Clinical trials
Disability or Chronic Disease Leading to Disablement clinical trials
Below are recruiting disability or chronic disease leading to disablement clinical trials, each written for real people, not researchers. We’re tracking 686 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05400798Enrolling by invitation
Study of injected regenerative cells for rotator cuff tears safety
This study checks the long-term safety of an injection made from your own fat cells for people with a chronic rotator cuff tear. It is mainly focused on monitoring side effects and outcomes over time.
Phoenix, ArizonaAges 30–75 - NCT05374681Recruiting
Test a minimally invasive add-on treatment for brain vessel swelling
This trial studies whether an add-on, minimally invasive procedure works better than standard care for a specific brain blood-vessel problem (CSH) that is larger than 10 mm. It may help reduce symptoms or prevent worsening, if you meet the size and location requirements.
Amiens, FranceAges 18 years+ - NCT05336201RecruitingPhase 2
Brain training program for teens with sickle cell disease
This Phase 2 study tests a cognitive (thinking) training program to help teens with sickle cell disease prepare for the changes in their care as they grow older. It may help with skills like learning, attention, and planning for transition to adult care.
Birmingham, AlabamaAges 10–18 - NCT05359653RecruitingPhase 1/Phase 2
Clemastine to study MRI changes in relapsing MS
This early-phase study tests whether clemastine (a drug being studied for “myelin repair”) changes how MS looks on special MRI scans. It may help researchers understand if the treatment supports restoring nerve covering in people with relapsing-remitting MS.
San Francisco, CaliforniaAges 18–55 - NCT05359991Recruiting
Exercise study in children and teens with lung or blood conditions
This study tests how safe and effective a structured exercise program is for children and teens. It also compares results between children with sickle cell disease, cystic fibrosis, and healthy peers (and some teens after COVID-19 infection).
Irvine, CaliforniaAges 10–17 - NCT05339048Enrolling by invitation
Study of adults from Colombia’s Caribbean coast
This study follows adults who were born or are from Colombia’s Caribbean coast. The goal is to learn about health patterns in this community, but you would not be able to join if you meet certain medical or disability-related criteria.
Cartagena, Departamento de BolívarAges 18–80 - NCT05292794Recruiting
CereGate therapy for freezing of gait in Parkinson’s
This trial tests whether CereGate therapy can reduce “freezing of gait,” a walking problem, in people with Parkinson’s disease who already have deep brain stimulation (DBS). If you meet the device and medication stability requirements, the study may help your walking and movement symptoms measured during testing.
Redwood City, CaliforniaAges 21–80 - NCT05101746Enrolling by invitationPhase 2/Phase 3
Nitric oxide to protect brain and kidneys in babies during heart surgery
This trial studies whether giving nitric oxide during heart-lung bypass surgery can help protect a baby’s brain and kidneys. If you qualify, the study team will check outcomes after surgery to see if benefits happen compared with usual care.
Nashville, TennesseeAges birth–1 year - NCT05052541RecruitingPhase 3
Oral cannabis for long-term spine pain
This trial studies whether taking cannabis by mouth can safely reduce chronic spine pain and improve daily comfort. You may be eligible if you have long-lasting spine pain and can follow study rules about stopping or limiting other cannabis and certain other treatments.
Aurora, ColoradoAges 21–84 - NCT04876339Recruiting
Sound-based training to improve walking after brain illness
This study tests whether using special sounds (sonification) during gait training can improve walking for people with stroke, Parkinson’s disease, or multiple sclerosis. It may help your walking speed, stamina (fatigue), and overall walking pattern.
PaviaAges Up to 80 years - NCT04899037Recruiting
Long-term follow-up for people using an implanted hearing device
This study checks how well long-term care works for people who may use an osseointegrated hearing device (an implanted option that connects to bone). It may help by improving long-term support and outcomes for hearing and day-to-day functioning over about three years.
Tampa, FloridaAges 18–85 - NCT04071847Recruiting
Study tracking results after Abbott deep brain stimulator surgery
This study follows people who are getting a new Abbott deep brain stimulator (DBS) device or replacing the battery/implantable pulse generator to see how outcomes change over time. It mainly applies to certain DBS targets and diagnoses, and it uses follow-up visits to track results.
Tucson, ArizonaAges Any age - NCT04777357RecruitingPhase 3
Cariprazine for bipolar depression in ages 10 to 17
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
Bentonville, ArkansasAges 10–17 - NCT04755699RecruitingEarly Phase 1
Electrical stimulation study for hand or limb movement recovery
This early-stage study tests whether regular, skin-based electrical stimulation can help people with paralysis or weakness regain movement. You would attend frequent clinic sessions for months, while the team checks your ability to follow instructions and your safety.
Manhasset, New YorkAges 18–75 - NCT04730700Recruiting
Radiofrequency treatment test for facet back pain
This study compares a nerve procedure (radiofrequency “neurotomy” using an expandable electrode) to non-procedure medical care for long-lasting low back pain from facet joints. It aims to see whether the procedure helps more safely than conservative treatment.
Kansas City, KansasAges 18 years+ - NCT04732052Recruiting
tDCS treatment for adults with developmental disabilities and aggression
This trial tests whether a non-painful brain stimulation treatment (tDCS) can reduce aggressive behaviors in adults with developmental disabilities. It’s meant for people who have had aggression in the last month and can safely receive the stimulation.
Kingston, OntarioAges 18–65 - NCT04761120Recruiting
Follow-up study for specific heart valve repair ring implants
This study follows people who are going to get certain types of heart valve repair rings or bands. It aims to track safety and outcomes after the Abbott device is implanted in routine care over follow-up visits.
Durham, North CarolinaAges 18 years+ - NCT04673565Enrolling by invitation
Coaching new hearing-aid users to use them more
This study tests whether motivational interviewing (a supportive coaching conversation) can help people who are new to hearing aids wear and use them more successfully. It uses online questionnaires to understand hearing-aid use and comfort.
Vancouver, British ColumbiaAges 18 years+ - NCT03852381Recruiting
Spinal cord stimulation for nerve pain after back surgery
This study looks at how spinal cord stimulation (a device that sends mild signals to the spinal cord) affects nerve pain after lumbar surgery. It also aims to help predict who is most likely to improve and why, comparing patients with and without certain sensory symptoms.
Toronto, OntarioAges 18–80 - NCT04256317RecruitingPhase 2/Phase 3
Azacitidine pills with or without venetoclax for certain blood cancers
This study tests whether a pill form of azacitidine (ASTX030) helps people with myelodysplastic syndromes (MDS), CMML, or AML. Some groups may also receive venetoclax; the goal is better blood cancer control for people who aren’t good candidates for intensive chemotherapy.
Los Angeles, CaliforniaAges 18 years+ - NCT04261478Recruiting
Treatment for stroke caused by blocked brain and neck arteries
This trial studies a procedure that opens blocked blood vessels in and behind the brain during a stroke, sometimes after standard clot-thinning medicine. It may help people who have brain tissue that can still be saved and a major blockage in both the neck and brain arteries.
Montreal, QuebecAges 18 years+ - NCT03918421Recruiting
IgM-MAG neuropathy study using immunoglobulin M treatment
This study looks at a treatment made from immune proteins (immunoglobulin M) to treat neuropathy caused by anti-MAG antibodies. It may help improve nerve symptoms in people with this specific type of nerve condition.
BronAges 18 years+ - NCT04246437RecruitingPhase 1
Brain imaging study for autonomic failure with possible Parkinson disease
This Phase 1 study uses a special injected imaging tracer and an MRI scan to look at brain function in people with autonomic failure. It may help researchers understand what’s happening in conditions that can be related to Parkinson disease, multiple system atrophy, or dementia with Lewy bodies.
Nashville, TennesseeAges 18 years+ - NCT04212780Recruiting
Testing a smarter DBS system for severe essential tremor
This trial tests an upgraded deep brain stimulation (DBS) system that can “sense” tremor and adjust treatment in a loop. It’s designed for people with severe essential tremor whose tremor is still disabling despite standard DBS and medication.
Gainesville, FloridaAges 21–99
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Common questions
- Are there clinical trials for disability or chronic disease leading to disablement?
- Yes. Clin2 currently lists 686 recruiting disability or chronic disease leading to disablement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a disability or chronic disease leading to disablement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a disability or chronic disease leading to disablement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.