teaching practical, step-by-step activity planning.
Brandon, FloridaAges 60 years+ - NCT05377463Recruiting
Behavior coaching to help keep HIV virus levels controlled
This study tests a counseling program (bio-behavioral intervention) designed to help people with HIV keep their virus levels under control over time. It may be especially relevant if your current HIV treatment has been hard to stick with or you haven’t had recent viral load checks.
Ciudad Juárez, ChihuahuaAges 18 years+ - NCT05219955Recruiting
Study of caregiver stress and sleep in older adults
This study looks at how caregiver stress affects sleep problems—especially trouble getting going in the morning. If you are a caregiver for someone with dementia and have specific morning sleep/energy difficulties, you may be able to join and help researchers better understand what helps.
Pittsburgh, PennsylvaniaAges 55 years+ - NCT04507555Recruiting
Pharmacist-guided genetic testing to choose antidepressants
This study tests whether doing genetic testing before starting or adjusting antidepressants—guided by a pharmacist—can improve treatment for people with moderate to severe depression. The goal is to help match you with antidepressants more safely and effectively.
Münchenbuchsee, Canton of BernAges 18 years+ - NCT05515159Enrolling by invitation
Blood tests during electroconvulsive therapy
This study looks at blood markers (substances in blood) measured during electroconvulsive therapy, to understand how the treatment is working in the body. If you’re already being considered for ECT, you may be asked for blood samples as part of this research.
BergenAges 18 years+ - NCT04099056Recruiting
Brain scanning and stimulation to study decision-making
This trial uses brain scans and noninvasive brain stimulation to study how people make decisions. It may help researchers understand brain signals involved in choices and potentially improve future treatments.
Atlanta, GeorgiaAges 18–50 - NCT02010866Recruiting
OHSU healthcare staff support for stressed members
This trial is for people who work at Oregon Health & Science University (OHSU) as a medical resident, fellow, or full-time faculty member. It tests an approach to help support staff who feel stressed or distressed.
Portland, OregonAges 18 years+ - NCT07667738RecruitingPhase 2
Parent support program in Peru for parents of young children
This study tests a therapy program called CETA for parents in a specific area of Lima, Peru. It aims to help parents improve their mental health, which may also benefit their children ages 4 to 6.
LimaAges 18 years+ - NCT06210100Recruiting
Brain stimulation for self-harm in teens with depression
This study tests a type of brain stimulation (called aiTBS) that uses magnetic pulses to help reduce self-harm and suicidal thoughts in teens with depression. It's for teens who are in the hospital and have been hurting themselves on purpose.
Dali, YunnanAges 12–18
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,509 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.