Clinical trials
Disease clinical trials
Below are recruiting disease clinical trials, each written for real people, not researchers. We’re tracking 9,374 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04715984Recruiting
Testing brain-circuit targets during DBS surgery in Parkinson’s
This study looks at how brain connections involved in movement may relate to thinking and memory problems in Parkinson’s disease. It happens during a deep brain stimulation (DBS) operation, using tests while the surgeon is placing an electrode.
Nashville, TennesseeAges 40 years+ - NCT04731857Recruiting
Genetic testing results study for rare diseases
This study looks at how well different genetic tests (whole exome/genome sequencing and standard genetic tests) work for diagnosing rare genetic diseases and inherited cancer conditions. It may help confirm which testing approach provides the clearest results for families.
TübingenAges Any age - NCT04706910RecruitingPhase 3
PET scan study to optimize imaging in several diseases
This trial improves a special PET scan (a type of brain/body imaging) using 18F-DOPA, to better show how certain conditions behave in the body. If you or your child may have one of the listed conditions, the study may help your doctors get clearer scan results.
Edmonton, AlbertaAges Any age - NCT04753970RecruitingPhase 1/Phase 2
Study uses retina changes to assess blood vessel health
This study looks at the back of your eyes (the retina) to see if it reflects blood vessel health in the brain. It may help doctors find easier ways to track conditions related to small blood vessel disease.
Jacksonville, FloridaAges 18 years+ - NCT04734626Enrolling by invitation
Leg MRI study for mitochondrial muscle weakness
This study uses an MRI scan of the lower leg to look for signs of muscle problems in people with suspected or confirmed mitochondrial disease, and compares them with healthy volunteers. Participants will lie still in the MRI and do a short, mild exercise during the scan to help the researchers see how muscles work.
Philadelphia, PennsylvaniaAges 7–75 - NCT04731246Recruiting
Eye-movement testing in people with early Parkinson’s
This study uses video recordings of your eye movements to learn more about Parkinson’s disease. It may help researchers better tell Parkinson’s apart from other movement conditions and understand how the disease affects the brain early on.
MonacoAges 18 years+ - NCT04698291Recruiting
Study how genetic differences affect calming immune signals
This study looks at how genetic changes may affect special “calming” immune molecules that help the body resolve inflammation. You may be invited if you already joined the Genes & Health project and had your genome analyzed, and you meet safety and health criteria.
LondonAges 18 years+ - NCT04720365Recruiting
Home video game rehab to help Parkinson’s walking and balance
This trial tests whether a serious (therapeutic) home video-game program can improve walking and balance problems for people with Parkinson’s disease who still have trouble even with levodopa. It also looks at whether the approach is worth it in real-world care (cost and benefits).
BordeauxAges 18 years+ - NCT04744116RecruitingEarly Phase 1
Cord blood cell therapy added to ruxolitinib for steroid-resistant GVHD
This trial studies whether adding cord-blood–derived cells to ruxolitinib can improve steroid-resistant acute graft-versus-host disease (GVHD) affecting the lower gut or liver. It’s meant for people who are not getting better (or are worsening) despite adequate steroid treatment.
Houston, TexasAges 12–80 - NCT04698421Recruiting
Blood and tissue sample collection for rare autoimmune nerve diseases
This study collects biological samples (like blood or other specimens) from people with rare neurological conditions that may involve the immune system. Your samples may help researchers better understand these diseases.
ToulouseAges 6–99 - NCT04715568RecruitingPhase 4
Testing how smoke exposure affects heart health
This study looks at whether being exposed to secondhand tobacco smoke at work affects heart and blood vessel health. It may help researchers understand which people are at higher risk and how the body responds to that exposure.
San Francisco, CaliforniaAges 40 years+ - NCT04707781Recruiting
Database study for people at risk of lung scarring
This trial is a study database that collects information from adults who have other illnesses that can increase the risk of developing interstitial lung disease (lung scarring). It may help researchers better understand who is at risk and how outcomes change over time.
GrazAges 18 years+ - NCT04710576RecruitingPhase 2
Axatilimab for chronic graft-versus-host disease
This trial tests a new drug called axatilimab to help patients whose chronic graft-versus-host disease (a condition where transplanted immune cells attack the body) isn't responding well to standard treatments. Researchers want to find the right dose and see if it can improve symptoms and quality of life.
Birmingham, AlabamaAges 2 years+ - NCT04628585Enrolling by invitation
Follow-up for people with sickle cell treated with gene therapy
This study is a long-term follow-up for people who already received gene therapy for sickle cell disease in a specific sponsor’s clinical trial. It helps researchers watch for long-term safety and outcomes over time.
Birmingham, AlabamaAges 2–53 - NCT04607369Enrolling by invitation
Test using an app to map eye vision blind spots
This trial tests how well an EyeCTester smartphone app can measure vision blind spots and distorted vision compared with standard eye tests. If you qualify, you’ll do short near-vision and “Amsler grid” style tasks in the clinic to help confirm the app is accurate.
Bellaire, TexasAges 18 years+ - NCT04657822RecruitingPhase 4
Crizanlizumab rollover study for people with sickle cell disease
This study lets people with sickle cell disease who already finished a Novartis crizanlizumab trial continue treatment under a rollover plan. It’s designed for participants who benefited from crizanlizumab and completed the earlier study schedule without major ongoing side effects.
Birmingham, AlabamaAges 6 months–100 years - NCT04634916Recruiting
Check how a dialysis fistula device performs in real life
This study monitors how well the BD WavelinQ endoAVF device works after routine clinical use. It may help people who need a dialysis access fistula by sharing real-world safety and performance data.
La Jolla, CaliforniaAges 18 years+ - NCT04604418Recruiting
Tracking outcomes during non-heart procedures in children with heart defects
This study looks at how children with congenital heart disease do during routine non-heart procedures, including medical or minor treatments that are not heart-related. It also measures how much health care they use afterward, which may help improve care planning for families.
Los Angeles, CaliforniaAges Up to 21 years - NCT04639336Recruiting
Pompe disease study of brain and nerve effects
This study looks at how Pompe disease affects the brain and nervous system. You may be able to join if you have a confirmed diagnosis of infantile or late-onset Pompe disease and agree to participate.
Durham, North CarolinaAges birth–18 years - NCT04674449Recruiting
Tests a targeted plan for people with chest pain from heart artery disease
This study aims to match people with angina (chest pain from heart artery problems) to the most helpful treatment plan based on their test results. It’s done around the time doctors are planning an invasive heart scan to look at the coronary arteries.
CorkAges 18 years+ - NCT04661280RecruitingPhase 3
Donepezil compared with non-drug care for Alzheimer’s
This trial compares donepezil (a medicine for Alzheimer’s symptoms) against a non-drug treatment plan. It aims to see which approach helps people with Alzheimer’s who still have measurable thinking ability and specific Alzheimer’s test results.
ParisAges 50 years+ - NCT04654000Recruiting
Rheopheresis to treat painful skin damage in calciphylaxis
This trial studies whether a treatment called rheopheresis, added to standard care, can help people with calciphylaxis whose skin wounds are getting worse. It may be considered when ulcers or dead (necrotic) skin appear despite conventional treatment.
AngersAges 18 years+ - NCT04650932Recruiting
Study tests new stimulation settings for advanced Parkinson’s
This study looks at whether changing how deep brain stimulation (DBS) pulses are delivered can improve symptoms in people with advanced Parkinson’s disease. You may be eligible if you already have a specific Boston Scientific DBS device and have had it implanted for at least 3 months.
Sacramento, CaliforniaAges 18 years+ - NCT04629547RecruitingPhase 2
Sleep study to help prevent Alzheimer’s disease
This trial tests whether treating sleep issues and measuring sleep can help lower the risk of Alzheimer’s disease before it starts. It focuses on older adults with no dementia signs yet.
St Louis, MissouriAges 65 years+
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Common questions
- Are there clinical trials for disease?
- Yes. Clin2 currently lists 9,374 recruiting disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.