Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,057 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07433257Recruiting
Steroid injection for carpal tunnel with diabetes
This study tests if a steroid injection in the wrist helps people with carpal tunnel syndrome, comparing results between those with and without type 2 diabetes. If you have mild to moderate carpal tunnel and either well-controlled diabetes or no diabetes, you may be able to join.
Istanbul, IstanbulAges 18–75 - NCT07426016Recruiting
Comparing two ways to give surfactant to premature babies
This study compares two methods—video laryngoscopy and direct laryngoscopy—to give surfactant (a medicine that helps babies' lungs work better) to very premature infants. It aims to find which method is safer and easier for babies born at 28 weeks or earlier who need surfactant within the first 36 hours after birth.
Dallas, TexasAges birth–3 days - NCT07428863Recruiting
Jump rope for foot health in Down syndrome
This study tests if jumping rope can help improve foot arch alignment in children with Down syndrome who have flat feet. It may offer a simple, fun way to strengthen feet and reduce foot problems.
Lahore, Punjab ProvinceAges 4–15 - NCT07434037Recruiting
Trust and the brain in Down syndrome and Fragile X
This study explores how people with Down syndrome or Fragile X syndrome learn to trust others. It uses simple tasks and a brain scan (MRI) to compare their responses with those of typically developing children and young adults.
BronAges 3–29 - NCT07421011RecruitingPhase 1
Comparing two forms of a drug for healthy volunteers
This study tests two different versions of a drug called Trimedat to see if they work the same way in the body. It is for healthy volunteers to understand how the drug is absorbed and if it is safe.
Saint PetersburgAges 18–45 - NCT07424222RecruitingPhase 1
Ruxolitinib for a serious immune reaction after CAR T therapy
This trial tests a drug called ruxolitinib for a rare but serious condition called IEC-HS that can happen after CAR T cell treatment. The goal is to see if ruxolitinib can calm this overactive immune response.
Baltimore, MarylandAges 18–99 - NCT07417137Recruiting
Long-term study of Angelman syndrome
This study follows people with Angelman syndrome over time to learn more about the condition. It does not test any new treatments, but you need a parent or caregiver to come with you to all visits.
Lexington, MassachusettsAges 1 year+ - NCT07421427Recruiting
Preventing pain after mastectomy with added medication
This trial tests if adding amantadine or duloxetine to the standard drug pregabalin can better prevent chronic pain after a mastectomy. It may help you if you're undergoing a modified radical mastectomy for breast cancer.
CairoAges 18–65 - NCT06196203RecruitingPhase 2
Study of AK117 with Azacitidine for High-Risk MDS
This trial tests a new drug, AK117, combined with azacitidine for people newly diagnosed with high-risk myelodysplastic syndromes (MDS), a blood disorder. The goal is to see if the combination can help improve outcomes.
Los Angeles, CaliforniaAges 18 years+ - NCT06636513Recruiting
Testing SMT04 for irritable bowel syndrome
This trial tests a new treatment called SMT04 for people with irritable bowel syndrome (IBS), specifically the diarrhea or mixed types. It may help reduce symptoms like abdominal pain and changes in bowel habits.
Singapore, SingaporeAges 21–55 - NCT07413224Enrolling by invitation
Effects of AEF0217 in People with Down Syndrome
This study looks at the effects of a medication called AEF0217 in people with Down syndrome. It is for participants who have already completed an earlier study of AEF0217 and their caregivers.
BarcelonaAges Any age - NCT07413978RecruitingPhase 1/Phase 2
Stem cell injection for severe ARDS
This trial tests whether an injection of stem cells from umbilical cords can help people with severe ARDS (a type of lung failure) recover faster. It is for those who have not improved after standard treatment and whose ARDS is caused by an infection (not COVID-19).
Wuhan, HubeiAges 18–80 - NCT07415967Recruiting
Dual-task exercise for rotator cuff shoulder pain
This study tests an exercise program that combines shoulder movements with mental tasks (like counting or naming things) to improve pain and function. It is for people with ongoing shoulder pain from common rotator cuff problems.
IstanbulAges 18–65 - NCT07414069Recruiting
Laser therapy for carpal tunnel syndrome
This trial tests high-intensity laser therapy as a treatment for mild to moderate carpal tunnel syndrome. It aims to see if the laser can improve symptoms and hand function without surgery or injections.
Ankara, Ankara, ÇankayaAges 18–65 - NCT07411222Recruiting
Emotional Eating, Sleep, and Metabolic Health Study
This study examines how emotional eating, sleep quality, and mental state relate to metabolic syndrome (a group of conditions like high blood pressure, high blood sugar, and extra belly fat) in people with stable schizophrenia or bipolar disorder. It aims to help understand and improve overall health.
Bolu, BoluAges 18–65 - NCT07406932Recruiting
JAK inhibitors vs standard therapy for lung scarring in Anti-Synthetase Syndrome
This trial tests whether a new class of drugs called JAK inhibitors (which block inflammation signals) is better than a standard treatment (calcineurin inhibitors) for people with lung scarring (interstitial lung disease) caused by Anti-Synthetase Syndrome. It is for people who have not yet taken any immune-suppressing medications for this condition.
Beijing, Beijing MunicipalityAges 18–75 - NCT07400783Recruiting
Study of short bowel syndrome in children
This study looks at short bowel syndrome in children who have had intestinal surgery. It may help doctors understand how to better treat this condition.
Florence, FlorenceAges 4 months–17 years - NCT07403812Recruiting
Checking thinking skills after CAR-T therapy
This study uses a simple iPad test to check for thinking problems that can happen after CAR-T cell therapy. It aims to catch these issues early so they can be managed better.
Boston, MassachusettsAges 18 years+ - NCT07400848Recruiting
Symptoms and recovery after COVID-19 vaccine
This study looks at people who developed new, long-lasting symptoms after a COVID-19 vaccine. It aims to understand their symptoms, do lab tests, and see how they recover over time.
BernAges 18 years+ - NCT07401888Recruiting
Milk Study for Metabolic Syndrome
This study looks at how drinking milk affects adults with metabolic syndrome — a set of conditions like high blood pressure and high blood sugar. It may help if you are at risk for heart disease or diabetes and want to see if adding milk can improve your health.
Rochester, MinnesotaAges 18–70 - NCT07396246RecruitingPhase 2
Comparing two treatments for hip pain
This trial tests if a new artery-blocking procedure works better than platelet-rich plasma shots for people with chronic hip pain (greater trochanteric pain syndrome) who haven't improved with physical therapy or anti-inflammatory drugs.
GuimarãesAges 18–80 - NCT07395076Recruiting
Study of immune causes of acute respiratory distress
This trial looks at how the immune system might cause severe breathing problems (ARDS). It may help doctors understand what happens in the lungs during this condition and find better ways to treat it.
ParisAges 18 years+ - NCT07390071Recruiting
Remote rehab program for CAR-T cell therapy patients
This trial tests a home-based rehabilitation program using phone or video sessions to help people with lymphoma or myeloma recover better after CAR-T cell therapy. It aims to improve physical function and quality of life during treatment.
Salt Lake City, UtahAges 21 years+ - NCT07389603Recruiting
Time-restricted eating and nutrition counseling for metabolic syndrome
This study tests if eating only within a shorter daily window, combined with personalized nutrition advice, can improve metabolic syndrome—a cluster of conditions like high blood sugar, high blood pressure, and excess belly fat. You may qualify if you're an adult who eats over 14 hours a day and has at least three of the listed health markers.
Ciudad Guzmán, JaliscoAges 18–60
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,057 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.